Angiotensin-I-converting enzyme insertion/deletion polymorphism and high urinary albumin concentration in French Type 2 diabetes patients

  1. S. Hadjadj1,
  2. Y. Gallois1,2,
  3. F. Alhenc-Gelas1,3,
  4. G. Chatellier1,4,
  5. M. Marre1,3,5,*,
  6. for the DIABHYCAR Study Group1

Article first published online: 21 JUL 2003

DOI: 10.1046/j.1464-5491.2003.01024.x

Issue

Diabetic Medicine

Diabetic Medicine

Volume 20, Issue 8, pages 677–682, August 2003

Additional Information

How to Cite

Hadjadj, S., Gallois, Y., Alhenc-Gelas, F., Chatellier, G., Marre, M. and for the DIABHYCAR Study Group (2003), Angiotensin-I-converting enzyme insertion/deletion polymorphism and high urinary albumin concentration in French Type 2 diabetes patients. Diabetic Medicine, 20: 677–682. doi: 10.1046/j.1464-5491.2003.01024.x

Author Information

  1. 1

    Service de Médecine Interne, Endocrinologie, University Hospital, Poitiers,

  2. 2

    Biochimie, Faculté de Médecine d’Angers, Angers, and

  3. 3

    INSERM U 327,

  4. 4

    Service d’Informatique Médicale, Hôpital Européen Georges Pompidou and

  5. 5

    Service d’Endocrinologie, Diabétologie, Nutrition, Hôpital Bichat, Paris, France

*Correspondence to: Professor M. Marre, Service d’Endocrinologie–Diabetologie-Nutrition, Hôpital BICHAT-46, Rue Henri Huchard, 75877 Paris Cedex 18, France. E-mail: michel.marre@bch.ap-hop-paris.fr

Publication History

  1. Issue published online: 21 JUL 2003
  2. Article first published online: 21 JUL 2003
  3. Accepted 4 March 2003

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Keywords:

  • angiotensin-converting enzyme;
  • diabetic nephropathy;
  • genetics;
  • Type 2 diabetes;
  • urinary albumin excretion rate

Abstract

Aims Family-based studies suggest a genetic basis for nephropathy in Type 2 diabetes. The angiotensin-I-converting enzyme (ACE) gene is a candidate gene for Type 1 diabetes nephropathy. We assessed the association between high urinary albumin concentration and ACE insertion/deletion (I/D) polymorphism, in French Type 2 diabetes patients.

Methods We studied 3139 micro/macroalbuminuric French patients recruited in the DIABHYCAR Study, an ACE inhibition trial in Type 2 diabetes patients with renal and cardiovascular outcomes. The main inclusion criteria were age ≥ 50 years, urinary albumin concentration ≥ 20 mg/l assessed centrally during two consecutive screening visits, and plasma creatinine concentration ≤ 150 µmol/l. These patients were compared with 605 normoalbuminuric (NA; urinary albumin concentration < 10 mg/l at first screening for the DIABHYCAR Study) French patients. ACE I/D genotype was determined by nested polymerase chain reaction.

Results The ACE I/D polymorphism was in Hardy–Weinberg equilibrium. The distribution of genotypes did not differ significantly between micro/macroalbuminuric and NA patients: 552 and 115 II, 1468 and 282 ID, 1119 and 208 DD (P = 0.67). However, the ACE D allele was more frequent among normotensive micro/macroalbuminuric patients than among NA patients (P = 0.039).

Conclusions The ACE I/D polymorphism was not associated with high urinary albumin concentration in French Type 2 diabetes patients.

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