• 1
    Uttley AH, Collins CH, Naidoo J et al Vancomycin-resistant enterococci. Lancet 1988; 1: 578.
  • 2
    Leclercq R, Derlot E, Duval J et al Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med 1988; 319: 15761.
  • 3
    Uttley AH, George RC, Naidoo J et al High-level vancomycin-resistant enterococci causing hospital infections. Epidemiol Infect 1989; 103: 17381.
  • 4
    Frieden TR, Munsiff SS, Low DE et al Emergence of vancomycin-resistant enterococci in New York City. Lancet 1993; 342: 769.
  • 5
    Biavasco F, Miele A, Vignaroli C et al Genotypic characterization of a nosocomial outbreak of vanA Enterococcus faecalis. Microb Drug Res 1996; 2: 2317.
  • 6
    Torell E, Fredlund H, Tornquist E et al Intrahospital spread of vancomycin-resistant Enterococcus faecium in Sweden. Scand J Infect Dis 1997; 29: 25963.
  • 7
    Budavari SM, Saunders GL, Liebowitz LD et al Emergence of vanco-mycin-resistant enterococci in South Africa. S Afr Med J 1997; 87: 1557.
  • 8
    Ofner-Agostini ME, Conly J, Paton S et al Vancomycin-resistant enterococci (VRE) in Canada—results of the Canadian nosocomial infection surveillance program 1996 VRE point prevalence surveillance project. Can J Infect Dis 1997; 8: 738.
  • 9
    Bell JM, Paton JC, Turnidge J. Emergence of vancomycin-resistant enterococci in Australia: phenotypic and genotypic characteristics of isolates. J Clin Microbiol 1998; 36: 218790.
  • 10
    Hsueh PR, Teng LJ, Pan HJ et al Emergence of vancomycin-resistant enterococci at a university hospital in Taiwan: persistence of multiple species and multiple clones. Infect Control Hosp Epidemiol 1999; 20: 82833.
  • 11
    Suppola JP, Kolho E, Salmenlinna S et al vanA and vanB incorporate into an endemic ampicillin-resistant vancomycin-sensitive Enterococcus faecium strain: effect on interpretation of clonality. J Clin Microbiol 1999; 37: 39349.
  • 12
    Platsouka ED, Dimopoulou H, Miriagou V et al The first clinical isolates of Enterococcus faecium with the VanA phenotype in a tertiary Greek hospital. J Antimicrob Chemother 2000; 46: 103940.
  • 13
    Darini ALC, Zanella RC, Brandieone MCC et al Molecular analysis of vanA elements from strains of Enterococcus faecium and Enterococcus faecalis isolated during the first outbreak of glycopeptide resistant enterococci in Brazil. In: Program and Abstracts of the 1st International ASM Conference on Enterococci, Banff, Alberta, Canada. Washington, DC: American Society for Microbiology, 2000.
  • 14
    Sahm DF. Antimicrobial resistance among enterococci: A view from US clinical laboratories. In: Program and Abstracts of the 1st International ASM Conference on Enterococci, Banff, Alberta, Canada. Washington, DC: American Society for Microbiology, 2000.
  • 15
    Henwood CJ, Livermore DM, Johnson AP et al Susceptibility of Gram-positive cocci from 25 UK hospitals to antimicrobial agents including linezolid. J Antimicrobial Chemother 2000; 46: 93140.
  • 16
    Schouten MA, Voss A, Hoogkamp Korstanje JA, European VRE Study Group. Antimicrobial susceptibility patterns of enterococci causing infections in Europe. Antimicrob Agents Chemother 1999; 43: 25426.
  • 17
    Leclercq R, Derlot E, Weber M et al Transferable vancomycin and teicoplanin resistance in Enterococcus faecium. Antimicrob Agents Chemother 1989; 33: 105.
  • 18
    Noble WC, Virani Z, Cree RGA. Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NTCT 12201 to Staphylococcus aureus. FEMS Microbiol Lett 1992; 93: 1958.
  • 19
    Arthur M, Molinas C, Depardieu F et al Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol 1993; 175: 11727.
  • 20
    Biavasco F, Giovanetti E, Miele A et al In vitro conjugative transfer of VanA vancomycin resistance between Enterococci and Listeriae of different species. Eur J Clin Microbiol Infect Dis 1996; 15: 509.
  • 21
    Power EG, Abdulla YH, Talsania HG et al vanA genes in vancomycin-resistant clinical isolates of Oerskovia turbata and Arcanobacterium (Corynebacterium) haemolyticum. J Antimicrob Chemother 1995; 36: 595606.
