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Acknowledgements

We thank Dr. E. Hamel (Montreal Neurological Institute, McGill University) for the availability of postmortem human trigeminal ganglia. We also gratefully acknowledge the Astra Research Center in Montreal, the Medical Research Council of Canada (MRC), the Savoy Foundation for Epilepsy (SFE), the T2C2 Group, as well as the Fondation des Maladies du Coeur du Québec for their operating support. K.B. is an MRC-Astra postdoctoral Fellow, K.-T.L. holds a PhD studentship from the SFE, and P.S. is a junior Scholar from the Fonds de la Recherche en Santé du Québec.

  • 1
    Adams C.M., Anderson M.G., Motto D.G., Price M.P., Johnson W.A., Welsh M.J. (1998) Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons.J. Cell Biol. 140,143152.
  • 2
    Bassilana F., Champigny G., Waldmann R., De Weille J.R., Heurteaux C., Lazdunski M. (1997) The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.J. Biol. Chem. 272,2881928822.
  • 3
    Bertrand D., Cooper E., Valera S., Rungger D., Ballivet M. (1991) Electrophysiology of neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes following nuclear injection of genes or cDNAs, inMethods in Neurosciences (Conn M. P., ed), pp. 174193. Academic Press, San Diego.
  • 4
    Bevan S. & Winter J. (1995) Nerve growth factor (NGF) differentially regulates the chemosensitivity of adult rat cultured sensory neurons.J. Neurosci. 15,49184926.
  • 5
    Bevan S. & Yeats J. (1991) Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones.J. Physiol. (Lond.) 433,145161.
  • 6
    Canessa C.M., Merillat A.M., Rossier B.C. (1994a) Membrane topology of the epithelial sodium channel in intact cells.Am. J. Physiol. 267,C1682C1690.
  • 7
    Canessa C.M., Schild L., Buell G., Thorens B., Gautschi I., Horisberger J., Rossier B.C. (1994b) Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.Nature 367,463467.
  • 8
    Corey D.P. & Garcia-Anoveros J. (1996) Mechanosensation and the DEG/ENaC ion channels.Science 273,323324.
  • 9
    Coscoy S., Lingueglia E., Lazdunski M., Barbry P. (1998) The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer.J. Biol. Chem. 273,83178322.
  • 10
    De Léan A., Munson P.J., Rodbard D. (1978) Simultaneous analysis of families of sigmoidal curves : application to bioassay, radioligand assay, and physiological dose-response curves.Am. J. Physiol. 235,E97E102.
  • 11
    Dray A. & Perkins M. (1993) Bradykinin and inflammatory pain.Trends Neurosci. 16,99104.
  • 12
    Firsov D., Gautschi I., Merillat A., Rossier B.C., Schild L. (1998) The heterotetrameric architecture of the epithelial sodium channel (ENaC).EMBO J. 17,344352.
  • 13
    Garcia-Anoveros J., Derfler B., Neville-Golden J., Hyman B.T., Corey D.P. (1997) BNaCl and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.Proc. Natl. Acad. Sci. USA 94,14591464.
  • 14
    Ishibashi K. & Marumo F. (1998) Molecular cloning of a DEG/ENaC sodium channel from human testis.Biochem. Biophys. Res. Commun. 245,589593.DOI: 10.1006/bbrc.1998.8483
  • 15
    Kleyman T.R. & Cragoe E.J. (1988) Amiloride and its analogs as tools in the study of ion transport.J. Membr. Biol. 105,121.
  • 16
    Konnerth A., Lux H.D., Morad M. (1987) Proton-induced transformation of calcium channel in chick dorsal root ganglion cells.J. Physiol. (Lond.) 386,603633.
  • 17
    Krishtal O.A. & Pidoplichko V.I. (1981) A receptor for protons in the membrane of sensory neurons may participate in nociception.Neuroscience 6,25992601.
  •  
    Krishtal O.A., Osipchuk Y.V., Shelest T.N., and Smirnoff S.V. (1987) Rapid extracellular pH transients related to synaptic transmission in rat hippocampal slices.Brain Res. 436,352356.
  • 19
    Lennon G., Auffray C., Polymeropoulos M., Soares M.B. (1996) The I.M.A.G.E. consortium ; an integrated molecular analysis of genomes and their expression.Genomics 33,151152.
  • 20
    Lindahl O. (1974) Pain—a general chemical explanation. Adv. Neurol. 4,4547.
  • 21
    Lingueglia E., Champigny G., Lazdunski M., Barbry P. (1995) Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel.Nature 378,730733.
  • 22
    Lingueglia E., De Weille J.R., Bassilana F., Heurteaux C., Sakai H., Waldmann R., Lazdunski M. (1997) A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells.J. Biol. Chem. 272,2977829783.
  • 23
    North R.A. (1997) Families of ion channels with two hydrophobic segments.Curr. Opin. Cell Biol. 8,474483.
  • 24
    Price M.P., Snyder P.M., and Welsh M.J. (1996) Cloning and expression of a novel human brain Na+ channel.J. Biol. Chem. 271,78797882.
  • 25
    Snyder P.M., Cheng C., Prince L.S., Rogers J.C., Welsh M.J. (1998) Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits.J. Biol. Chem. 273,681684.
  • 26
    Tavernarakis N., Shreffler W., Wang S., Driscoll M. (1997) unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion.Neuron 18,107119.
  • 27
    Waldmann R., Champigny G., Voilley N., Lauritzen I., Lazdunski M. (1996) The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.J. Biol. Chem. 271,1043310436.
  • 28
    Waldmann R., Bassilana F., De Weille J., Champigny G., Heurteaux C., Lazdunski M. (1997a) Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.J. Biol. Chem. 272,2097520978.
  • 29
    Waldmann R., Champigny G., Bassilana F., Heurteaux C., Lazdunski M. (1997b) A proton-gated cation channel involved in acid-sensing.Nature 386,173177.