Ultrasonographic and radiologic visualization of the developing embryonic skeleton

Authors

  • Dr R. M. van Zalen-Sprock,

    Corresponding author
    1. Division of Prenatal Diagnosis, Department of Obstetrics and Gynecology, University Hospital ‘Vrije Universiteit’, Amsterdam, The Netherlands
    • Division of Prenatal Diagnosis, Department of Obstetrics and Gynecology, University Hospital‘Vrije Universiteit’, Postbox 7057, 1007 MB Amsterdam, The Netherlands
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  • J. T. J. Brons,

    1. Department of Obstetrics and Gynecology, University of Utrecht, Utrecht, The Netherlands
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  • J. M. G. van Vugt,

    1. Division of Prenatal Diagnosis, Department of Obstetrics and Gynecology, University Hospital ‘Vrije Universiteit’, Amsterdam, The Netherlands
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  • H. J. van der Harten,

    1. Department of Pathology, University Hospital ‘Vrije Universiteit’, Amsterdam, The Netherlands
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  • H. P. van Geijn

    1. Division of Prenatal Diagnosis, Department of Obstetrics and Gynecology, University Hospital ‘Vrije Universiteit’, Amsterdam, The Netherlands
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Abstract

We investigated the development of the skeleton in the embryonic and early fetal period both with ultrasonography and radiology. Eight normal embryos/fetuses were studied weekly with real-time transvaginal sonography between 8 and 16 weeks of gestation to establish the ultrasonographic characteristics of normal ossification. Additionally, ossification was studied in radiographs obtained from five embryos/fetuses between 9 and 14 weeks of gestation.

Ossification centers, visualized as increased echogenicity of the bones, were recognized with ultrasonography from 9 weeks onwards. The appearance of primary ossification centers as observed by transvaginal ultrasonography was at the same gestational age or at most 1 week later than when obtained with radiography or whole-specimen staining techniques.

Transvaginal ultrasonography enables early visualization of ossification centers in the embryo and fetus. Detailed knowledge of the development of ossification of the skeleton may contribute to early prenatal diagnosis of skeletal dysplasias. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology

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