• 1
    Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82: 46
  • 2
    Ingber D, Fujita T, Kishimoto S et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990; 348: 5557
  • 3
    Yanase T, Tamura M, Fujita K, Kodama S, Tanaka K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993; 53: 256670
  • 4
    Yamaoka M, Yamamoto T, Masaki T et al. Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(Chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470). Cancer Res 1993; 53: 42627
  • 5
    Catalona WJUrothelial tumors of urinary tract. In Campbell’s Urology, 6th edn, Vol. 2. Philadelphia: Saunders,1992; 1094158
  • 6
    Malmstrom PU, Brush C, Norlen BJ. Recurrence, progression and survival in bladder cancer: a retrospective analysis of 232 patients with greater than or equal to 5-year follow up. Scand J Urol Nephrol 1987; 21: 18595
  • 7
    Jaeger T, Weidner N, Chew K et al. Tumor angiogenesis correlates with lymph node metastasis in invasive bladder cancer. J Urol 1994; 154: 6971
  • 8
    Dickinson A, Fox S, Persad R, Holler J, Silbley G, Harris A. Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas. Br J Urol 1994; 74: 7626
  • 9
    Druckrey H, Preussmann R, Ivankovic S et al. Selektive Erzeugung von Blasenkrebs an Ratten durch Dibutyl-und N-Butyl-N-butanol(4)-nitrosamin. Z Krebsforsch 1964; 66: 28090
  • 10
    Osono S, Babaya K, Sasaki K et al. Rat urinary bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl) nitrosamine and N-methyl-N-nitrosurea. Urol Res 1990; 18: 3236
  • 11
    Babaya K, Takahashi S, Momose H et al. Effect of single chemotherapeutic agent on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats. Urol Res 1987; 15: 32934
  • 12
    Ohtani M, Fukushima S, Okamura T et al. Effect of intravesical instillation of antitumor chemotherapeutic agent on bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine. Cancer 1984; 54: 15259
  • 13
    Ito N, Hiasa Y, Tamai A et al. Histogenesis of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in rats. GANN 1969; 60: 40110
  • 14
    Oyasu R, Iwasaki T, Matsumoto M, Hirao Y, Tabuchi Y. Induction of tumors in heterotopic bladder by topical application of N-methyl- N-nitrosourea and N-butyl-N-(3-carboxypropyl) nitrosamine. Cancer Res 1978; 38: 301925
  • 15 Japanese Urological Association and The Japanese Society of Pathology. General Rules for Clinical and Pathological Studies on Bladder Cancer, 2nd edn,
  • 16
    Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J. Tumor angiogensis correlates with metastatis in invasive prostate carcinoma. Am J Path 1993; 143: 4019
  • 17
    Kusaka M, Sudo K, Fujita T et al. Potent anti-angiogenic action of AGM-1470: comparison to the fumajillin parent. Biochem 1991; 174: 10706
  • 18
    Yamaoka M, Yamamoto T, Ikeyama S, Sudo K, Fujita T. Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Cancer Res 1993; 53: 52336
  • 19
    Morita T, Shinohara N, Tokue A. Antitumour effect of a synthetic analogue of fumagillin on murine renal carcinoma. Br J Urol 1994; 74: 41621
  • 20
    Fujioka T, Hasegawa M, Ogiu K et al. Antitumor effect of angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470) against murine renal cell carcinoma. J Urol 1996; 155: 17758
  • 21
    Tatematsu M, Cohen SM, Fukushima S et al. Neovascularization in benign and malignant urinary bladder epithelial proliferative lesions of rat observed in situ by scanning electron microscopy and autoradiography. Cancer Res 1978; 38: 1792800
  • 22
    Tanaka Y, Kawamata H, Fujimoto K, Oyasu R. Angiogenesis inhibitor TNP-470 suppresses tumorigenesis in rat urinary bladder. J Urol 1997; 157: 6388
  • 23
    Kusaka M, Sudo K, Matsutani E et al. Cytostatic inhibitor of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br J Cancer 1994; 69: 2126
  • 24
    Hori A, Ikeyama S, Sudo K et al. Suppression of cyclin D1 mRNA expression by the angiogenesis inhibitor TNP-470 (AGM-1470) in vascular endothelial cells. Biochem Biophys Res Commun 1994; 204: 106773
  • 25
    Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267: 109314
  • 26
    O’Brien T, Cranton D, Fuggle S, Bicknell R, Harris AL. Different angiogenic pathways characterize superficial and invasive bladder cancer. Cancer Res 1995; 55: 5103
  • 27
    Ferrara N. Vascular endothelial growth factor. TCM 1993; 3: 24450
  • 28
    Kudelka AP, Levy T, Verschaegen CF et al. A Phase I of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin Cancer Res 1997; 3: 15015