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Acknowledgements

This study was funded by INSERM and a grant 222 European Neuroscience program. N. Bernoud was a recipient from M.E.S.R. (Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche). We gratefully acknowledge the assistance of Dr. I. Delton-Vandenbroucke for reading the manuscript.

  • 1
    Bénistant C., Achard F., Marcelon G., Lagarde M. (1993) Platelet inhibitory functions of aortic endothelial cells. Effects of eicosapentaenoic and docosahexaenoic acids.Atherosclerosis 104,2735.
  • 2
    Bénistant C., Dehouck M.P., Fruchart J., Cecchelli R., Lagarde M. (1995) Fatty acid composition of brain capillary endothelial cells : effect of the culture with astrocytes.J. Lipid Res. 36,23112319.
  • 3
    Bernhard W., Linck M., Creutzburg H., Postle A.D., Arning A., Martin-Carrera I. (1994) High-performance liquid chromatographic analysis of phospholipids from different sources with combined fluorescence and ultraviolet detection.Anal. Biochem. 220,172180.
  • 4
    Bligh E.G. & Dyer W.J. (1959) A rapid method of total lipid extraction and purification.Can. J. Biochem. Physiol. 37,911917.
  • 5
    Booher J. & Sensenbrenner M. (1972) Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask culture.Neurobiology 2,97105.
  • 6
    Borghini I., Barja F., Pometta D., James R.W. (1995) Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid.Biochim. Biophys. Acta 1255,192200.
  • 7
    Bourre J.M., Pascal G., Durand G., Masson M., Dumont O., Piciotti M. (1984) Alterations in the fatty acid composition of rat brain cells (neurons, astrocytes, and oligodendrocytes) and a subcellular fraction (myelin and synaptosomes) induced by diet devoid of n-3 fatty acids.J. Neurochem. 43,342348.
  • 8
    Brindley D.N. (1993) Hepatic secretion of lysophosphatidylcholine : a novel transport system for polyunsaturated fatty acids and choline.J. Nutr. Biochem. 4,442449.
  • 9
    Brossard N., Croset M., Normand S., Pousin J., Lecerf J., Laville M., Tayot J.L., Lagarde M. (1997) Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. J. Lipid Res. 38,15711582.
  • 10
    Crawford M.A., Casperd N.M., Sinclair A.J. (1976) The long chain metabolites of linoleic and linolenic acids in liver and brain in herbivores and carnivores.Comp. Biochem. Physiol. 54,395401.
  • 11
    Croset M., Brossard N., Pachiaudi C., Normand S., Lecerf J., Chirouze V., Riou J.P., Tayot J.L., Lagarde M. (1996) In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. Lipids 31,109115.
  • 12
    Dehouck M.P., Méresse S., Dehouck B., Fruchard J.C., Cecchelli R. (1992) In vitro reconstituted blood-brain barrier.J. Control Release 21,8192.
  • 13
    Fisher S.K. & Rowe C.E. (1980) The acylation of lysophosphatidylcholine by subcellular fractions of quinea-pig cerebral cortex.Biochim. Biophys. Acta 618,231241.
  • 14
    Folch J., Lees M., Sloane-Stanley S. (1957) A simple method for isolation and purification of total lipids from animal tissues.J. Biol. Chem. 226,497509.
  • 15
    Foldi M. (1996) The brain and the lymphatic system.Lymphology 29,19.
  • 16
    Fukagawa K., Knight D.S., Hamilton K.A., Tso P. (1995) Immunoreactivity for apolipoprotein A-IV in tanycytes and astrocytes of rat brain.Neurosci. Lett. 199,1720.
  • 17
    Gong J., Rosner B., Rees D.G., Berson E.L., Weigel-Difranco C.A., Schaefer E.F. (1992) Plasma docosahexaenoic acid levels in various genetic forms of retinitis pigmentosa.Invest. Ophthalmol. Vis. Sci. 33,25962602.
