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Keywords:

  • Antibody;
  • GABA receptor;
  • Benzodiazepine receptor;
  • Subunit;
  • Cerebellum;
  • Ro 15-4513

Abstract: The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have α6, α1, γ2S, γ2L, and β2 or β3 subunits colocalizing in the same receptor complex.