SEARCH

SEARCH BY CITATION

Acknowledgements

This study was supported by National Institutes of Health grants NS33958 (J.D.R.), AG12992 (J.D.R.), and GM50016 (V.C.C.), along with support from the Muscular Dystrophy Association (J.D.R.) and the ALS Association (J.D.R. and V.C.C.).

  • 1
    Bensimon G., Lacomblez L., Meininger V., Riluzole Study G roup (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis.N. Engl. J. Med. 330,585591.
  • 2
    Blackstone C.D., Levey A.I., Martin L.J., Price D.L., Huganir R.L. (1992) Immunological detection of glutamate receptor subtypes in human central nervous system.Ann. Neurol. 31,680683.
  • 3
    Borchelt D.R., Lee M.K., Slunt H.H., Guarnieri M., Xu Z., Wong P.C., Brown R.H.J, Price D.L., Sisodia S.S., Cleveland D.W. (1994) Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.Proc. Natl. Acad. Sci. USA 91,82928296.
  • 4
    Bruijn L.I., Becher M.W., Lee M.K., Anderson K.L., Jenkins N.A., Copeland N.G., Sisodia S.S., Rothstein J.D., Borchelt D.R., Price D.L., Cleveland D.W. (1997) ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.Neuron 18,327338.
  • 5
    Corson L.B., Strain J.J., Culotta V.C., Cleveland D.W. (1998) Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants.Proc. Natl. Acad. Sci. USA 95,63616366.
  • 6
    Culotta V.C., Klomp L.W.J., Strain J., Casareno R.L.B., Krems B., Gitlin J.D. (1997) The copper chaperone for superoxide dismutase.J. Biol. Chem. 272,2346923472.
  • 7
    Fridovich I. (1986) Superoxide dismutases.Adv. Enzymol. Relat. Areas Mol. Biol. 58,6197.
  • 8
    Glerum D.M., Shtanko A., Tzagoloff A. (1996a) SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae.J. Biol. Chem. 271,2053120535.
  • 9
    Glerum D.M., Shtanko A., Tzagoloff A. (1996b) Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.J. Biol. Chem. 271,1450414509.
  • 10
    Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H., Chen W., Zhai P., Sufit R.L., Siddique T. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.Science 264,17721775.
  • 11
    Harris Z.L. & Gitlin J.D. (1996) Genetic and molecular basis for copper toxicity.Am. J. Clin. Nutr. 63,836S841S.
  • 12
    Klomp L.W.J., Lin S., Yuan D.S., Klausner R.D., Culotta V.C., Gitlin J.D. (1997) Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis.J. Biol. Chem. 272,92219226.
  • 13
    Kuncl R.W., Crawford T.O., Rothstein J.D., Drachman D.B. (1992) Motor neuron diseases, inDiseases of the Nervous System (Asbury A. K., McKhann G. M., and McDonald W. I., eds), pp. 11791208. W. B. Saunders, Philadelphia.
  • 14
    Lacomblez L., Bensimon G., Leigh P.N., Guillet P., Meininger V. (1996) Dose-ranging study of riluzole in amyotrophic lateral sclerosis.Lancet 347,14251431.
  • 15
    Lin S. & Culotta V.C. (1995) The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity.Proc. Natl. Acad. Sci. USA 92,37843788.
  • 16
    Miller R.G., Gelinas D., Moore D., Mendoza M., Quien A., Young L., Armon C., Linda L., Barohn R., Bryan W., Bromberg M., Petajan J., Neville H., Ringel S., Parry G., Ravits J., Ross M., Leiderman D. (1996) A placebo-controlled trial of gabapentin in amyotrophic lateral sclerosis.Neurology 46,A469.
  • 17
    Pardo C.A., Xu Z., Borchelt D.R., Price D.L., Sisodia S.S., Cleveland D.W. (1995) Superoxide dismutase is an abundant component in cell bodies, dendrites,and axons of motor neurons and in a subset of other neurons.Proc. Natl. Acad. Sci. USA 92,954958.
  • 18
    Pufahl R.A., Singer C.P., Peariso K.L., Lin S., Schmidt P.J., Fahrni C.J., Culotta V.C., Penner-Hahn J.E., O'Halloran T.V. (1997) Metal ion chaperone function of the soluble Cu(I) receptor Atx1.Science 278,853856.
  • 19
    Ripps M.E., Huntley G.W., Hof P.R., Morrison J.H., Gordon J.W. (1995) Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.Proc. Natl. Acad. Sci. USA 92,689693.
  • 20
    Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., Nash N., Kuncl R.W. (1994) Localization of neuronal and glial glutamate transporters.Neuron 13,713725.
  • 21
    Rowland L.P. (1994) Natural history and clinical features of amyotrophic lateral sclerosis and related motor neuron diseases, inNeurodegenerative Diseases (Calne D. B., ed), pp. 507521. W. B. Saunders, Philadelphia.
  • 22
    Siddique T. & Deng H.X. (1996) Genetics of amyotrophic lateral sclerosis.Hum. Mol. Genet. 5,14651470.
  • 23
    Solomon E.I. & Lowery M.D. (1993) Electronic structure contributions to function in bioinorganic chemistry.Science 259,15751581.
  • 24
    Valentine J.S. & Gralla E.B. (1997) Delivering copper inside yeast and humans.Science 278,817818.DOI: 10.1126/science.278.5339.817
  • 25
    Wong P.C., Pardo C.A., Borchelt D.R., Lee M.K., Copeland N.G., Jenkins N.A., Sisodia S.S., Cleveland D.W., Price D.L. (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria.Neuron 14,11051116.