Risk of developing diabetes is inversely related to lung function: a population-based cohort study
Article first published online: 7 MAR 2002
Volume 19, Issue 2, pages 167–170, February 2002
How to Cite
Engström, G. and Janzon, L. (2002), Risk of developing diabetes is inversely related to lung function: a population-based cohort study. Diabetic Medicine, 19: 167–170. doi: 10.1046/j.1464-5491.2002.00652.x
- Issue published online: 7 MAR 2002
- Article first published online: 7 MAR 2002
- Accepted 29 August 2001
- diabetes mellitus;
- forced expiratory volume;
- vital capacity
Aim To investigate whether reduced lung function is a risk factor for developing diabetes.
Methods Non-diabetic men (n = 382) from the population-based cohort ‘Men Born in 1914’ were examined with spirometry at age 55 years. The cohort was re-examined at 68 years. Diabetes and fasting plasma glucose at follow-up were studied in relation to vital capacity (VC) and forced expiratory volume (FEV1.0) at baseline.
Results Fifteen men developed diabetes during the follow-up. The percentage with diabetes in the 1st, 2nd, 3rd and top quartile of vital capacity were 7%, 5%, 2%, and 1%, respectively (P for trend = 0.01). Fasting glucose (log transformed, mmol/l) at follow-up was 1.63 ± 0.16, 1.62 ± 0.18, 1.61 ± 0.11 and 1.60 ± 0.11, respectively (P for trend = 0.11). The longitudinal associations between VC and diabetes (P = 0.001) and log glucose (P = 0.036) were significant after adjustments for several potential confounders. FEV1.0 at baseline showed similar associations with diabetes at follow-up.
Conclusions The risk of developing diabetes is inversely associated with pulmonary function among middle-aged men.