A Comparison of Biological Activities of a New Soya Biopeptide Studied in an In Vitro Skin Equivalent Model and Human Volunteers
Article first published online: 24 DEC 2001
International Journal of Cosmetic Science
Volume 21, Issue 5, pages 299–311, October 1999
How to Cite
Andre-Frei, V., Perrier, E., Augustin, C., Damour, O., Bordat, P., Schumann, K., Förster, TH. and Waldmann-Laue, M. (1999), A Comparison of Biological Activities of a New Soya Biopeptide Studied in an In Vitro Skin Equivalent Model and Human Volunteers. International Journal of Cosmetic Science, 21: 299–311. doi: 10.1046/j.1467-2494.1999.211929.x
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
- Cited By
- skin equivalent model;
- in vivo study;
- extracellular matrix synthesis;
During aging, the epidermis and dermis become thin and an efficient anti-aging product should be able to stimulate the metabolism of senescent fibroblast and keratinocytes, in order to increase the quantity of extra-cellular matrix components such as collagen and glycosaminoglycans. A study performed in parallel on an in vitro skin equivalent model, and in vivo, with human volunteers, demonstrated the efficacy of one specific soya biopeptide for anti-aging properties.
Such a biopeptide induces a significant increase of glycosaminoglycans synthesis in vitro and in vivo after a one-month treatment. We also showed that this new cosmetic ingredient is able to stimulate favourably the collagen synthesis in vitro and in vivo.
This study provided the proof for anti-aging properties of a new soya biopeptide and also validated the skin equivalent model developed for this experimentation as an alternative method to animal or human testing for some cosmetic efficacy evaluations.