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The Subunit Composition of a GABAA/Benzodiazepine Receptor from Rat Cerebellum

Authors

  • Zafar U. Khan,

    1. Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri, U.S.A.
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  • Antonia Gutierrez,

    1. Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri, U.S.A.
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  • Angel L. De Blas

    Corresponding author
    1. Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri, U.S.A.
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Address correspondence and reprint requests to Dr. A. L. De Blas at Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110-2499, U.S.A.

Abstract

Abstract: The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have α6, α1, γ2S, γ2L, and β2 or β3 subunits colocalizing in the same receptor complex.

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