Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix

  1. Uwe Wollina1,2,
  2. Theodor Karamfilov1

Article first published online: 25 DEC 2001

DOI: 10.1046/j.1468-3083.2000.00019.x

Issue

Journal of the European Academy of Dermatology and Venereology

Journal of the European Academy of Dermatology and Venereology

Volume 14, Issue 3, pages 187–190, May 2000

Additional Information

How to Cite

Wollina, U. and Karamfilov, T. (2000), Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix. Journal of the European Academy of Dermatology and Venereology, 14: 187–190. doi: 10.1046/j.1468-3083.2000.00019.x

Author Information

  1. 1

    Department of Dermatology and Allergology Friedrich-Schiller-University of Jena, 07740 Jena, Germany.

  2. 2

    Corresponding author, tel. +49 3641 937357; fax +49 2642 937416; E-mail: uwol@derma.uni-jena.de

Publication History

  1. Issue published online: 19 APR 2002
  2. Article first published online: 25 DEC 2001
  3. Received: 2 June 1999,accepted 10 October 1999

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Keywords:

  • pyoderma gangrenosum;
  • mycophenolate mofetil;
  • hyaluronic acid;
  • autologous keratinocyte transplantation

Abstract

Pyoderma gangrenosum sometimes takes a recalcitrant course that is unresponsive to standard immunosuppression with corticosteroids and/or cyclosporin A. In these cases improvement of painful ulcerations is a therapeutic challenge. We report a 17-year-old boy with severe pyoderma gangrenosum treated successfully with mycophenolate mofetil and autologous keratinocyte transplantation using an esterified hyluronic acid delivery system.

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