SEARCH

SEARCH BY CITATION

Acknowledgements

This study was supported by grant CA43047 from the National Institutes of Health (D.B.D.). David Schubert is thanked for the kind gift of HT22 cells. Geldanamycin was provided by the Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute.

  • 1
    Amin V., Cumming D.V.E., Latchman D.S. (1996) Overexpression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies.Neurosci. Lett.206,4548.
  • 2
    Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., Struhl K. (1994) Current Protocols in Molecular Biology. John Wiley, Boston.
  • 3
    Baiping L., Xiujuan T., Hongwei C., Qimig X., Quling G. (1994) Effect of moderate hypothermia on lipid peroxidation in canine brain after cardiac arrest and resuscitation.Stroke 25,147152.
  • 4
    Blagosklonny M.V., Schulte T., Nguyen P., Trepel J., Neckers L.M. (1996) Taxol-induced apoptosis and phosphorylation of bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.Cancer Res.56,18511854.
  • 5
    Chan P.H. (1996) Role of oxidants in ischemic brain damage.Stroke 27,11241129.
  • 6
    Choi D.W. (1990) Cerebral hypoxia : some new approaches and unanswered questions.J. Neurosci. 10,24932501.
  • 7
    Choi D.W. (1996) Ischemia-induced neuronal apoptosis.Curr. Opin. Neurobiol. 8,667672.
  • 8
    Conde A.G., Lau S.S., Dillmann W.H., Mestril R. (1997) Induction of heat shock proteins by tyrosine kinase inhibitors in rat cardiomyocytes and myogenic cells confers protection against simulated ischemia.J. Mol. Cell. Cardiol.26,19271938.
  • 9
    Coyle J.T. & Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders.Science 262,689695.
  • 10
    Davis J.B. & Maher P. (1994) Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line.Brain Res. 652,169173.
  • 11
    Hansen M.B., Nielsen S.E., Berg K. (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill.J. Immunol. Methods 119,203210.
  • 12
    Hedge R.S., Zuo J., Voellmy R., Welch W.J. (1995) Short circulating stress protein expression via a tyrosine kinase inhibitor, herbimycin A.J. Cell. Physiol. 165,186200.
  • 13
    Hosler B.A. & Brown R.H. (1996) Superoxide dismutase and oxygen radical neurotoxicity.Curr. Opin. Neurol. 9,486491.
  • 14
    Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., Ouml;rd T., Bredesen D.E. (1993) Bcl-2 inhibition of neural death : decreased generation of reactive oxygen species.Science 262,12741277.
  • 15
    Komara J.S., Nayani N.R., Bailick H.A., Indrieri R.I., Evans A.T., Garritano A.M., Jacobs W.A., Huang R.R., Krause G.S., White B.C., Aust S.D. (1986) Brain iron delocalization and lipid peroxidation following cardiac arrest.Ann. Emerg. Med. 15,384389.
  • 16
    Lazzarino G., Vagnozzi R., Tavazzi B., Pastore F.S., Di Pierro D., Siragusa P., Belli A., Giuffre R., Giardina B. (1992) MDA, oxypurines, and nucleosides relate to reperfusion in short-term incomplete cerebral ischemia in the rat.Free Radiac. Biol. Med. 13,489498.
  • 17
    Leist M. & Nicotera P. (1998) Apoptosis, excitotoxicity, and neuropathology.Exp. Cell Res. 239, 183201.
  • 18
    Li Y., Maher P., Schubert D. (1997a) Requirement for cGMP in nerve cell death caused by glutathione depletion.J. Cell Biol. 139,13171324.
  • 19
    Li Y., Maher P., Schubert D. (1997b) A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.Neuron 19,453463.
  • 20
    Liu P.K., Hsu C.Y., Dizdaroglu M., Floyd R.A., Kow Y.W., Karakaya A., Rabow L.E., Cui J.K. (1996) Damage, repair and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion.J. Neurosci. 16,67956806.
  • 21
    Lowenstein D.H., Chan P.H., Miles M.F. (1991) The stress protein response in cultured neurons : characterization and evidence for a protective role in excitotoxicity.Neuron 7,10531060.
  • 22
    Maher P. & Davis J.B. (1996) The role of monoamine metabolism in glutamate toxicity.J. Neurosci. 16,63946401.
  • 23
    Mailhos C., Howard M.K., Latchman D.S. (1993) Heat shock protects neuronal cells from programmed cell death by apoptosis.Neuroscience 55,621627.
  • 24
    Morimoto B.H. & Koshland D.E. (1989) Induction and expression of long-and short-term neurosecretory potentiation in a neural cell line.Neuron 5,875880.
  • 25
    Morimoto R.I. (1993) Cells in stress : transcriptional activation of heat shock genes.Science 259,14091410.
  • 26
