Early invasive cervical adenocarcinoma: its potential for nodal metastasis or recurrence

Authors

  • Yasuo Hirai,

    Corresponding author
    1. Department of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
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  • Nobuhiro Takeshima,

    1. Department of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
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  • Shinichi Tate,

    1. Department of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
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  • Futoshi Akiyama,

    1. Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
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  • Reiko Furuta,

    1. Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
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  • Katsuhiko Hasumi

    1. Department of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
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* Dr Y. Hirai, Department of Gynecology, Cancer Institute Hospital, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.

Abstract

Objective To investigate the potential for nodal spread or recurrence in patients with early invasive cervical adenocarcinoma. The possible application of the International Federation of Gynecology and Obstetrics (FIGO) classification (1994) to this variant was also examined.

Design Retrospective observational study.

Setting Gynaecological oncology division of Cancer Institute Hospital, Japan.

Population 302 patients with FIGO Stage 0-IIB cervical adenocarcinoma treated surgically at the Cancer Institute Hospital.

Methods Clinicopathological analysis was performed on 47 patients with early invasive cervical adenocarcinoma in whom the depth of stromal invasion was 5 mm or less. All patients underwent radical hysterectomy and pelvic lymphadenectomy.

Results In 30 patients with a depth of tumour invasion of 3 mm or less, no lymph node metastasis was found, while two patients developed recurrence; one had a depth of invasion of 3 mm and a horizontal tumour spread of 3 mm, and the other had horizontal spread of more than 7 mm. In 17 patients with a depth of invasion from 3 to 5 mm, there was also no lymph node metastasis, but two patients developed recurrence; one had horizontal tumour spread of 7 mm or less, and the other had horizontal spread of more than 7 mm.

Conclusion Early invasive cervical adenocarcinoma with a depth of invasion of 3 mm or less and a horizontal spread of 7 mm or less has little potential for nodal metastasis or recurrence. It seems possible that the FIGO definition (1994) of early cervical cancer may be applicable in its present form to early cervical adenocarcinoma.

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