Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims
Article first published online: 23 NOV 2002
Journal of Neurochemistry
Volume 62, Issue 2, pages 680–685, February 1994
How to Cite
Ordway, G. A., Smith, K. S. and Haycock, J. W. (1994), Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims. Journal of Neurochemistry, 62: 680–685. doi: 10.1046/j.1471-4159.1994.62020680.x
- Issue published online: 23 NOV 2002
- Article first published online: 23 NOV 2002
- Received June 8, 1993; accepted June 25, 1993.
- Tyrosine hydroxylase;
- Locus coeruleus;
- Sudden death
Abstract: The amounts of tyrosine hydroxylase protein in locus coeruleus from nine pairs of antidepressant-free suicide victims and age-matched, sudden-death control cases were determined by quantitative blot immunolabeling of cryostat-cut sections from the caudal portion of the nucleus. In each of the nine age-matched pairs, the concentration of tyrosine hydroxylase was greater in the sample from the suicide victim, with values ranging from 108 to 172% of the matched control value (\-x = 136%). By contrast, there were no differences in the concentrations of neuron-specific enolase protein in the same set of samples. Similarly, the number of neuromelanin-containing cells, counted in sections of locus coeruleus adjacent to those taken for blot immunolabeling analyses, did not differ between the two groups. These data indicate that locus coeruleus neurons from suicide victims contain higher than normal concentrations of tyrosine hydroxylase, thus raising the possibility that the expression of tyrosine hydroxylase in locus coeruleus may be relevant in the pathophysiology of suicide.