Adhesion molecule profiles in atopic dermatitis vs. allergic contact dermatitis: pharmacological modulation by cetirizine
Version of Record online: 8 MAY 2002
Journal of the European Academy of Dermatology and Venereology
Volume 14, Issue 4, pages 263–266, July 2000
How to Cite
Boone, M., Lespagnard, L., Renard, N., Song, M. and Rihoux, J. (2000), Adhesion molecule profiles in atopic dermatitis vs. allergic contact dermatitis: pharmacological modulation by cetirizine. Journal of the European Academy of Dermatology and Venereology, 14: 263–266. doi: 10.1046/j.1468-3083.2000.00017.x
- Issue online: 8 MAY 2002
- Version of Record online: 8 MAY 2002
- Received: 4 October 1999,accepted 10 December 1999
- atopic dermatitis;
- allergic contact dermatitis;
- adhesion molecules;
Experimental data suggest that there is an imbalance between Th1 and Th2 cells in atopic dermatitis (AD) skin compared to allergic contact dermatitis (ACD). This imbalance (Th2 and Th1 predominance, respectively) implies the production of different cytokines in these two conditions leading to different expression of adhesion molecules on skin endothelial cells.
The expression of VCAM-1 (IL-4/Th2-dependent) and ICAM-1 (INF-γ/IL-1) on dermal vessels was compared in six patients with AD and six patients with ACD. The effect of cetirizine, a highly selective H1-receptor antagonist on the expressions was studied.
Six patients with AD were challenged with Dermatophagoides pteronyssimus (DPT patch tests applied to clinically normal skin) and six patients with ACD challenged in the same way with allergens of the European standard series. Skin biopsies at challenged sites were performed before and 6, 24 and 48 h after challenge. The experiment was carried out under double-blind cross-over conditions during a 4-day treatment with a placebo and cetirizine.
In AD patients, the scores for both VCAM-1 and ICAM-1 were high before and after challenge. In ACD patients, the ICAM-1 score was high at each experimental time, but the VCAM-1 score, which was significantly lower before challenge, increased at 6, 24 and 48 h after challenge. The administration of cetirizine significantly reduced the VCAM-1 expression in AD patients at each experimental time.
It is concluded that the increased VCAM-1 expression in AD patients compared to ACD may reflect greater IL-4 and/or IL-13 production in situ. The study also confirms the existence of a modulating effect of cetirizine in vivo on adhesion molecule expression.