Dandy–Walker malformation diagnosed before 21 weeks of gestation: associated malformations and chromosomal abnormalities

Authors

  • Dr B. Ulm,

    Corresponding author
    1. Department of Obstetrics and Gynecology, Division of Prenatal Diagnosis and Therapy, University Hospital of Vienna, Vienna, Austria
    • Department of Obstetrics and Gynecology, Division of Prenatal Diagnosis and Therapy, University Hospital of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
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  • M. R. Ulm,

    1. Department of Obstetrics and Gynecology, Division of Prenatal Diagnosis and Therapy, University Hospital of Vienna, Vienna, Austria
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  • J. Deutinger,

    1. Department of Obstetrics and Gynecology, Division of Prenatal Diagnosis and Therapy, University Hospital of Vienna, Vienna, Austria
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  • G. Bernaschek

    1. Department of Obstetrics and Gynecology, Division of Prenatal Diagnosis and Therapy, University Hospital of Vienna, Vienna, Austria
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Abstract

This study examined rates of concomitant structural and chromosomal abnormalities in 14 fetuses with a diagnosis of Dandy-Walker malformation or Dandy-Walker variant before 21 weeks' gestational age, compared to 14 fetuses with a diagnosis of Dandy–malformation or variant between 21 weeks' gestation and delivery. A total of 24 fetuses had Dandy–malformation and four had Dandy–variant. Eight of the fetuses with the malformation had ventriculomegaly: one of the fetuses with early diagnosis and seven with later diagnosis (p = 0.027). None of the fetuses with Dandy-Walker variant had ventriculomegaly. The overall prevalence of concomitant structural abnormalities was 13/28; 8/l4 for fetuses with early prenatal diagnosis and 5/l4 for fetuses with late prenatal diagnosis of the malformation or the variant. Chromosomal abnormality rates were significantly higher among fetuses with early prenatal diagnosis (7/l 4) than among those with later prenatal diagnosis (l/l4; p = 0.032). Abnormal karyotypes were more prevalent among fetuses without ventriculomegaly (7/20), compared to fetuses with ventriculomegaly (l/8).

We conclude that fetuses with an antenatal diagnosis of Dandy-Walker malformation or Dandy-Walker variant before 21 weeks' gestational age have worse prognosis than fetuses with a later prenatal diagnosis of the same defect. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology

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