  • 22
    Fontana R, Ligozzi M, Pedrotti C et al Vancomycin-resistant Bacillus circulans carrying the vanA gene responsible for vancomycin resistance in enterococci. Eur J Clin Microbiol Infect Dis 1997; 16: 4734.
  • 23
    Poyart C, Pierre C, Quesne G et al Emergence of vancomycin resistance in the genus Streptococcus: characterization of a vanB transferable determinant in Streptococcus bovis. Antimicrob Agents Chemother 1997; 41: 249.
  • 24
    McDonald LC, Kuehnert MJ, Teniver F et al Vancomycin-resistant enterococci outside the health-care setting: prevalence, sources, and public health implications. Emerg Inf Dis 1997; 3: 3117.
  • 25
    Witte W. Medical consequences of antibiotic use in agriculture. Science 1998; 279: 9967.
  • 26
    Woodford N. Glycopeptide-resistant enterococci. A decade of experience. J Med Microbiol 1998; 47: 84962.
  • 27
    Marrone WJ. Spread of vancomycin-resistant enterococci: why did it happen in the United States? Infect Control Hosp Epidemiol 1998; 19: 53945.
  • 28
    Goossens H. Spread of vancomycin-resistant enterococci: differences between the United States and Europe. Infect Control Hosp Epidemiol 1998; 19: 54651.
  • 29
    Wegener HC, Aarestrup FM, Jensen LB et al Use of antimicrobial growth promoters in food animals and Enterococcus faecium resistance to therapeutic antimicrobial drugs in Europe. Emerg Infect Dis 1999; 5: 32935.
  • 30
    Endtz HP, Van den Braak N, Verburgh HA et al Vancomycin resistance: Status quo and quo vadis. Eur J Clin Microbiol Infect Dis 1999; 18: 68390.
  • 31
    Van den Bogaard AE & Stobberingh EE. Epidemiology of resistance to antibiotics. Links between animals and humans. Int J Antimicrob Agents 2000; 14: 32735.
  • 32
    Aarestrup FM. Occurrence, selection and spread of resistance to antimicrobial agents used for growth promotion for food animals in Denmark. APMIS 2000; 108: S101.
  • 33
    Palmer SR, Soulsby L, Simpson DIH., eds. Preface. Zoonoses. Biology, clinical practice, and public health control. Oxford: Oxford University Press, 1998: XVIXIX.
  • 34
    Watanabe T & Fukasawa T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation. J Bacteriol 1961; 81: 66978.
  • 35
    Anderson ES & Datta N. Resistance to penicillins and its transfer in Enterobacteriaceæ. Lancet 1965; i: 4079.
  • 36
    Anderson ES & Lewis MJ. Drug resistance and its transfer in Salmonella typhimurium. Nature 1965; 206: 57983.
  • 37
    Smith HW. Antimicrobial drugs in animal feeds. Nature 1968; 218: 72831.
  • 38
    Swann MM. Report of the joint committee on the use of antibiotics in animal husbandry and veterinary medicine. London: Her Majesty’s Stationary Office; 1969.
  • 39
    Mølbak K, Baggesen DL, Aarestrup FM et al An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype Typhimurium DT104. N Engl J Med 1999; 341: 14205.
  • 40
    Endtz HP, Ruijs GJ, Van Klingeren B et al Quinolone resistance in Campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine. J Antimicrob Chemother 1991; 37: 11979.
  • 41
    Smith KE, Besser JM, Craig W et al Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992–98. N Engl J Med 1999; 340: 152532.
  • 42
    Levy SB, Fitzgerald GB, Macone AB. Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man. Nature 1976; 260: 402.
  • 43
    Marshall B, Petrowski D, Levy SB. Inter- and intraspecies spread of Escherichia coli in a farm environment in the abscence of antibiotic usage. Proc Natl Acad Sci USA 1990; 87: 660913.
  • 44
    Hummel R, Tschäpe H, Witte W. Spread of plasmid-mediated noursethricin resistance due to antibiotic use in animal husbandry. J Basic Microbiol 1986; 8: 4616.
  • 45
    Tschäpe H. The spread of plasmids as a function of bacterial adaptability. FEMS Microbiol Ecol 1994; 15: 2331.
  • 46
    Chaslus-Dancla E, Pohl P, Meurisse M et al High genetic homology between plasmids of human and animal origins conferring resistance to the aminoglycosides gentamicin and apramycin. Antimicrob Agents Chemother 1991; 35: 5903.
  • 47
    Werner G & Witte W. Characterization of a new enterococcal gene, sat G encoding a putative acetyltransferase conferring resistance to streptogramin A compounds. Antimicrob Agents Chemother 1999; 43: 18134.
