• 1
    Lamont RF. The pathophysiology of pulmonary oedema with the use of beta-agonists. Br J Obstet Gynaecol 2000;107: 439444.
  • 2
    Royal College of Obstetricians and GynaecologistsBeta-agonists for the care of women in labour. Guideline No. 1. London : RCOG Press, 1997.
  • 3
    Besinger RE, Iannucci TA. Tocolytic therapy. In: ElderMG, RomeroR, LamontRF editors. Preterm Labour. 1997: 243297Churchill Livingstone, New York :
  • 4
    Fuchs A-R, Fuchs F, Husslein P, Soloff MS, Fernstrom MJ. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiative of labor. Science 1982;215: 13961398.
  • 5
    Fuchs A-R, Behrens O, Liu HC. Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy. Am J Obstet Gynecol 1992;167: 159163.
  • 6
    Melin P. Development of an oxytocin antagonist—Atosiban. Res Clin Forums 1994;16: 155170.
  • 7
    Chibbar R, Miler FC, Mitchell BF. Synthesis of oxytocin in amnion, chorion and decidua may influence the timing of human parturition. J Clin Invest 1993;91: 185192.
  • 8
    Fuchs AR, Fuchs F. Endocrinology of human parturition: a review. Br J Obstet Gynaecol 1984;91: 948967.
  • 9
    Du Vigneaud V, Ressler C, Trippett S. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. J Biol Chem 1953;205: 949957.
  • 10
    Law HD, du Vigneaud V. Synthesis of 2p-methoxyphenylalanine oxytocin (O-Methyl-oxytocin) and some observations on its pharmacological behaviour. J Am Chem Soc 1960;82: 45794581.
  • 11
    Melin P, Vilhardt H, Lindeberg G, Larsson L-E, Akerlund M. Inhibitory effect of O-alkylated analogues of oxytocin and vasopressin on human and rat myometrial activity. J Endocrinol 1981;88: 173180.
  • 12
    Akerlund M, Stromberg P, Forsling ML, Melin P, Vilhardt H. Inhibition of vasopressin effects on the uterus by a synthetic analogue. Obstet Gynecol 1983;62: 309312.
  • 13
    Melin P, Trojnar J, Vilhardt H, Akerlund M. Uterotonic oxytocin and vasopressin antagonists with minimal structure modifications. In: HrubyVJ, RichDH. Peptides: Structure and Function Proceedings of the 8th American Peptide Symposium. Rockford , USA : Pierce Chemical, 1983: 361365.
  • 14
    Melin P, Trojnar J, Johansson B, Vilhardt H, Åkerlund M. Synthetic anatagonists of the myometrial response to vasopressin and oxytocin. J Endocrinol 1986;111: 125131.
  • 15
    Akerlund M, Carlsson AM, Melin P, Trojnar J. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand 1985;64: 499504.
  • 16
    Åkerlund M. Oxytocin antagonists in the treatment of preterm labour. Fet Mat Med Rev 2002;13: 3141.
  • 17
    Lamont RF, Greenfield P. Anti-oxytocic tocolytic agents. Yearbook of the Royal College of Obstetricians and Gynaecologists, 10. London : RCOG Press, 2002: 30140.
  • 18
    Phaneuf S, Asboth G, Mackenzie IZ, Melin P, Lopez-Bernal A. Effect of oxytocin antagonists on the activation of human myometrium in vitro: Atosiban prevents oxytocin-induced desensitisation. Am J Obstet Gynecol 1994;171: 16261634.
  • 19
    Akerlund M, Stromberg P, Hauksson A, et al. Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study. Br J Obstet Gynaecol 1987;94: 10401044.
  • 20
    Andersen L-F, Lyndrup J, Akerlund M, Melin P. Oxytocin receptor blockade: a new principle in the treatment of preterm labour. Am J Perinatol 1989;6: 196199.
  • 21
    The Canadian Preterm Labor Investigators GroupTreatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med 1992;327: 308312.
  • 22
    King J, Grant A, Keirse MJ, Chalmers I. Beta-mimetics in preterm labor: an overview of the randomized controlled trials. Br J Obstet Gynaecol 1988;95: 211222.
  • 23
    Goodwin TM, Paul RP, Silver H, et al. The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human. Am J Obstet Gynecol 1994;170: 474478.
  • 24
    Goodwin TM, Valenzuela GJ, Silver H, Creasy G, Atosiban Study GroupDose ranging study of the antagonist atosiban in the treatment of preterm labor. Obstet Gynecol 1996;88: 331336.
  • 25
    Romero R, Sibai BM, Sanchez-Ramos L, et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 2000;182: 11731183.
  • 26
    Valenzuela GJ, Sanchez-Ramos L, Romero R, et al. Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. Am J Obstet Gynecol 2000;182: 11841190.
  • 27
    The Worldwide Atosiban versus Beta-agonists Study GroupEffectiveness and safety of the oxytocin antagonist Atosiban versus beta-adrenergic agents in the treatment of preterm labour. Br J Obstet Gynaecol 2001;108: 133142.