Cluster headache


Stephen D. Silberstein MD, FACP, Thomas Jefferson University Hospital, Jefferson Headache Center, Gibbon Building, Suite #8130, 111 South Eleventh Street, Philadelphia, PA 19107, USA. Tel. 215 955 2243, fax 215 955 6682, e-mail


Cluster headache is a stereotypic, primary headache disorder that is marked by repeated short-lasting attacks of severe, unilateral head pain and associated autonomic symptoms. Cluster headache is probably due to an abnormality in the circadian hypothalamic generator with subsequent trigeminovascular activation. We have reviewed the clinical manifestations, pathophysiology, gender differences, and treatment options in cluster headache.