  • 48
    Aarestrup FM, Bager F, Madsen M et al Surveillance of antimicrobial resistance in bacteria isolated from food animals to growth promoters and related therapeutic agents in Denmark. APMIS 1998; 106: 60622.
  • 49
    Hammerum AM, Jensen LB, Aarestrup FM. Presence of the satA gene encoding streptogramin A resistance in Enterococcus faecium from pigs and broilers. FEMS Microbiol Lett 1998; 168: 14551.
  • 50
    Welton LA, Thal LA, Perri MB et al Antimicrobial resistance in enterococci isolated from turkey flocks fed with virginiamycin. Antimicrob Agents Chemother 1998; 42: 7058.
  • 51
    Bates J, Jordens Z, Selkon JB. Evidence for an animal origin of vancomycin-resistant enterococci. Lancet 1993; 342: 4901.
  • 52
    Klare I, Heier H, Claus H et al Environmental strains of Enterococcus faecium with inducible high-level resistance to glycopeptides. FEMS Microbiol Lett 1993; 80: 239.
  • 53
    Bates J, Jordens JZ, Griffiths DF. Farm animals as a putative reservoir for vancomycin-resistant enterococcal infections in man. J Antimicrob Chemother 1994; 34: 50714.
  • 54
    Klare I, Heier H, Claus H et al vanA-mediated high-level glycopeptide resistance in Enterococcus faecium from animal husbandry. FEMS Microbiol Lett 1995; 125: 16571.
  • 55
    Torres C, Reguera RB, Sanmartin MJ et al vanA-mediated vancomycin-resistant Enterococcus spp. in sewage. J Antimicrob Chemother 1994; 33: 55361.
  • 56
    Klare I, Heier H, Claus H et al Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and faecal samples of humans in the community. Microb Drug Res 1995; 1: 26572.
  • 57
    Aarestrup FM. Occurrence of glycopeptide resistance among Enterococcus faecium isolates from conventional and ecological poultry farms. Microb Drug Res 1995; 1: 2557.
  • 58
    Aarestrup FM, Ahrens P, Madsen M et al Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the vanA cluster. Antimicrob Agents Chemother 1996; 40: 193840.
  • 59
    Bager F, Madsen M, Christensen J et al Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms. Prev Vet Med 1997; 31: 95112.
  • 60
    Kruse H, Johansen BK, Rørvik LM et al The use of avoparcin as a growth promoter and the occurrence of vancomycin-resistant Enterococcus species in Norwegian poultry and swine production. Microb Drug Res 1999; 5: 1359.
  • 61
    Yoshimura H, Ishimaru M, Endoh YS et al Isolation of glycopeptide-resistant enterococci from chickens in Japan. Antimicrob Agents Chemother 1998; 42: 3333.
  • 62
    Van den Bogaard AE, London N, Stobberingh EE. Antimicrobial resistance on pig faecal samples from the Netherlands (five abattoirs) and Sweden. J Antimicrobial Chemother 2000; 45: 66371.
  • 63
    Coque TM, Tomayko JF, Ricke SC et al Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States. Antimicrob Agents Chemother 1996; 40: 26059.
  • 64
    Wegener HC. Historical yearly usage of glycopeptides for animals and humans: the American-European paradox revisited. Antimicrob Agents Chemother 1998; 42: 3049.
  • 65
    Bager F, Aarestrup FM, Madsen M et al Glycopeptide resistance in Enterococcus faecium from broilers and pigs following discontinued use of avoparcin. Microb Drug Res 1999; 5: 536.
  • 66
    Pantostine A, Del Grosso M, Tagliabue S et al Decrease of vancomycin-resistant enterococci in poultry meat after avoparcin ban. Lancet 1999; 354: 7412.
  • 67
    Klare I, Badstubner D, Konstabel C et al Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry. Microb Drug Resist 1999; 5: 4552.
  • 68
    Borgen K, Simonsen GS, Sundsfjord A et al Continuing high prevalence of VanA-type vancomycin-resistant enterococci on Norwegian poultry farms three years after avoparcin was banned. J Appl Microbiol 2000; 89: 47885.
  • 69
    Borgen K, Sørum H, Kruse H et al Persistence of vancomycin-resistant enterococci (VRE) on Norwegian broiler farms. FEMS Microbiol Lett 2000; 191: 2558.
  • 70
    Smith HW. Persistence of tetracycline resistance in pig E. coli. Nature 1975; 258: 62830.
