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Brachial-ankle pulse wave velocity measured automatically by oscillometric method is elevated in diabetic patients with incipient nephropathy
Article first published online: 22 OCT 2003
DOI: 10.1046/j.1464-5491.2003.01043.x
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How to Cite
Yokoyama, H., Hirasawa, K., Aoki, T., Ishiyama, M. and Koyama, K. (2003), Brachial-ankle pulse wave velocity measured automatically by oscillometric method is elevated in diabetic patients with incipient nephropathy. Diabetic Medicine, 20: 942–945. doi: 10.1046/j.1464-5491.2003.01043.x
Publication History
- Issue published online: 22 OCT 2003
- Article first published online: 22 OCT 2003
- Accepted 28 April 2003
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Keywords:
- albuminuria;
- atherosclerosis;
- incipient nephropathy;
- pulse wave velocity
Abstract
Aims To examine whether brachial-ankle pulse wave velocity (baPWV), a possible early marker of atherosclerotic vascular damage, is associated with albuminuria in patients with Type 2 diabetes.
Methods BaPWV was measured by automatic oscillometric method in 346 Type 2 diabetic patients with normoalbuminuria (a mean level of three times measurements of albumin-to-creatinine (ACR) < 30 µg/mg creatinine; n = 200), incipient nephropathy (a mean level of ACR ≥ 30 and < 300 µg/mg creatinine; n = 119), and clinical nephropathy (a mean level of ACR ≥ 300 µg/mg creatinine; n = 27), and without peripheral vascular disease.
Results BaPWV (cm/s) was significantly higher in patients with incipient nephropathy (1722 ± 382) and clinical nephropathy (1763 ± 322) than in patients with normoalbuminuria (1559 ± 343, P < 0.0001, respectively). By univariate analysis it correlated significantly with age (r = 0.44, P < 0.0001), systolic blood pressure (r = 0.55, P < 0.0001), diastolic blood pressure (r = 0.42, P < 0.0001), albuminuria (r = 0.24, P < 0.0001) and HbA1C (r = 0.11, P < 0.05). Albuminuria revealed an independent significant association with baPWV (P < 0.01) after adjustment for age, sex, smoking, BMI, HbA1C, hyperlipidemia, and hypertension. Multiple regression analysis showed age, diastolic blood pressure and albuminuria were independently associated with baPWV (adjusted R2 = 0.42, P < 0.0001).
Conclusions The results might indicate a possible link between the pathogenesis of atherosclerosis and diabetic nephropathy. Future studies are needed to clarify the usefulness and its predictable value.