Dedicated to Daniel X. Freedman, in memoriam.
Autoradiographic Demonstration of Increased α2-Adrenoceptor Agonist Binding Sites in the Hippocampus and Frontal Cortex of Depressed Suicide Victims†
Article first published online: 23 NOV 2002
Journal of Neurochemistry
Volume 63, Issue 1, pages 256–265, July 1994
How to Cite
González, A. M., Pascual, J., Meana, J. J., Barturen, F., Del Arco, C., Pazos, A. and García-Sevilla, J. A. (1994), Autoradiographic Demonstration of Increased α2-Adrenoceptor Agonist Binding Sites in the Hippocampus and Frontal Cortex of Depressed Suicide Victims. Journal of Neurochemistry, 63: 256–265. doi: 10.1046/j.1471-4159.1994.63010256.x
- Issue published online: 23 NOV 2002
- Article first published online: 23 NOV 2002
- Received June 29, 1993; revised manuscript received October 25, 1993; accepted November 15, 1993.
- Suicide victims;
- Frontal cortex;
Abstract: To examine directly in the brain the status of α2-adrenoceptors in major depression, the specific binding of the agonist [3H]UK 14304 was measured by quantitative receptor autoradiography in the hippocampus and frontal cortex of suicide victims (n = 17) with a retrospective diagnosis of depression (n = 7) or other psychiatric disorders (n = 10) as well as of matched control subjects (n = 9). In suicide victims, a significant increase in the number of α2-adrenoceptors was found in the CA1 field (40%) and dentate gyrus (20%) of the hippocampus and in the external layers I (33%) and II (31%) of the frontal cortex, compared with that in matched controls. In depressed suicide victims, the increase in α2-adrenoceptors in the CA1 field (57%) was significantly greater (24%, p < 0.05) than that observed in the group of suicide victims with other diagnoses (26%). In the same depressed suicide victims, the increase in cortical α2-adrenoceptors was restricted to layer I (34%) and it was equivalent to that found in layer I (33%) of suicide victims with other diagnoses. The results indicate that suicide is associated with increases in the high-affinity state of brain α2-adrenoceptors and that there is a pronounced localized increase of this inhibitory receptor in the hippocampus of depressed suicide victims.