  • 18
    Graham G., Zammit V.A., Brindley D.N. (1988) Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes.Biochem. J. 249,722733.
  • 19
    Green P. & Yavin E. (1993) Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo.J. Lipid Res. 34,20992107.
  • 20
    Han S.H., Einstein G., Weisgraber K.H., Strittmatter W.J., Saunders A.M., Pericak-Vance M., Roses A.D., Schmeckel D.E. (1994) Apolipoprotein E is localized to the cytoplasm of human cortical neurons : a light and electron microscopy study.J. Neuropathol. Exp. Neurol. 53,535544.
  • 21
    Innis S.M. (1991) Essential fatty acids in growth and development.Prog. Lipid Res. 30,39103.
  • 22
    Klopfenstein W.E. (1969) Enthalpy change of binding lysolecithin to serum albumin.Biochim. Biophys. Acta 181,323325.
  • 23
    Knott G.W., Dziegielewska K.M., Hadgood M.D., Li Z.S., Saunders N.R. (1997) Albumin transfer across the choroid plexus of South American opossum (Monodelphis domestica).J. Physiol. (Lond.) 499,179194.
  • 24
    Koudinov A.R., Koudinova N.V., Kumar A., Beavis R.C., Ghiso J. (1996) Biochemical characterization of Alzeimer's soluble amyloid beta protein in human cerebrospinal fluid : association with high density lipoproteins.Biochem. Biophys. Res. Commun. 223,592597.DOI: 10.1006/bbrc.1996.0940
  • 25
    LaDu M.J., Gilligan S.M., Lukens J.R., Cabana V.G., Reardon C.A., Van Eldik L.J., Holtzman D.M. (1998) Nascent astrocyte particles differ from lipoproteins in CSF.J. Neurochem. 70,20702081.
  • 26
    Makrides M., Neumann M.A., Gibson R.A. (1996) Is dietary docosahexaenoic acid essential for term infants.Lipids 31,115119.
  • 27
    Mangiapane E.H. & Brindley D.N. (1986) Effects of dexamethasone and insulin on the synthesis of triacylglycerols and phosphatidylcholine and the secretion of very-low-density lipoproteins and lysophosphatidylcholine by monolayer cultures of rat hepatocytes.Biochem. J. 233,151160.
  • 28
    Méresse S., Dehouck M.P., Delorme P., Bensaïd M., Tauber J.P., Delbart C., Fruchart J.C., Cecchelli R. (1989) Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture.J. Neurochem. 53,13631371.
  • 29
    Moore S.A., Yoder E., Spector A.A. (1990) Role of the bloodbrain barrier in the formation of long-chain ω-3 and ω-6 fatty acids from essential fatty acid precursor. J. Neurochem. 55,391402.
  • 30
    Moore S.A., Yoder E., Murphy S., Dutton G.R., Spector A.A. (1991) Astrocytes, not neurons, produce docosahexaenoic acid (22 : 6ω-3) and arachidonic acid (20 : 4ω-6). J. Neurochem. 56,518524.
  • 31
    Morash S.C., Cook H.W., Spence M.W. (1989) Lysophosphatidylcholine as an intermediate in phosphatidylcholine metabolism and glycerophosphocholine synthesis in cultured cells : an evaluation of the roles of 1-acyl- and 2-acyl-lysophosphatidylcholine.Biochim. Biophys. Acta 1004,221229.
  • 32
    Mouchel Y., Lefrancois T., Fages C., Tardy M. (1995) Apolipoprotein E gene expression in astrocytes : developmental pattern and regulation.Neuroreport 7,205208.
  • 33
    Neuringer M., Connor W.E., Lin D.S., Barstad L., Luck S. (1986) Biochemical and functional effects of prenatal and postnatal w-3 fatty acid deficiency on retina and brain in rhesus monkeys.Proc. Natl. Acad. Sci. USA 83,40214025.
