SEARCH

SEARCH BY CITATION

Acknowledgements

We thank Dr. Bernard Thorens (Lausanne, Switzerland) for the gift of the pGLPR-1 plasmid and Dr. Thomas G. Sherman (Pittsburgh, PA, U.S.A.) for providing the plasmids containing the AVP and OX cDNAs. This work was supported by grants from the Dirección General de Investigación Científica y Técnica and from the Fondo de Investigación Sanitaria, Spain.

  • 1
    Alvarez E., Roncero I., Chowen J.A., Thorens B., Blázquez E. (1996) Expression of the glucagon-like peptide-1 receptor gene in rat brain.J. Neurochem. 66,920927.
  • 2
    Barragán J.M., Rodríguez R., Blázquez E. (1994) Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1(7-36)amide in rats.Am. J. Physiol. 266,E459E466.
  • 3
    Barragán J.M., Rodríguez R., Eng J., Blázquez E. (1996) Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1(7-36)amide and of exendin-4 on arterial blood pressure and heart rate in rats.Regul. Pept. 67,6368.
  • 4
    Beak S.A., Small C.J., Ilovaiskaia I., Hurley J.D., Ghatei M.A., Bloom S.R., Smith D.M. (1996) Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH) : characterization of binding sites for GLP-1 on α-TSH cells. Endocrinology 137,41304138.
  • 5
    Bondy C.A. & Gainer H. (1989) Corticotropin-releasing hormone stimulates neurohypophysial hormone release through an interaction with the intermediate lobe of the pituitary.J. Neuroendocrinol. 1,58.
  • 6
    Calvo J.C., Yusta B., Mora F., Blázquez E. (1995a) Structural characterization by affinity cross-linking of glucagon-like peptide-1(7-36)amide receptor in rat brain.J. Neurochem. 64,299306.
  • 7
    Calvo J.C., Gisolfi C.V., Blázquez E., Mora F. (1995b) Glucagon-like peptide-1(7-36)amide induces the release of aspartic acid and glutamine by the ventromedial hypothalamus of the conscious rat.Brain Res. Bull. 38,435439.
  • 8
    Chowen J.A., Argente J., González-Parra S., Garcia Segura L.M. (1993) Differential effects of neonatal and adult sex steroid environments on the organization and activation of hypothalamic growth hormone-releasing hormone and somatostatin neurons.Endocrinology 133,27922802.
  • 9
    Dillon J.S., Tanizawa Y., Wheeler M.B., Leng X.H., Ligon B.B., Rabin D.H., Yoo-Warren H., Permut M.A., Boyd A.E.III (1993) Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor.Endocrinology 133,19071910.
  • 10
    Drucker D.J., Ehrlich P., Asa S.L., Brubaker P.L. (1996) Induction of intestinal epithelial proliferation by glucagon-like peptide 2.Proc. Natl. Acad. Sci. USA 93,79117916.
  • 11
    Göke R., Fehmann H.C., Linn T., Schmidt H., Krause M., Eng J., Göke B. (1993) Exendin is a high potency agonist and truncated exendin(9-39)amide an antagonist at the glucagon-like peptide-1(7-36)amide receptor of insulin-secreting β-cells. J. Biol. Chem. 268,1965019655.
  • 12
    Göke R., Larsen P.J., Mikkelsen J.D., Sheikh S.P. (1995) Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary.Neuroendocrinology 62,130134.
  • 13
    Kanse S.M., Kreymann B., Ghatei M.A., Bloom S.R. (1988) Identification and characterization of glucagon-like peptide-1(7-36)amide-binding sites in rat brain and lung.FEBS Lett. 241,209212.
  • 14
    Koob G.F. & Bloom F.E. (1985) Corticotropin releasing factor and behavior.Fed. Proc. 44,259263.
  • 15
    Kreymann B., Williams G., Ghatei M.A., Bloom S.R. (1987) Glucagon-like peptide 1(7-36) : a physiological incretin in man.Lancet ii,13001304.
  • 16
