• 1
    Horvitz HR, Shaham S, Hengartner MO. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp Quant Biol 1994; 59: 37785
  • 2
    Barr AB, Moore DJ, Paulsen CA. Germinal cell loss during human spermatogenesis. J Reprod Fertil 1971; 25: 7580
  • 3
    Huckins C. The morphology and kinetics of spermatogonial degeneration in normal adults rats: an analysis using a simplified classification of the germinal epithelium. Anat Rec 1978; 190: 90527
  • 4
    Kerr JB. Spontaneous degeneration of germ cells in normal rat testis: assessment of cell types and frequency during the spermatogenic cycle. J Reprod Fertil 1992; 95: 82530
  • 5
    Tapanainen J, Tilly JL, Hsueh AJW et al. Hormonal control of apoptotic cell death in the testes: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 1993; 7: 64350
  • 6
    Billing H, Furuta I, Hsueh AJW et al. Apoptosis in testis germ cells. Developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 1995; 136: 512
  • 7
    Troiano L, Fustini MF, Franceschi C et al. Apoptosis and spermatogenesis: Evidence from an in vivo model of testosterone withdrawal in the adult rat. Biochem Bioph Res Commun 1994; 202: 131521
  • 8
    Tujimoto Y, Croce C. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 1986; 83: 52148
  • 9
    Hockenbery DM, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (Lond) 1990; 348: 3346
  • 10
    Hockenbery DM, Zutter M, Hickey W et al. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acd Sci USA 1991; 88: 69615
  • 11
    Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. BCL-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991; 67: 87988
  • 12
    Oltvai Z, Milliman C, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 60919
  • 13
    Fernandes-Alnemri T, Litwack G, Alnemri ES. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1-converting enzyme. J Biol Chem 1994; 269: 307614
  • 14
    Krajewski S, Krajewski M, Reed JC. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 1994; 145: 132333
  • 15
    Alnemri ES, Livingston DJ, Yuan J et al. Human ICE/CED-3 protease nomenclature. Cell 1996; 87: 171
  • 16
    Fujisawa M, Hiramine T, Kamidono S. Decrease of apoptosis of germ cells in the testes of infertile men with varicocele. World J Urol 1999; 17: 296300
  • 17
    World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm–Cervical Mucus Interaction, 3rd edn. Cambridge: Cambridge University Press, 1992
  • 18
    Krajewski S, Krajewski M, Reed JC. Immunohistochemical analysis of in vivo patterns of Bak expression, a pro-apoptotic member of the Bcl-2 protein family. Cancer Res 1996; 56: 284955
  • 19
    Krajewski S, Zapata JM, Reed JC. Detection of multiple antigens on Western blots. Anal Biochem 1996; 236: 2218DOI: 10.1006/abio.1996.0160
  • 20
    Krajewski M, Wang H-G, Reed JC et al. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res 1997; 57: 160513
  • 21
    Datta R, Banach D, Kufe DW et al. Activation of the CPP32 protease in apoptosis induced by 1-beta-d-arabinofuranosylcytosine and other DNA-damaging agents. Blood 1996; 88: 193643
  • 22
    Schlegel J, Peters I, Nicholson DW et al. CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem 1996; 271: 18414
  • 23
    Datta R, Kojima H, Kufe DW et al. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. J Biol Chem 1997; 272: 19659
  • 24
    Armstrong R, Aja T, Tomaselli K et al. Fas-induced activation of the cell death related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J Biol Chem 1996; 271: 168505
  • 25
    Lin WW, Lamb DJ, Lipshultz LI, Kim ED. The role of autosomal cell apoptosis regulator genes in human spermatogenesis. Int Urol Nephrol 1999; 31: 23746
  • 26
    Nagata S, Golstein P. The Fas death factor. Science 1995; 267: 144956
  • 27
    Jeongwu L, John HR, Kim B et al. The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 1997; 138: 20818
  • 28
    Steinberger E. Hormonal control of mammalian spermatogenesis. Physiol Rev 1991; 51: 122
  • 29
    Awoniyi CA, Santulli R, Zirkin BR et al. Restoration of advanced spermatogenic cells in the experimentally regressed rat testis: quantitative relationship to testosterone concentration within the testis. Endocrinology 1989; 124: 121723
  • 30
    Cummingham GR, Huckins C. Persistence of complete spermatogenesis in the presence of low intratesticular concentrations of testosterone. Endocrinology 1979; 105: 17786