Article first published online: 20 DEC 2001
Volume 2, Issue 3, pages 166–173, July 2001
How to Cite
Mallon, P., Cooper, D. and Carr, A. (2001), HIV-associated lipodystrophy. HIV Medicine, 2: 166–173. doi: 10.1046/j.1468-1293.2001.00071.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Received: 4 April 2001, accepted 30 April 2001
The HIV associated lipodystrophy syndrome is characterized by fat loss from the periphery, fat accumulation in the abdominal, dorsocervical regions and breasts, and hyperlipidaemia, insulin resistance and lactic acidaemia. Although several mechanisms have been proposed to explain these abnormalities, the exact aetiology of the condition remains unclear and will likely prove to be complex. The principal clinical concerns that arise from this disorder are possible increased risks of premature atherosclerosis and cardiovascular disease. A variety of therapeutic interventions, designed to limit these risks, are under evaluation.