Effect of renal transplantation on sperm quality and sex hormone levels
Article first published online: 23 JUL 2003
Volume 92, Issue 3, pages 281–283, August 2003
How to Cite
Akbari, F., Alavi, M., Esteghamati, A., Mehrsai, A., Djaladat, H., Zohrevand, R. and Pourmand, G. (2003), Effect of renal transplantation on sperm quality and sex hormone levels. BJU International, 92: 281–283. doi: 10.1046/j.1464-410X.2003.04323.x
- Issue published online: 23 JUL 2003
- Article first published online: 23 JUL 2003
- Accepted for publication 25 April 2003
- renal transplantation;
- follicle-stimulating hormone;
- luteinizing hormone;
To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.
PATIENTS AND METHODS
Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5-point scale. The paired t-test was used to assess the statistically significance of differences in all analyses.
Sperm motility improved significantly (P < 0.001) but there were no significant changes in morphology or density (P = 0.33 and 0.068, respectively). Testosterone levels increased and FSH, LH and prolactin decreased significantly (P < 0.05) after renal transplantation. The IIEF showed that of the 30 patients, 14 were impotent before surgery and only six remained so afterward (P < 0.05).
Although sperm morphology and density did not improve after renal transplantation, there were highly significant changes in sperm motility. Hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal; sexual function was also significantly better. Further studies are needed to confirm these results.