Correlative Regulation of Nerve Growth Factor Level and Choline Acetyltransferase Activity by Thyroxine in Particular Regions of Infant Rat Brain
Article first published online: 23 NOV 2002
Journal of Neurochemistry
Volume 63, Issue 1, pages 326–332, July 1994
How to Cite
Hashimoto, Y., Furukawa, S., Omae, F., Miyama, Y. and Hayashi, K. (1994), Correlative Regulation of Nerve Growth Factor Level and Choline Acetyltransferase Activity by Thyroxine in Particular Regions of Infant Rat Brain. Journal of Neurochemistry, 63: 326–332. doi: 10.1046/j.1471-4159.1994.63010326.x
- Issue published online: 23 NOV 2002
- Article first published online: 23 NOV 2002
- Received September 21, 1993; revised manuscript received November 24, 1993; accepted November 26, 1993.
- Nerve growth factor;
- Choline acetyltransferase;
- Cholinergic neurons
Abstract: Effects of thyroxine (T4) on nerve growth factor (NGF) level and choline acetyltransferase (ChAT) activity of rat brains were investigated. Repetitive intraperitoneal administration of T4 caused increases in both NGF level and ChAT activity in the frontal cortex, septum, hippocampus, and striatum and decreases in the cerebellum in 2-day-old rats. Only ChAT activity was elevated in the olfactory bulb, and the NGF level remained unchanged there. No changes were observed in the midbrain and pons/medulla. Furthermore, T4 was effective on the post-natal rats only up to day 11. These results suggest that T4 plays a role in the developmental regulation of NGF level and ChAT activity in rat brain in a region- and/or stage-specific manner. That (1) changes in NGF level and ChAT activity occurred in regions nearly identical to those that contained NGF-responding neurons, and (2) the change in NGF level in the hippocampus and frontal cortex was followed by the change of ChAT activity after a single injection of T4 suggest that the effects of T4 on cholinergic differentiation are, at least in part, mediated via NGF, which itself is quantitatively regulated by T4.