Impact of cigarette smoking on the incidence of Type 2 diabetes mellitus in middle-aged Japanese men: the Osaka Health Survey
Version of Record online: 24 DEC 2001
Volume 16, Issue 11, pages 951–955, November 1999
How to Cite
Uchimoto, S., Tsumura, K., Hayashi, T., Suematsu, C., Endo, G., Fujii, S. and Okada, K. (1999), Impact of cigarette smoking on the incidence of Type 2 diabetes mellitus in middle-aged Japanese men: the Osaka Health Survey. Diabetic Medicine, 16: 951–955. doi: 10.1046/j.1464-5491.1999.00173.x
- Issue online: 24 DEC 2001
- Version of Record online: 24 DEC 2001
- Received 15 December 1998; revised 23 April 1999; accepted 30 April 1999
- cigarette smoking;
- new criteria for diabetes mellitus;
- prospective study;
- Type 2 diabetes mellitus
Aims To assess the impact of cigarette smoking on the incidence of Type 2 diabetes mellitus (DM) in middle-aged Japanese men.
Methods The study enrolled 6250 men aged 35–60 years and free of diabetes, impaired fasting glucose and hypertension at entry. Type 2 DM was defined by a fasting plasma glucose level ≥ 7.0 mmol/l or physician-diagnosed Type 2 DM.
Results Four hundred and fifty cases of Type 2 DM were confirmed during the 60 904 person-years follow-up. After adjustment for multiple covariates, including age, body mass index, alcohol consumption, physical activity, parental history of diabetes and the level of fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol and haematocrit, the relative risk of Type 2 DM among current smokers compared with non-smokers was 1.47 (95% confidence interval (CI) 1.14–1.92). Men who smoked > 30 cigarettes/day had a multivariate-relative risk of 1.73 (95% CI 1.20–2.48) compared with non-smokers. The number of cigarettes smoked daily and the pack-year values were positively related to the development of Type 2 DM in a dose-dependent manner (P for trends = 0.0026 and 0.001, respectively).
Conclusions A cigarette smoking habit is an independent risk factor for Type 2 DM.