Impact of cigarette smoking on the incidence of Type 2 diabetes mellitus in middle-aged Japanese men: the Osaka Health Survey

  1. S. Uchimoto1,
  2. K. Tsumura1,
  3. T. Hayashi2,
  4. C. Suematsu2,
  5. G. Endo2,
  6. S. Fujii3,
  7. K. Okada4

Article first published online: 24 DEC 2001

DOI: 10.1046/j.1464-5491.1999.00173.x

Issue

Diabetic Medicine

Diabetic Medicine

Volume 16, Issue 11, pages 951–955, November 1999

Additional Information

How to Cite

Uchimoto, S., Tsumura, K., Hayashi, T., Suematsu, C., Endo, G., Fujii, S. and Okada, K. (1999), Impact of cigarette smoking on the incidence of Type 2 diabetes mellitus in middle-aged Japanese men: the Osaka Health Survey. Diabetic Medicine, 16: 951–955. doi: 10.1046/j.1464-5491.1999.00173.x

Author Information

  1. 1

    Second Department of Internal Medicine and

  2. 2

    Department of Preventive Medicine and Environmental Health, Osaka City University Medical School, Osaka City, Japan

  3. 3

    Environment and Public Health Bureau, Osaka City, Japan

  4. 4

    Medical Center for Employee’s Health, Osaka Gas Co., Osaka City, Japan

* Dr Kei Tsumura, Second Department of Internal Medicine, Osaka City University Medical School, 1–4-3, Asahi-machi, Abeno-ku, Osaka 545–8585, Japan. E-mail: tmrk@med.osaka-cu.ac.jp

Publication History

  1. Issue published online: 24 DEC 2001
  2. Article first published online: 24 DEC 2001
  3. Received 15 December 1998; revised 23 April 1999; accepted 30 April 1999

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Keywords:

  • cigarette smoking;
  • middle-aged;
  • new criteria for diabetes mellitus;
  • prospective study;
  • Type 2 diabetes mellitus

Summary

Aims To assess the impact of cigarette smoking on the incidence of Type 2 diabetes mellitus (DM) in middle-aged Japanese men.

Methods The study enrolled 6250 men aged 35–60 years and free of diabetes, impaired fasting glucose and hypertension at entry. Type 2 DM was defined by a fasting plasma glucose level ≥ 7.0 mmol/l or physician-diagnosed Type 2 DM.

Results Four hundred and fifty cases of Type 2 DM were confirmed during the 60 904 person-years follow-up. After adjustment for multiple covariates, including age, body mass index, alcohol consumption, physical activity, parental history of diabetes and the level of fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol and haematocrit, the relative risk of Type 2 DM among current smokers compared with non-smokers was 1.47 (95% confidence interval (CI) 1.14–1.92). Men who smoked > 30 cigarettes/day had a multivariate-relative risk of 1.73 (95% CI 1.20–2.48) compared with non-smokers. The number of cigarettes smoked daily and the pack-year values were positively related to the development of Type 2 DM in a dose-dependent manner (P for trends = 0.0026 and 0.001, respectively).

Conclusions A cigarette smoking habit is an independent risk factor for Type 2 DM.

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