  • 34
    Neuringer M., Anderson G.J., Connor W.E. (1988) The essentiality of n-3 fatty acids for the development and function of the retina and brain.Annu. Rev. Nutr. 8,517541.
  • 35
    Pardridge W.M. (1991) Overview of BBB transport biology and experimental methodologies, inPeptide Drug Delivery to the Brain (Pardridge W. M., ed), pp. 99122. Raven Press, New York.
  • 36
    Patel S.C., Asotra K., Patel Y.C., McConathy W.J., Patel R.C., Suresh S. (1995) Astrocytes synthesize and secrete the lipophilic ligand carrier apolipoprotein D.Neuroreport 6,653657.
  • 37
    Pawloski R.J., Ward G., Salem N.J r. (1996) Essential fatty acid uptake and metabolism in the developing rodent brain.Lipids 31,103107.
  • 38
    Pitas R.E., Boyles J.K., Lee S.H., Foss D., Mahley R.W. (1987a) Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins.Biochim. Biophys. Acta 917,148161.
  • 39
    Pitas R.E., Boyles J.K., Lee S.H., Hui D., Weisgraber K.H. (1987b) Lipoproteins and their receptors in the cerebral nervous system. Characterization of the lipoprotein in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain.J. Biol. Chem. 262,1435214360.
  • 40
    Plateel M., Teissier E., Cecchelli R. (1997) Hypoxia dramatically increases the nonspecific transport of blood-borne proteins to the brain.J. Neurochem. 68,874877.
  • 41
    Salem N.J, Kim H.Y., Yergey J.A. (1986) Docosahexaenoic acid membrane function and metabolism, inHealth Effects of Polyunsaturated Fatty Acid in Seafoods (Simopoulos A. P., Kifer R. R., and Martin R., eds), pp. 263317. Academic Press, Orlando.
  • 42
    Scott B.L. & Bazan N.G. (1989) Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.Proc. Natl. Acad. Sci. USA 86,29032907.
  • 43
    Subbaiah P.V., Liu M., Paltauf F. (1994) Role of sn-2 acyl group of phosphatidylcholine in determining the positional specificity of lecithin-cholesterol acyltransferase.Biochemistry 33,1325913266.
  • 44
    Thiès F., Delachambre M.C., Bentejac M., Lagarde M., Lecerf J. (1992) Unsaturated fatty acids esterified in 2-acyl-1-lysophosphatidylcholine bound to albumin are more efficiently taken up by the young rat brain than the unesterified from.J. Neurochem. 59,11101116.
  • 45
    Thiès F., Pillon C., Molière P., Lagarde M., Lecerf J. (1994) Preferential incroporation of sn-2 lysoPC-DHA over unesterified DHA in the young rat brain.Am. J. Physiol. 267,R1273R1279.
  • 46
    Wainwright P.E., Huang Y.S., Bulman-Fleming B., Mills D.E., Redden P., McCutcheon D. (1991) The role of n-3 essential fatty acids in brain and behavioural development : a cross-fostering study in the mouse.Lipids 26,3745.
  • 47
    Wells J.M., Amaratunga A., McKenna D.C., Abraham C.R., Fine R.E. (1995) Amyloid beta-protein precursor and apolipoprotein E production in cultured cerebral endothelial cells isolated from brain of patients with neurodegenerative disorders at autopsy.Amyloid Int. J. Exp. Clin. Invest. 2,229233.
  • 48
    Werkman S.H. & Carlson E. (1996) A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months.Lipids 31,9197.
  • 49
    Wong J.T., Trang K., Pierce G.N., Chan A.C., Karmin O., Choy P.C. (1998) Lysophosphatidylcholine stimulates the release of arachidonic acid in human endothelial cells.J. Biol. Chem. 273,68306836.
  • 50
    Yamamoto N., Saitoh M., Moriuchi A., Nomura M., Okuyama H. (1987) Effect of dietary α-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. J. Lipid Res. 28,144151.