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Acknowledgements

We thank Dr. David Whittingham (MRC Experimental Embryology and Teratology Unit, St. George's Hospital Medical School, London, U.K.) for generously providing mice carrying the HPRT deletion mutation. We also thank Dr. Michael Kuehn (Experimental Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.) for providing mice carrying the retrovirus-mediated HPRT mutation. This study was supported by the Lesch-Nyhan Syndrome Children's Research Foundation (H.A.J., T.F., and G.R.B.) and NIH 1K08NS0198501 (H.A.J.).

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