• 1
    Banker G., Churchill L. & Cotman C.W. (1974) Proteins of the postsynaptic density.J. Cell Biol. 63,456465.
  • 2
    Baudry M., Bundman M.C., Smith E.K. & Lynch G. (1981) Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes.Science 212,937938.
  • 3
    Belmont L.D. & Mitchison T.J. (1996) Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.Cell 84,623631.
  • 4
    Belmont L., Mitchison T. & Deacon H.W. (1996) Catastrophic revelations about Op18/stathmin.Trends Biochem. Sci. 21,197198.
  • 5
    Berkowitz S.A. & Wolff J. (1981) Intrinsic calcium sensitivity of tubulin polymerization : the contributions of temperature, tubulin concentration, and associated proteins.J. Biol. Chem. 256,1121611223.
  • 6
    Bernhardt R. & Matus A. (1984) Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain : a difference between dendritic and axonal cytoskeletons.J. Comp. Neurol. 226,203221.
  • 7
    Bernier-Valentin F., Aunis D. & Rousset B. (1983) Evidence for tubulin-binding sites on cellular membranes, plasma membranes, mitochondrial membranes, and secretory granule membranes.J. Cell Biol. 97,209216.
  • 8
    Bhattacharyya B. & Wolff J. (1975) Membrane-bound tubulin in brain and thyroid tissue.J. Biol. Chem. 250,76397646.
  • 9
    Bigot D. & Hunt S.P. (1990) Effect of excitatory amino acids on microtubule-associated proteins in cultured cortical and spinal neurones.Neurosci. Lett. 111,275280.
  • 10
    Bigot D. & Hunt S.P. (1991) The effects of quisqualate and nocodazole on the organization of MAP2 and neurofilaments in spinal cord neurons in vitro.Neurosci. Lett. 131,2126.
  • 11
    Bigot D., Matus A. & Hunt S.P. (1991) Reorganization of the cytoskeleton in rat neurons following stimulation with excitatory amino acids in vitro.Eur. J. Neurosci. 3,551558.
  • 12
    Brakeman P.R., Lanahan A.A., O'Brien R., Roche K., Barnes C.A., Huganir R.L. & Worley P.F. (1997) Homer : a protein that selectively binds metabotropic glutamate receptors.Nature 386,284288.
  • 13
    Brenman J., Chao D.S., Gee S.H., McGee A.W., Craven S.E., Santillano D.R., Wu Z., Huang F., Xia H., Peters M.F., Froehner S.C. & Bredt D.S. (1996 a) Interaction of nitric oxide synthase with the postsynaptic density protein psd-95 and alpha 1-syntrophin mediated by pdz domains. Cell 84,757767.
  • 14
    Brenman J.E., Christopherson K.S., Craven S.E., McGee A.W. & Bredt D.S. (1996 b) Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. J. Neurosci. 16,74077415.
  • 15
    Brugg B. & Matus A. (1991) Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.J. Cell Biol. 114,735743.
  • 16
    Chen C. & Tonegawa S. (1997) Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain.Annu. Rev. Neurosci. 20,157184.
  • 17
    Chicurel M.E. & Harris K.M. (1992) Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus.J. Comp. Neurol. 325,169182.
  • 18
    Cho K.O., Hunt C.A. & Kennedy M.B. (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.Neuron 9,929942.
  • 19
    Dong H., O'Brien R.J., Fung E.T., Lanahan A.A., Worley P.F. & Huganir R.L. (1997) GRIP : a synaptic PDZ domain-containing protein that interacts with AMPA receptors.Nature 386,279284.
  • 20
    Edson K., Weisshaar B. & Matus A. (1993) Actin depolymerisation induces process formation on MAP2-transfected non-neuronal cells.Development 117,689700.
  • 21
    Ehlers M.D., Tingley W.G. & Huganir R.L. (1995) Regulated subcellular distribution of the NR1 subunit of the NMDA receptor.Science 269,17341737.
  • 22
    Ehlers M.D., Zhang S., Bernhadt J.P. & Huganir R.L. (1996) Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit.Cell 84,745755.
  • 23
    Fanning A.S. & Anderson J.M. (1996) Protein-protein interactions : PDZ domain networks.Curr. Biol. 6,13851388.
  • 24
    Fifkova E. & Van Harreveld A. (1977) Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal area.J. Neurocytol. 6,211230.
  • 25
    Fujiwara T., Yamamori T., Yamaguchi K. & Akagawa K. (1997) Interaction of hpc-1/syntaxin 1a with the cytoskeletal protein, tubulin.Biochem. Biophys. Res. Commun. 231,352355.
