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References

  • 1
    Santos DR. Chá de Quebre-Pedra (Phyllanthus niruri) na litíase urinária em humanos e ratos. PhD Thesis. Escola Paulista de Medicina, Sa˜o Paulo, 1990
  • 2
    Worcester EM. Inhibitors of stone formation. Sem Nephrol 1996; 16: 47486
  • 3
    Coelho STNS. Litíase experimental sistematizaça˜o do modelo em corpo estranho estudado em ratos. MS Thesis. Escola Paulista de Medicina, Sa˜o Paulo, 1989
  • 4
    Meyer JL, Smith LH. Growth of calcium oxalate crystals. I. A model for urinary stone growth. Invest Urol 1977; 13: 315
  • 5
    Pfeffer JM, Pfeffer MA, Frohlich ED. Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats. J Lab Clin Med 1971; 78: 95762
  • 6
    Michelacci YM, Glashan RQ, Schor N. Urinary excretion of glycosaminoglycans in normal and stone forming subjects. Kidney Int 1989; 36: 10228
  • 7
    Michelacci YM, Boim MA, Bergamaschi CT, Rovigatti RM, Schor N. Possible role for chondroitin sulfate in urolithiasis: in vivo studies in an experimental model. Clin Chim Acta 1992; 208: 18
  • 8
    Unander DW, Webster GL, Blumberg BS. Usage and bioassays in Phyllanthus (Euphorbiaceae). III. The subgenera Eriocos, Conami, Gomphidium, Botryanthus, Xylphylla and Phylanthodendrum, and a complete list of the species cited in the three part series. J Ethnopharmacol 1992; 36: 10312
  • 9
    Hnatyszyn O, Mino J, Gorzalczany S, Opezzo J, Coussio J, Acevedo C. Diuretic activity of an aqueous extract of Phyllanthus sellowianus. Phytomed 1999; 6: 1779
  • 10
    Laranja SMR, Bergamaschi CMT, Schor N. Evaluation of acute administration of natural products with potential diuretic effects, in humans. Mem Inst Oswaldo Cruz 1991; 38: 136
  • 11
    Calixto JB, Yunes RA, Neto AS, Valle RM, Rae GA. Antispasmodic effects of an alkaloid extracted from Phyllanthus sellowianus: a comparative study with papaverine. Braz J Med Biol Res 1984; 17: 31321
  • 12
    Paulino NM, Cechinel-Filho V, Yunes RA, Calixto JB. The relaxant effect of extract of Phyllanthus urinaria in the guinea-pig isolated trachea. Evidence for involvement of ATP-sensitive potassium channels. J Pharm Phamacol 1996; 48: 115863
  • 13
    Paulino N, Pizollattiu MG, Yunes RA, Filho VC, Creczynski-Pasa TB, Calixto JB. The mechanisms underlying the relaxant effect of methyl and ethyl gallates in the guinea-pig trachea in vitro: contribution of potassium channels. Naunyn Schmiedebergs Arch Pharmacol 1999; 360: 3316
  • 14
    Santos AR, Filho VC, Yunes RA, Calixto JB. Analyses of the mechanisms underlying the antinociceptive effect of the extracts of the plants from the genus Phyllanthus. Gen Pharmacol 1995; 26: 1499506
  • 15
    Santos AR, Filho VC, Niero R et al. Analgesic effects of callus culture extracts from selected species of Phyllanthus in mice. J Pharm Pharmacol 1994; 46: 7559
  • 16
    Hurst RE, Zebrowski R. Identification of proteoglycans present at high density on bovine and human bladder luminal surface. J Urol 1994; 152: 16415
  • 17
    Akcay T, Konukoglu D. Glycosaminoglycans excretion in interstitial cystitis. Int J Nephrol 1999; 31: 4315
  • 18
    Ryall RL. Glycosaminoglycans, proteins, and stone formation: adult themes and child's play. Pediatr Nephrol 1996; 10: 65666
  • 19
    Shum DKY, Gohel MDI. Separate effects of urinary chondroitin sulfate and heparan sulfate upon the crystallization of urinary calcium oxalate – differences between stone formers and natural controls. Clin Sci 1993; 85: 339
  • 20
    Suzuki K, Ryall RL. The effect of heparan sulphate on the crystallization of calcium oxalate in diluted, ultrafiltered human urine. Br J Urol 1996; 78: 1521
  • 21
    Osswald H, Weinheimer G, Schutt D et al. Effective prevention of calcium oxalate crystal formation in vitro and in vivo by pentosan polysulfate. In WalkerVR, SuttonRAL, CameronECB, PakCYC, RobertsonWG eds, Urolithiasis. New York: Plenum Press, 1989: 1414
  • 22
    Ryall RL, Hamett RM, Habbert CM, Edyne KA, Marshall VR. Effects on chondroitin sulfate, human serum albumin and Tamm-Horsfall, mucoprotein on calcium oxalate crystallization in undiluted human urine. Urol Res 1991; 19: 1818
  • 23
    Campos AH, Schor N. Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis. Nephron 1999; 895: 3937
  • 24
    Khan SR. Interactions between stone-forming calcific crystals and macromolecules. Urol Int 1997; 59: 5971

Authors

  1. Authors

A.M. Freitas, MS, PhD student.

N. Schor, MD, PhD, Full Professor.

M.A. Boim, PhD, Associate Researcher.

Abbreviations
Pn

Phyllanthus niruri

CaOx

calcium oxalate

GAGs

glycosaminoglycans

MAP

mean arterial tail pressure.