Prenatal diagnosis of trisomy 18 at the 10–14-week ultrasound scan

Authors

  • C. Sherod,

    1. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
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  • N. J. Sebire,

    1. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
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  • W. Soares,

    1. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
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  • R. J. M. Snijders,

    1. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
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  • Professor K. H. Nicolaides

    Corresponding author
    1. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
    • Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK
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Abstract

A beneficial consequence of screening for trisomy 21 by a combination of maternal age and fetal nuchal translucency thickness (NT) at 1O–l4 weeks is the early diagnosis of trisomy 18. In a multicenter study of 91 091 singleton pregnancies there were 106 fetuses with trisomy 18 and (83% were identified by NT screening. Trisomy 18 was also associated with early onset intrauterine growth retardation, decreased fetal heart rate and the presence of exomphalos. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology

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