  • 71
    Van der Auwera P, Pensart N, Korten V et al Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci. J Infect Dis 1996; 173: 112936.
  • 72
    Endtz HP, Van den Braak N, Van Belkum A et al Faecal carriage of vancomycin-resistant enterococci in hospitalized patients and those living in community in The Netherlands. J Clin Microbiol 1997; 35: 302631.
  • 73
    Torell E, Cars O, Olsson-Liljequist B et al Near absence of vancomycin-resistant enterococci but high carriage rates of quinolone-resistant ampicillin-resistant enterococci among hospitalized patients and nonhospitalized individuals in Sweden. J Clin Microbiol 1999; 37: 350913.
  • 74
    Van den Bogaard AE, Jensen LB, Stobberingh EE. Vancomycin-resistant enterococci in turkeys and farmers. N Engl J Med 1997; 337: 15589.
  • 75
    Stobberingh E, Van den Bogaard A, London N et al Enterococci with glycopeptide resistance in turkeys, turkey farmers, turkey slaughterers, and (sub) urban residents in the south of The Netherlands: evidence for transmission from animals to humans? Antimicrob Agents Chemother 1999; 43: 221521.
  • 76
    Padiglione AA, Grabsch EA, Olden D et al Fecal colonization with vancomycin-resistant enterococci in Australia. Emerg Inf Dis 2000; 6: 5345.
  • 77
    Gordts B, Van Landuyt H, Ieven M et al Vancomycin-resistant enterococci colonizing the intestinal tracts of hospitalized patients. J Clin Microbiol 1995; 33: 28426.
  • 78
    Kjerulf A, Pallesen L, Westh H. Vancomycin-resistant enterococci at a large University hospital in Denmark. APMIS 1996; 104: 4759.
  • 79
    Boisivon A, Thibault T, Leclercq R et al Colonization by vancomycin-resistant enterococci of the intestinal tract of patients in intensive care units from French general hospitals. Clin Microbiol Infec 1997; 3: 1759.
  • 80
    Gambarotto K, Ploy MC, Turlure P et al Prevalence of vancomycin-resistant enterococci in fecal samples from hospitalized patients and nonhospitalized controls in a cattle-rearing area of France. J Clin Microbiol 2000; 38: 6204.
  • 81
    Van den Braak N, Ott A, van Belkum A et al Prevalence and determinants of fecal colonization with vancomycin-resistant Enterococcus in hospitalized patients in The Netherlands. Infect Control Hosp Epidemiol 2000; 21: 5204.
  • 82
    Schouten MA, Voss A, Hoogkamp Korstanje JA. VRE and meat. Lancet 1997; 349: 1258.
  • 83
    Van den Braak N, Kreft D, Van Belkum A et al Vancomycin-resistant enterococci in vegetarians. Lancet 1997; 350: 1467.
  • 84
    Simonsen GS, Andersen BM, Digranes A et al A low faecal carrier rate of vancomycin resistant enterococci in Norwegian hospital patients. Scand J Inf Dis 1998; 30: 4658.
  • 85
    Morris JG, Shay DK, Hebden JN et al Enterococci resistant to multiple antimicrobial agents including vancomycin. Establishment of endemicity in a University medical center. Ann Intern Med 1995; 123: 2509.
  • 86
    Silverman J, Thal LA, Perri MB et al Epidemiological evaluation of antimicrobial resistance in community-acquired enterococci. J Clin Microbiol 1998; 36: 8302.
  • 87
    Handwerger S, Raucher B, Altarac D et al Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin Inf Dis 1993; 16: 7505.
  • 88
    Whitman MS, Pitsakis PG, DeJesus E et al Gastrointestinal tract colonization with vancomycin-resistant Enterococcus faecium in an animal model. Antimicrob Agents Chemother 1996; 40: 152630.
  • 89
    Landman D, Quale JM, Oydna E et al Comparison of five selective media for identifying fecal carriage of vancomycin-resistant enterococci. J Clin Microbiol 1996; 34: 7512.
  • 90
    Wegener HC, Madsen M, Nielsen N et al Isolation of vancomycin resistant Enterococcus faecium from food. Int J Food Microbiol 1997; 35: 5766.
  • 91
    Aarestrup FM. Characterization of glycopeptide-resistant Enterococcus faecium (GRE) from broilers and pigs in Denmark: Genetic evidence that persistence of GRE in pig herds is associated with coselection by resistance to macrolides. J Clin Microbiol 2000; 38: 27747.
  • 92
    Stiles ME, Ramij NW, Ng LK et al Incidence and relationship of group D streptococci with other indicator organisms in meat. Can J Microbiol 1978; 24: 15028.
