Characterization of a Novel Platelet-Derived Growth Factor-Associated Protein
Article first published online: 23 NOV 2002
Journal of Neurochemistry
Volume 66, Issue 5, pages 2213–2216, May 1996
How to Cite
Fischer, W. H. and Schubert, D. (1996), Characterization of a Novel Platelet-Derived Growth Factor-Associated Protein. Journal of Neurochemistry, 66: 2213–2216. doi: 10.1046/j.1471-4159.1996.66052213.x
- Issue published online: 23 NOV 2002
- Article first published online: 23 NOV 2002
- Resubmitted manuscript received February 8, 1996; accepted February 12, 1996.
- Platelet-derived growth factor;
- Binding protein;
- Secreted protein
Abstract: A novel mitogen-associated protein was isolated from a rat neural retina cell line. The protein copurified with platelet-derived growth factor (PDGF)-A and was therefore termed PDGF-associated protein (PAP). cDNAs corresponding to the protein were characterized from both rat and human cDNA libraries. PAP binds to PDGF with low affinity and enhances the mitogenic effect of PDGF-A but lowers the mitogenic activity of PDGF-B. PAP mRNA is abundant in the brain of newborn rats and is found in several other tissues.