  • 26
    Gray E.G., Westrum L.E., Burgoyne R.D. & Barron J. (1982) Synaptic organisation and neuron microtubule distribution.Cell Tissue Res. 226,579588.
  • 27
    Gulley R.L. & Reese T.S. (1981) Cytoskeletal organization at the postsynaptic complex.J. Cell Biol. 91,298302.
  • 28
    Halpain S. & Greengard P. (1990) Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2.Neuron 5,237246.
  • 29
    Harris K.M. & Kater S.B. (1994) Dendritic spines : cellular specializations imparting both stability and flexibility to synaptic function.Annu. Rev. Neurosci. 17,341371.
  • 30
    Hata Y., Butz S. & Sudhof T.C. (1996) Cask : a novel dlg/psd95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.J. Neurosci. 16,24882494.
  • 31
    Hatta S., Ozawa H., Saito T. & Ohshika H. (1995) Participation of tubulin in the stimulatory regulation of adenylyl cyclase in rat cerebral cortex membranes.J. Neurochem. 64,13431350.
  • 32
    Hernandez M.A., Wandosell F. & Avila J. (1987) Localization of the phosphorylation sites for different kinases in the microtubule-associated protein MAP2.J. Neurochem. 48,8493.
  • 33
    Illenberger S., Drewes G., Trinczek B., Biernat J., Meyer H.E., Olmsted J.B., Mandelkow E.M. & Mandelkow E. (1996) Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark : phosphorylation sites and regulation of microtubule dynamics.J. Biol. Chem. 271,1083410843.
  • 34
    Job D., Pabion M. & Margolis R.L. (1985) Generation of microtubule stability subclasses by microtubule-associated proteins : implications for the microtubule “dynamic instability” model.J. Cell Biol. 101,16801689.
  • 35
    Kaech S., Ludin B. & Matus A. (1996) Cytoskeletal plasticity in cells expressing neuronal microtubule-associated proteins.Neuron 17,11891199.
  • 36
    Keith C., DiPaola M., Maxfield F.R. & Shelanski M.L. (1983) Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules. J. Cell Biol. 97,19181924.
  • 37
    Kelly P.T. & Cotman C.W. (1978) Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide.J. Cell Biol. 79,173183.
  • 38
    Kennedy M.B. (1993) The postsynaptic density.Curr. Opin. Neurobiol. 3,732737.
  • 39
    Kim E., Niethammer M., Rothschild A., Jan Y.N. & Sheng M. (1995) Clustering of shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.Nature 378,8588.
  • 40
    Kim E., Cho K.O., Rothschild A. & Sheng M. (1996) Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins.Neuron 17,103113.
  • 41
    Kornau H.C., Schenker L.T., Kennedy M.B. & Seeburg P.H. (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.Science 269,17371740.
  • 42
    Kotani S., Nishida E., Kumagai H. & Sakai H. (1985) Calmodulin inhibits interaction of actin with MAP2 and tau, two major microtubule-associated proteins.J. Biol. Chem. 260,1077910783.
  • 43
    Lau L.F., Mammen A., Ehlers M.D., Kindler S., Chung W.J., Garner C.C. & Huganir R.L. (1996) Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. J. Biol. Chem. 271,2162221628.
  • 44
    Lee Y.C. & Wolff J. (1984) Calmodulin binds to both microtubule-associated protein 2 and τ proteins.J. Biol. Chem. 259,12261230.
  • 45
    Legendre P., Rosenmund C. & Westbrook G.L. (1993) Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium.J. Neurosci. 13,674684.
  • 46
    Mattson M.P. & Kater S.B. (1989) Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture.Brain Res. 478,337348.
  • 47
    Matus A.I. & Jones-Taff D.H. (1978) Morphology and molecular composition of isolated postsynaptic junctional structures.Proc. R. Soc. Lond. 203,135151.
  • 48
    Morales M. & Fifkova E. (1989) Distribution of MAP2 in dendritic spines and its colocalization with actin.Cell Tissue Res. 256,447456.
  • 49
    Muller B.M., Kistner U., Veh R.W., Cases-Langhoff C., Becker B., Gundelfinger E.D. & Garner C.C. (1995) Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein.J. Neurosci. 15,23542366.
  • 50
    Muller B.M., Kistner U., Kindler S., Chung W.J., Kuhlendahl S., Fenster S.D., Lau L.F., Veh R.W., Huganir R.L., Gundelfinger E.D. & Garner C.C. (1996) SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexesin vivo. Neuron 17,255265.