  • 93
    Kearns AM, Freeman R, Lightfoot NP. Nosocomial enterococci. resistance to heat and sodium hypochlorite. J Hosp Inf 1995; 30: 93199.
  • 94
    Noskin GA, Stosor V, Cooper I et al Recovery of vancomycin-resistant enterococci on fingertips and environmental surfaces. Infect Control Hosp Epidemiol 1995; 16: 57781.
  • 95
    Quednau M, Ahrne S, Petersson AC et al Antibiotic resistant strains of Enterococcus isolated from Swedish retailed chicken and pork. J Appl Microbiol 1998; 84: 116370.
  • 96
    Alcid DV, Troke M, Anuzewski S et al Probiotics as a source of Enterococcus Faecium[abstract 123]. Program and Abstract of the 32nd Infectious Diseases Society of America Annual Meeting, Orlando, FL.
  • 97
    Holzapfel WH, Franz CMA, Kalantzopoulos G. ‘Enterococci in food fermentations. Functional and safety aspects’. A European Commission shared cost research project funded within the fair program. In: Program and Abstracts of the 1st International ASM Conference on Enterococci, Banff, Alberta, Canada. Washington, DC: American Society for Microbiology, 2000.
  • 98
    Devriese LA, Ieven M, Goossens H et al Presence of vancomycin-resistant enterococci in farm and pet animals. Antimicrob Agents Chemother 1996; 40: 22857.
  • 99
    Van Belkum A, Van den Braak N, Thomassen R et al Vancomycin-resistant enterococci in cats and dogs. Lancet 1996; 348: 10389.
  • 100
    Simonsen GS, Haaheim H, Dahl KH et al Transmission of VanA-type vancomycin-resistant enterococci and vanA resistance elements between chicken and humans at avoparcin-exposed farms. Microb Drug Res 1998; 4: 3138.
  • 101
    Jensen LB, Hammerun AM, Pulsen RL et al Vancomycin-resistant Enterococcus faecium strains with highly similar pulsed-field gel electrophoresis patterns containing similar Tn1546-like elements isolated from a hospitalized patient and pigs in Denmark. Antimicrob Agents Chemother 1999; 43: 7245.
  • 102
    Berchieri A Jr. Intestinal colonization of a human subject by vancomycin-resistant Enterococcus faecium. Clin Microbiol Infect 1999; 5: 97100.
  • 103
    Blom M, Sørensen TL, Poulsen RL et al Ingestion of vancomycin-resistant Enterococcus faecium strains of food animal origin by human healthy volunteers: a randomized double-blind study [abstract 1692 ]. In: Programs and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada. Washington, DC: American Society for Microbiology, 2000: 432.
  • 104
    Devriese LA, Van de Kerckhove A, Klipper-Balz R et al Characterization and identification of Enterococcus species isolated from the intestines of animals. Int J Sys Bacteriol 1987; 37: 2579.
  • 105
    Devriese LA, Pot B, Collins MD. Phenotypic identification of the genus Enterococcus and differentiation of phylogenetically distinct enterococcal species and species groups. J Appl Bacteriol 1993; 75: 399408.
  • 106
    Willems R, Top J, Van den Braak N et al Host specificity of vancomycin-resistant Enterococcus faecium. J Infect Dis 2000; 182: 81623.
  • 107
    Handwerger S & Skoble J. Identification of chromosomal mobile element conferring high-level vancomycin resistance in Enterococcus faecium. Antimicrobial Agents Chemother 1995; 39: 244653.
  • 108
    Miele A, Bandera M, Goldstein B. Use of primers selective for vancomycin resistance genes to determine van genotype in enterococci and to study gene organization in VanA isolates. Antimicrob Agents Chemother 1995; 39: 17728.
  • 109
    Werner G, Klare I, Witte W. Arrangements of the vanA gene cluster in enterococci of different ecological origin. FEMS Microbiol Lett 1997; 155: 5561.
  • 110
    MacKinnon MG, Drebot MA, Tyrrell GJ. Identification and characterization of IS1476, an insertion sequence-like element that disrupts VanY function in a vancomycin-resistant Enterococcus faecium strain. Antimicrob Agents Chemother 1997; 41: 18057.
  • 111
    Jensen LB, Ahrens P, Dons L et al Molecular analysis of Tn1546 in Enterococcus faecium isolates from animals and humans. Antimicrob Agents Chemother 1998; 42: 50714.
  • 112
    Woodford N, Adebiyl AMA, Palepou MFI et al Diversity of VanA glycopeptide resistance elements in enterococci from humans and non-human sources. Antimicrob Agents Chemother 1998; 42: 5028.
