Prognostic significance of ultrasound derived intratumoral peak systolic velocity in epithelial ovarian cancer
Article first published online: 17 DEC 2002
Copyright © 2002 International Society of Ultrasound in Obstetrics and Gynecology
Ultrasound in Obstetrics & Gynecology
Volume 20, Issue 2, pages 186–191, 1 August 2002
How to Cite
Hata, K., Yoshida, M., Maruyama, R., Fujiwaki, R. and Miyazaki, K. (2002), Prognostic significance of ultrasound derived intratumoral peak systolic velocity in epithelial ovarian cancer. Ultrasound Obstet Gynecol, 20: 186–191. doi: 10.1046/j.1469-0705.2002.00748.x
- Issue published online: 17 DEC 2002
- Article first published online: 17 DEC 2002
- Manuscript Accepted: 25 APR 2002
- Cited By
- Color Doppler imaging;
- Epithelial ovarian cancer;
- Multivariate Cox regression analysis;
- Peak systolic velocity;
- Pulsed Doppler spectral analysis
To evaluate the prognostic significance of ultrasound derived intratumoral peak systolic velocity in epithelial ovarian cancer.
Color Doppler imaging and pulsed Doppler spectral analysis were used in the investigation of 49 patients with epithelial ovarian cancer (19 serous, 15 mucinous, eight endometrioid, four clear cell and three Brenner cell) immediately before laparotomy. Twenty-two were stage I, six were stage II, 17 were stage III and four were stage IV. Sections of malignant tumors were analyzed for the cellular expression of thymidine phosphorylase and the intratumoral density of microvessels by immunohistochemistry using antibodies to thymidine phosphorylase and factor VIII-related antigen, respectively. Moreover, the apoptotic index was evaluated by the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling method. Intratumoral peak systolic velocity was tested for correlation with patients' age at diagnosis, stage of disease, presence of a residual tumor, histological subtype and grade, thymidine phosphorylase expression, apoptotic index, microvessel count and patient survival.
Histological grade (P = 0.025), thymidine phosphorylase expression (P = 0.044), apoptotic index (P = 0.039) and microvessel count (P = 0.014) were all significantly associated with peak systolic velocity. Stage of disease (P = 0.002), presence of residual disease (P = 0.0002) and peak systolic velocity (P = 0.041) were found by univariate Cox regression analysis to be significantly associated with a poor prognosis. Multivariate Cox regression analysis revealed that stage of disease (P = 0.006) and peak systolic velocity (P = 0.008) are independent prognostic factors.
Intratumoral peak systolic velocity could be a preoperatively pertinent prognostic predictor of survival in patients with epithelial ovarian cancer. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology