The present address of Dr. T. D. Raabe is Department of Biological Sciences, St. Mary's University, One Camino Santa Maria, San Antonio, TX 78228, U.S.A.
Neonatal Oligodendrocytes Contain and Secrete Neuregulins In Vitro
Article first published online: 18 NOV 2002
Journal of Neurochemistry
Volume 69, Issue 5, pages 1859–1863, November 1997
How to Cite
Raabe, T. D., Clive, D. R., Wen, D. and DeVries, G. H. (1997), Neonatal Oligodendrocytes Contain and Secrete Neuregulins In Vitro. Journal of Neurochemistry, 69: 1859–1863. doi: 10.1046/j.1471-4159.1997.69051859.x
- Issue published online: 18 NOV 2002
- Article first published online: 18 NOV 2002
- Resubmitted manuscript received June 17, 1997; accepted June 18, 1997.
- Neu differentiation factor
Abstract: The factors that influence the development of oligodendrocyte (OLG) progenitors into mature OLGs remain elusive. Recent evidence has suggested that neu differentiation factor (NDF), which is a member of the neuregulin family of growth factors, influences the development of glial cells, including Schwann cells, astrocytes, and OLGs. Neurons are postulated to be the source of neuregulins, because neurons closely interact with these glial cells during development. In this report, we have identified the mRNA for both isoform families of NDF in cultured neonatal (immature) OLGs. We have also demonstrated that cultured neonatal OLGs contain and secrete NDF protein. These data raise the possibility that NDF could be used in an autocrine/paracrine loop by neonatal OLGs during development for survival, proliferation, and/or differentiation.
Abbreviations used: ARIA, acetylcholine receptor-inducing activity; NDF, neu differentiation factor; NRG, neuregulin; OLG, oligodendrocyte; RT, reverse transcription.