  • 113
    Van den Braak, Van Belkum A, Van Keulen M et al Molecular characterization of vancomycin-resistant enterococci from hospitalized patients and poultry products in the Netherlands. J Clin Microbiol 1998; 36: 192732.
  • 114
    Simonsen GS, Myhre MRM, Dahl KH et al Typeability of Tn1546-like elements in vancomycin-resistant enterococci using long-range PCRs and specific analysis of polymorphic regions. Microb Drug Res 2000; 6: 4957.
  • 115
    Handwerger S, Skoble J, Discotto LF et al Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from northeastern United States. Antimicrob Agents Chemother 1995; 39: 3628.
  • 116
    Willems R, Top J, Van den Braak N, et alMolecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals. Antimicrob Agents Chemother 1999; 43: 48391.
  • 117
    Patel R, Uhl JR, Kohner P et al DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates. Antimicrob Agents Chemother 1998; 42: 2025.
  • 118
    Descheemaeker PR, Chapelle S, Devriese LA et al Comparison of glycopeptide-resistant Enterococcus faecium isolates and glycopeptide resistance genes of human and animal origins. Antimicrob Agents Chemother 1999; 43: 20327.
  • 119
    Woodford N, Watson AP, Chadwick PR. Investigation by long PCR of the genetic elements mediating VanA glycopeptide resistance in enterococci from uncooked meat in South Manchester, pp. 40912. In: Streptococci and the Host (Horaud T, Bouvet A, Leclercq R, de Montclos H, Sicard M, eds). New York: Plenum.
  • 120
    Haaheim H, Dahl KH, Simonsen GS et al Long PCRs of transposons in the structural analysis of genes encoding acquired glycopeptide resistance in enterococci. Biotechniques 1998; 24: 4327.
  • 121
    Palepou MFI, Adebiyi AMA, Tremlett CH et al Molecular analysis of diverse elements mediating VanA glycopeptide resistance in enterococci. J Antimicrob Chemother 1998; 42: 60512.
  • 122
    Darini ALD, Palepou MFI, Woodford N. Nucleotide sequence of IS1542, an insertion sequence identified within VanA glycopeptide resistance elements of enterococci. FEMS Microbiol Lett 1999; 173: 3416.
  • 123
    Jensen LB. Differences in the occurrence of two base pair variants of Tn1546 from vancomycin-resistant enterococci from humans, pigs, and poultry. Antimicrob Agents Chemother 1998; 42: 24634.
  • 124
    Dahl KH, Simonsen GS, Olsvik Ø et al Heterogeneity in the vanB gene cluster of genomically diverse clinical strains of vancomycin-resistant enterococci. Antimicrob Agents Chemother 1999; 43: 110510.
  • 125
    Schouten MA, Willems R, Kraak WAG et al Molecular analysis of Tn1546-like elements in vancomycin-resistant enterococci isolated from patients in Europe shows geographic transposon type clustering. Antimicrob Agents Chemother 2001; 45: 9869.
  • 126
    Patel R. Enterococcal-type glycopeptide resistance genes in non-enterococcal organisms. FEMS Microbiol Lett 2000; 185: 17.
  • 127
    Elisha BG & Courvalin P. Analysis of genes encoding D-alanine: D-alanine ligase-related enzymes in Leuconostoc mesenteroides and Lactobacillus spp. Gene 1995; 152: 7983.
  • 128
    Evers S, Casadewall B, Charles M et al Evolution of structure and substrate specificity in D-alanine: D-alanine ligases and related enzymes. J Mol Evol 1996; 42: 70612.
  • 129
    Park IS & Walsh CT. A-alanyl-D-lactate and D-alanyl-D-alanine synthesis by D-alanyl-D-alanine ligase from vancomycinresistant Leuconostoc mesenteroides. Effects of a phenylalanine 216 to tyrosine mutation. J Biol Chem 1997; 272: 92104.
  • 130
    Marshall CG, Broadhead G, Leskiw B et al D-Ala-D-Ala ligases from glycopeptide producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. Proc Natl Acad Sci USA 1997; 94: 64803.
  • 131
    Marshall CG, Lessard IAD, Park IS et al Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms. Antimicrob Agents Chemother 1998; 42: 221520.
  • 132
    Billot-Klein D, Gutmann L, Sable S et al Modification of peptidoglycan precursors is a common feature of the low-level vancomycin resistant VanB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum. J Bacteriol 1994; 176: 2398405.
  • 133
    Webb V & Davies J. Antibiotic preparations contain DNA. a source of drug resistance genes? Antimicrob Agents Chemother 1993; 37: 237984.
