Sexual factors and prostate cancer
Article first published online: 23 JUL 2003
Volume 92, Issue 3, pages 211–216, August 2003
How to Cite
Giles, G.G., Severi, G., English, D.R., McCredie, M.R.E., Borland, R., Boyle, P. and Hopper, J.L. (2003), Sexual factors and prostate cancer. BJU International, 92: 211–216. doi: 10.1046/j.1464-410X.2003.04319.x
- Issue published online: 23 JUL 2003
- Article first published online: 23 JUL 2003
- Accepted for publication 12 April 2003
- prostate cancer;
- sexual factors;
- case-control study
To assess whether prostate cancer might be related to hormone levels and, by inference, to differences in sexual activity.
PATIENTS, SUBJECTS AND METHODS
In a case-control study of men with prostate cancer aged < 70 years at diagnosis and age-matched control subjects, information was collected on two aspects of sexual activity; the number of sexual partners and the frequency of total ejaculations during the third to fifth decades of life.
There was no association of prostate cancer with the number of sexual partners or with the maximum number of ejaculations in 24 h. There was a negative trend (P < 0.01) for the association between risk and number of ejaculations in the third decade, independent of those in the fourth or fifth. Men who averaged five or more ejaculations weekly in their 20s had an odds ratio (95% confidence interval) of 0.66 (0.49–0.87) compared with those who ejaculated less often.
The null association with the number of sexual partners argues against infection as a cause of prostate cancer in this population. Ejaculatory frequency, especially in early adult life, is negatively associated with the risk of prostate cancer, and thus the molecular biological consequences of suppressed or diminished ejaculation are worthy of further research.