    Larsen P.J., Tang-Christensen M., Jessop D.S. (1997) Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.Endocrinology 138,44454455.
  • 17
    Mora F., Exposito I., Sanz B., Blázquez E. (1992) Selective release of glutamine and glutamic acid produced by perfusion of GLP-1(7-36)amide in the basal ganglia of the conscious rat.Brain Res. Bull. 29,359361.
  • 18
    Navarro M., Rodríguez de Fonseca F., Alvarez E., Chowen J.A., Zueco J.A., Gomez R., Eng J., Blázquez E. (1996) Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells : evidence for a role of GLP-1 agonists as an inhibitory signal for food and water intake.J. Neurochem. 67,19821991.
  • 19
    Orskov C., Poulsen S.S., Moller M., Holst J.J. (1996) Glucagon-like peptide-1 receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide-1.Diabetes 45,832835.
  • 20
    O'Shea D., Gunn I., Chen X., Bloom S., Herbert J. (1996) A role for central glucagon-like peptide-1 in temperature regulation.Neuroreport 7,830832.
  • 21
    Richter G., Göke R., Göke B., Schmidt H., Arnold R. (1991) Characterization of glucagon-like peptide-1(7-36)amide receptors of rat lung membranes by covalent cross-linking.FEBS Lett. 280,247250.
  • 22
    Richter G., Feddersen O., Wagner U., Barth P., Göke R., Göke B. (1993) GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery.Am. J. Physiol. 265,L374L381.
  • 23
    Schjoldager B.T.G., Mortensen P.E., Christiansen J., Orskov C., Holst J.J. (1989) GLP-1 (glucagon-like peptide-1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans.Dig. Dis. Sci. 34,703708.
  • 24
    Tang-Christensen M., Larsen P.J., Göke R., Fink-Jensen A., Jessop D.S., Moller M., Sheikh S.P. (1996) Central administration of GLP-1(7-36)amide inhibits food and water intake in rats.Am. J. Physiol. 271,R848R856.
  • 25
    Thorens B. (1992) Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide-1.Proc. Natl. Acad. Sci. USA 89,86418645.
  • 26
    Thorens B., Porret A., Bühler L., Deng S.P., Morel P., Widruan C. (1993) Cloning and functional expression of the human islet GLP-1 receptor.Diabetes 42,16781682.
  • 27
    Turton M.D., O'Shea D., Gunn I., Beak S.A., Edwards C.M., Meeran K., Choi S.J., Taylor G.M., Heath M.M., Lambert P.D., Wilding J.P.H., Smith D.M., Ghatei M.A., Herbert J., Bloom S.R. (1996) A role for glucagon-like peptide-1 in the central regulation of feeding.Nature 379,6972.
  • 28
    Uttenthal L.O. & Blázquez E. (1990) Characterization of high affinity receptors for truncated-like peptide-1 in rat gastric glands.FEBS Lett. 262,139141.
  • 29
    Uttenthal L.O., Toledano A., Blázquez E. (1992) Autoradiographic localization of receptors for glucagon-like peptide-1(7-36)amide in rat brain.Neuropeptides 21,143146.
  • 30
    Valverde I., Mérida E., Delgado E., Trapote M.A., Villanueva-Peñacarrillo M.L. (1993) Presence and characterization of glucagon-like peptide-1(7-36)amide receptors in solubilized membranes of rat adipose tissue.Endocrinology 32,7579.
  • 31
    Wei Y. & Mojsov S. (1995) Tissue-specific expression of the human receptor for glucagon-like peptide-I : brain, heart and pancreatic forms have the same deduced amino acid sequences.FEBS Lett. 358,219224.
  • 32
    Wettergren A., Schjoldager B., Mortensen P.E., Myhre J., Christiansen J., Holst J.J. (1993) Truncated GLP-1 (proglucagon 72-107 amide) inhibits gastric and pancreatic functions in man.Dig. Dis. Sci. 38,665673.
  • 33
    Wolf M.E. & Roth R.M. (1987) Dopamine autoreceptors, inDopamine Receptors (Creese I. and Frazer C. M., eds), pp. 4162. Alan R. Liss, New York.