  • 134
    Rippere K, Patel R, Uhl JR et al DNA sequence resembling vanA and vanB in the vancomycin resistant biopesticide Bacillus popilliae. J Infect Dis 1998; 178: 5848.
  • 135
    Patel R, Piper K, Cockerill FC et al The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal vanA vancomycin resistance gene cluster. Antimicrob Agents Chemother 2000; 44: 7059.
  • 136
    McKessar SJ, Berry AM, Bell JM et al Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis. Antimicrob Agents Chemother 2000; 44: 32248.
  • 137
    Centers for Disease Control and Prevention. Nosocomial enterococci resistant to vancomycin – United States, 1989–93. Morb Mortal Wkly Rep 1993; 42: 5979.
  • 138
    Boyle JF, Soumakis SA, Rendo A et al Epidemiologic analysis and genotypic characterization of a nosocomial outbreak of vancomycin-resistant enterococci. J Clin Microbiol 1993; 31: 12805.
  • 139
    Clark NC, Cooksey RC, Hill BC et al Characterization of glycopeptide-resistant enterococci from US hospitals. Antimicrob Agents Chemother 1993; 37: 23117.
  • 140
    Shay DK, Maloney SA, Montecalvo M et al Epidemiology and mortality risk of vancomycin-resistant enterococcal bloodstream infections. J Inf Dis 1995; 172: 9931000.
  • 141
    Sader HS, Pfaller MA, Tenover FC et al Evaluation and characterization of multiresistant Enterococcus faecium from 12 U.S. medical centers. J Clin Microbiol 1994; 32: 28402.
  • 142
    Bais RK, Freundlich LF, Currie BP. Outpatient prevalence of vancomycin-resistant enterococcal (VRE) colonization in the catchment area of a hospital hyperendemic for VRE (Abstract). Infect Control Hosp Epidemiol 1996; 17: 20.
  • 143
    Bontin M, Slaughter S, Hayden M et al Patients’ endogenous flora as a source of ‘nosocomial’ vancomycin-resistant enterococci (VRE) [abstract 271]. In: Program and Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Canada. Washington, DC: American Society for Microbiology, 1996.
  • 144
    Mudd A. Vancomycin resistance and avoparcin. Lancet 1996; 347: 1412.
  • 145
    Phillips I. Assessing the evidence that antibiotic growth promoters influence human infections. J Hosp Infect 1999; 43: 1738.
  • 146
    Kirst HA, Thompson DG, Nicas TI. Historical yearly usage of vancomycin. Antimicrob Agents Chemother 1998; 42: 13034.
  • 147
    Ena J, Dick RW, Jones RN et al The epidemiology of intravenous vancomycin usage in a University hospital. A 10-year study. JAMA 1993; 269: 598602.
  • 148
    Simonsen GS. VanA-type glycopeptide resistant enterococci in Norway. Reservoirs – transmission – persistence. Thesis University of Tromsø2000. ISBN-82-7589-112-4.
  • 149
    Carias LL, Rudin SD, Donskey CJ et al Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate. J Bacteriol 1998; 180: 442634.
  • 150
    De Lencastre H, Brown AE, Chung M et al Role of transposon Tn5482 in the epidemiology of vancomycin-resistant Enterococcus faecium in the pediatric oncology unit of a New York City hospital. Microb Drug Res 1999; 5: 11329.
  • 151
    Report of the Joint Expert Technical Advisory Committee on Antibiotic Resistance (JETACAR). The Use of Antibiotics in Food-Producing Animals: Antibiotic-Resistant Bacteria in Animals and Humans. Australia: Commonwealth Department of Health and Aged Care. Commonwealth Department of Agriculture, Fisheries and Forestry, 1999.
  • 152
    Collignon PJ. Vancomycin-resistant enterococci and use of avoparcin in animal feed: is there a link? Med J Aust 1999; 171: 1446.
  • 153
    Turnidge J & Howard R. Australia’s antibiotic burden. Microbiol Aust 1996; 17: 11.
  • 154
    Dutka-Malen S, Leclercq R, Coutant V et al Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria. Antimicrob Agents Chemother 1990; 34: 18759.
  • 155
    Werner G, Klare I, Witte W. Large conjugative vanA plasmids in vancomycin-resistant Enterococcus faecium. J Clin Microbiol 1999; 37: 23834.
  • 156
    Heaton MP, Discotto LF, Pucci MJ et al Mobilization of vancomycin resistance by transposon-mediated fusion of a VanA plasmid with an Enterococcus faecium sex pheromone-response plasmid. Gene 1996; 171: 917.