    Morimoto R.I., Sarge K.D., Abravaya K. (1992) Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.J. Biol. Chem. 267,2198721990.
  • 27
    Mosmann T. (1983) Rapid colorimetric assay for cell growth and survival : application to proliferation and cytotoxicity assays.J. Immunol. Methods 65,5563.
  • 28
    Mosser D.D., Caron A.W., Bourget L., Denis-LaRose C., Massie B. (1997) Role of human heat shock protein hsp70 in protection against stress-induced apoptosis.Mol. Cell. Biol. 17,53175327.
  • 29
    Murakami Y., Uehara Y., Yamamoto C., Fukazawa H., Mizuno S. (1991) Induction of Hsp 72/73 by herbimycin A, an inhibitor of transformation by tyrosine kinase oncogenes.Exp. Cell Res. 195,338344.
  • 30
    Murphy T.H., Miyamoto M., Sastre A., Schnaar R.L., Coyle J.T. (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress.Neuron 2,15471558.
  • 31
    Murphy T.H., Schnaar R.L., Coyle J.T. (1990) Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake.FASEB J. 4,16241633.
  • 32
    Nair S.C., Toran E.J., Rimerman R.A., Hjermstad S., Smithgall T.E., Smith D.F. (1996) A pathway of multi-chaperone interactions common to diverse regulatory proteins : estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsfl, and the aryl hydrocarbon receptor.Cell Stress Chaperones 1,237250.
  • 33
    Polla B.S., Katengwa S., Francois D., Salvioli S., Franceschi C., Marsac C., Cossarizza A. (1996) Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.Proc. Natl. Acad. Sci. USA 93,64586463.
  • 34
    Pulsinelli W.A., Brierley J.B., Plum F. (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia.Ann. Neurol. 11,491498.
  • 35
    Sato K., Saito H., Matsuki N. (1996) HPS70 is essential to the neuroprotective effect of heat shock.Brain Res. 740,117123.
  • 36
    Schneider C., Sepp-Lorenzino L., Nimmesgern E., Ouerfelli O., Danishefsky S., Rosen N., Hartl F.U. (1996) Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.Proc. Natl. Acad. Sci. USA 93,1453614541.
  • 37
    Schreiber S.S. & Baudry M. (1995) Selective neuronal vulnerability in the hippocampus—a role for gene expression ? Trends Neurosci. 18,446451.
  • 38
    Schubert D., Kimura H., Maher P. (1992) Growth factors and vitamin E modify neuronal glutamate toxicity.Proc. Natl. Acad. Sci. USA 89,82648267.
  • 39
    Schulte T.W., Blagosklonny M.V., Ingui C., Neckers L. (1995) Disruption of the Raf-1-hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association.J. Biol. Chem. 270,2458524588.
  • 40
    Schulte T.W., Blagosklonny M.V., Romanova L., Mushinski J.F., Monia B.P., Johnston J.F., Nguyen P., Trepel J., Neckers L.M. (1996) Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.Mol. Cell. Biol. 16,58395845.
  • 41
    Simonian N.A. & Coyle J.T. (1996) Oxidative stress in neurodegenerative diseases.Annu. Rev. Pharmacol. Toxicol. 36,83106.
  • 42
    Supko J.G., Hickman R.L., Grever M.R., Malspeis L. (1995) Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent.Cancer Chemother. Pharmacol. 36,305315.
  • 43
    Tan S., Sagara Y., Liu Y., Maher P., Schubert D. (1998a) The regulation of reactive oxygen species production during programmed cell death.J. Cell Biol. 141,14231432.
  • 44
    Tan S., Wood M., Maher P. (1998b) Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells.J. Neurochem. 71,95105.
  • 45
    Verheij M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., Kolesnick R.N. (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Nature 380,7579.
  • 46
    Wang H., Rapp U.R., Reed J.C. (1996) Bcl-2 targets the protein kinase Raf-1 to mitochondria.Cell 87,629638.
  • 47
    Wei Y.Q., Zhao X., Kariya Y., Teshigawara K., Uchida A. (1995) Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells.Cancer Immunol. Immunother. 40,7378.
  • 48
    Whitesell L. & Cook P. (1996) Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.Mol. Endocrinol. 10,705712.
  • 49
    Whitesell L., Mimnaugh E.G., DeCosta B., Myers C.E., Neckers L.M. (1994) Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins : essential role for stress proteins in oncogenic transformation.Proc. Natl. Acad. Sci. USA 91,83248328.
  • 50
    Wu C. (1995) Heat shock transcription factors : structure and regulation.Annu. Rev. Cell Dev. Biol. 11,441469.
  • 51
    Yang J. & DeFranco D.B. (1994) Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.Mol. Cell. Biol. 14,50885098.