Down's Syndrome: Up-Regulation of β-Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination
Article first published online: 28 JUN 2008
Journal of Neurochemistry
Volume 62, Issue 3, pages 1062–1066, March 1994
How to Cite
Oyama, F., Cairns, N. J., Shimada, H., Oyama, R., Titani, K. and Ihara, Y. (1994), Down's Syndrome: Up-Regulation of β-Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination. Journal of Neurochemistry, 62: 1062–1066. doi: 10.1046/j.1471-4159.1994.62031062.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Recieved May 27, 1993; revised July 20, 1993; accepted July 21, 1993.
- β-Amyloid protein precursor;
- Defective coordination;
- Down's syndrome;
Abstract: Almost all patients >40 years of age with Down's syndrome (DS) develop the pathology characteristic of Alzheimer's disease: abundant β-amyloid plaques and neurofibrillary tangles. We have investigated the gene expression of β-amyloid protein precursor (APR) and τ in DS and age-matched control brains and found that levels of both mRNAs were significantly elevated in DS. Such up-regulation was not observed in two other neuronal proteins. A correlation between total APP and τ mRNA levels was also found in DS brain but distinct from the pattern observed in normal brain. Although a proportionality existed between APP-695 mRNA and three-repeat τ mRNA in DS, the proportionality between APP-751 mRNA and four-repeat τ mRNA, which is normally present, was not observed. Thus, DS brains are primarily characterized by the up-regulation of τ mRNA as well as APP mRNA and disruption of the coordinate expression between APP-751 and four-repeat τ.