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Effect of renal transplantation on sperm quality and sex hormone levels

  1. F. Akbari1,
  2. M. Alavi2,
  3. A. Esteghamati4,
  4. A. Mehrsai3,
  5. H. Djaladat3,
  6. R. Zohrevand3,
  7. G. Pourmand3

Article first published online: 23 JUL 2003

DOI: 10.1046/j.1464-410X.2003.04323.x

Issue

BJU International

BJU International

Volume 92, Issue 3, pages 281–283, August 2003

Additional Information

How to Cite

Akbari, F., Alavi, M., Esteghamati, A., Mehrsai, A., Djaladat, H., Zohrevand, R. and Pourmand, G. (2003), Effect of renal transplantation on sperm quality and sex hormone levels. BJU International, 92: 281–283. doi: 10.1046/j.1464-410X.2003.04323.x

Author Information

  1. 1

    IVF Unit, Mirzakoochak Khan Hospital,

  2. 2

    Departments of Pathology and

  3. 3

    Urology (Renal Transplant Unit), Sina Hospital, and

  4. 4

    Department of Endocrinology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

*Prof G. Pourmand, Renal Transplant Unit, Sina Hospital, Department of Urology, Tehran University of Medical Science, Tehran, Iran. e-mail: gh_pourmand@hotmail.com

Publication History

  1. Issue published online: 23 JUL 2003
  2. Article first published online: 23 JUL 2003
  3. Accepted for publication 25 April 2003

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Keywords:

  • renal transplantation;
  • follicle-stimulating hormone;
  • luteinizing hormone;
  • prolactin;
  • testosterone;
  • impotence

OBJECTIVE

To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.

PATIENTS AND METHODS

Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5-point scale. The paired t-test was used to assess the statistically significance of differences in all analyses.

RESULTS

Sperm motility improved significantly (P < 0.001) but there were no significant changes in morphology or density (P = 0.33 and 0.068, respectively). Testosterone levels increased and FSH, LH and prolactin decreased significantly (P < 0.05) after renal transplantation. The IIEF showed that of the 30 patients, 14 were impotent before surgery and only six remained so afterward (P < 0.05).

CONCLUSION

Although sperm morphology and density did not improve after renal transplantation, there were highly significant changes in sperm motility. Hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal; sexual function was also significantly better. Further studies are needed to confirm these results.

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