  • 157
    Dahl KH, Røkenes TP, Midtvedt T et al In vivo transfer of the vanA gene cluster in the intestinal tract of germfree animals. Clin Microbiol Infect 1999; 5: 121.
  • 158
    Engel HWB, Soedirman N, Rost JA et al Transferability of macrolide, lincomycin, and streptogramin resistances between group A, B, and D streptococci, Streptococcus pneumoniae, and Staphylococcus aureus. J Bacteriol 1980; 142: 40713.
  • 159
    Schaberg DR, Clewell DB, Glatzer L. Conjugative transfer of R-plasmids from Streptococcus faecalis to Staphylococcus aureus. Antimicrob Agents Chemother 1982; 22: 2047.
  • 160
    Lyon BR & Skurray R. Antimicrobial resistance in Staphylococcus aureus: Genetic basis. Microbiol Rev 1987; 51: 88134.
  • 161
    Murray BE. The life and times of the enterococcus. Clin Microbiol Rev 1990; 3: 4665.
  • 162
    Clewell DB, An FY, White BA et al Streptococcus faecalis sex pheromone (cAM373) also produced by Staphylococcus aureus and identification of a conjugative transposon (Tn918). J Bacteriol 1985; 162: 121220.
  • 163
    Muscholl-Silberhorn A, Samberger E, Wirth R. Why does Staphylococcus aureus secrete an Enterococcus faecalis-specific pheromone? FEMS Microbiol Lett 1997; 157: 2616.
  • 164
    Das I, Fraise A, Wise R. Are glycopeptide-resistant enterococci in animals a threat to human beings? Lancet 1997; 349: 9978.
  • 165
    Hektonen H, Berge JA, Hormazabal V et al Persistence of antibacterial agents in marine sediments. Aquaculture 1995; 133: 17584.
  • 166
    Martens R, Wetzstein HG, Zadrazil F et al Degradation of the fluoroquinolone enrofloxacin by wood-rotting fungi. Appl Environ Microbiol 1996; 62: 42069.
  • 167
    Malabarba A, Nicas TI, Thompson RC. Structural modification of glycopeptide antibiotics. Med Res Rev 1997; 117: 69113.
  • 168
    Wetzstein HG, Stadler M, Tichy HV, Dalhoff A, Karl W. Degradation of ciprofloxacin by basidiomycetes and identification of metabolites by the brown rot fungus Gloeophyllum striatum. Appl Environ Microbiol 1999; 65: 155663.
  • 169
    Acar J, Casewell M, Freeman J et al Avoparcin and virginiamycin as animal growth promoters: a plea for science in decision-making. Clin Microbiol Infect 2000; 6: 47782.
  • 170
    Courvalin P. Will avilamycin convert Ziracine into Zerocine? Emerg Infect Dis 2000; 6: 558.
  • 171
    Falkow S & Kennedy D. Antibiotics, animals, and people-again! Science 2001; 291: 397.
  • 172
    Wegener HC. Casting pills before swine. Newsweek 2001, January 22, 2.
  • 173
    The medical impact of the use of antimicrobials in food animals.Report from a WHO Meeting; Berlin, Germany 1997 October 13–17. Geneva: World Health Organization, 1997.
  • 174
    Roberts MC, Sutcliffe J, Courvalin P et al Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob Agents Chemother 1999; 43: 282330.
  • 175
    Putman M, van Veen HW, Konings WN. Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev 2000; 64: 67293.
  • 176
    Rowe-Magnus DA & Mazel D. Resistance gene capture. Curr Opin Microbiol 1999; 2: 4838.
  • 177
    Hall RM & Stokes HW. Integrons: novel DNA elements which capture genes by site-specific recombination. Genetica 1993; 90: 11532.
  • 178
    Nesvera J, Hochmannova J, Patek M. An integron of class 1 is present on the plasmid pCG4 from Gram-positive bacterium Corynebacterium glutamicum. FEMS Microbiol Lett 1998; 169: 3915.
  • 179
    Ridley A & Threlfall EJ. Molecular epidemiology of antibiotic resistance genes in multiresistant epidemic Salmonella enterica Typhimurium DT104. Microb Drug Res 1998; 4: 1138.
  • 180
    Sandvang D, Aarestrup FM, Jensen LB. Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104. FEMS Microbiol Lett 1998; 170: 3741.
  • 181
    Briggs CE & Fratamico PM. Molecular characterization of an antibiotic resistance gene cluster in Salmonella typhimurium DT104. Antimicrob Agents Chemother 1999; 43: 8469.