  • 51
    Paschal B., Obar R.A. & Vallee R.B. (1989) Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin.Nature 342,569572.
  • 52
    Pedrotti B., Colombo R. & Islam K. (1994) Interactions of microtubule-associated protein MAP2 with unpolymerized and polymerized tubulin and actin using a 96-well microtiter plate solid-phase immunoassay.Biochemistry 33,87988806.
  • 53
    Popova J.S., Garrison J.C., Rhee S.G. & Rasenick M.M. (1997) Tubulin, Gq, and phosphatidylinositol 4,5-bisphosphate interact to regulate phospholipase Cb1 signaling.J. Biol. Chem. 272,67606765.
  • 54
    Quinlan E.M. & Halpain S. (1996) Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors.Neuron 16,357368.
  • 55
    Rasenick M.M. & Wang N. (1988) Exchange of guanine nucleotides between tubulin and GTP-binding proteins that regulate adenylate cyclase : cytoskeletal modification of neuronal signal transduction.J. Neurochem. 51,300311.
  • 56
    Rashid N.A. & Cambray-Deakin M.A. (1992) N-Methyl-D-aspartate effects on the growth, morphology and cytoskeleton of individual neurons in vitro. Dev. Brain Res. 67,301308.
  • 57
    Riederer B.M., Pellier V., Antonsson B., Di Paolo G., Stimpson S.A., Lutjens R., Catsicas S. & Grenningloh G. (1997) Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10.Proc. Natl. Acad. Sci. USA 94,741745.
  • 58
    Rosenmund C. & Westbrook G.L. (1993 a) Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 10,805814.
  • 59
    Rosenmund C. & Westbrook G.L. (1993 b) Rundown of N-methyl-D-aspartate channels during whole-cell recording in rat hippocampal neurons : role of Ca2+ and ATP.J. Physiol. (Lond.) 470,705729.
  • 60
    Saras J. & Heldin C. -H. (1996) PDZ domains bind carboxy-terminal sequences of target proteins.Trends Biochem. Sci. 21,455458.
  • 61
    Sheng M. (1996) PDZs and receptor/channel clustering : rounding up the latest suspects.Neuron 17,575578.
  • 62
    Siman R. & Noszek J.C. (1988) Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo.Neuron 1,279287.
  • 63
    Sobel A., Boutterin M., Beretta L., Chneiweiss H., Doye V. & Peyro-Saint-Paul H. (1989) Intracellular substrates for extracellular signaling : characterization of a ubiquitous, neuron-enriched phosphoprotein (stathmin).J. Biol. Chem. 264,37653772.
  • 64
    Stein R., Mori N., Matthews K., Lo L.C. & Anderson D.J. (1988) The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons.Neuron 1,463476.
  • 65
    Stephens R.E. (1986) Membrane tubulin.Biol. Cell 57,95110.
  • 66
    Therein H.M. & Mushynski W.E. (1976) Isolation of synaptic junctional complexes of high structural integrity from rat brain.J. Cell Biol. 71,807822.
  • 67
    Tsunoda S., Sierralta J., Sun Y., Bodner R., Suzuki E., Becker A., Socolich M. & Zuker C.S. (1997) A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.Nature 388,243249.
  • 68
    Vallée R.B. (1986) Reversible assembly purification of microtubules without assembly-promoting agents and further purification of tubulin, microtubule-associated proteins, and map fragments.Methods Enzymol. 134,89104.
  • 69
    Van Rossam D. (1998) Modulation of the cytoskeletal architecture by calcium, in Integrative Aspects of Calcium Signalling (Verkhratsky A. and Toescu E., eds), pp. 177196. Plenum Press, New York.
  • 70
    Walsh M.J. & Kuruc N. (1992) The postsynaptic density : constituent and associated proteins characterized by electrophoresis, immunoblotting, and peptide sequencing.J. Neurochem.59,667678.
  • 71
    Walters B.B. & Matus A.I. (1975) Tubulin in postsynaptic junctional lattice.Nature 257,496498.
  • 72
    Wang N., Yan K. & Rasenick M.M. (1990) Tubulin binds specifically to the signal-transducing proteins, Gsa and Gial.J. Biol. Chem. 265,12391242.
  • 73
    Weisenberg R.C. (1972) Microtubule formation in vitro in solutions containing low calcium concentrations.Science 177,11041105.
  • 74
    Westrum L.E., Jones D.H., Gray E.G. & Barron J. (1980) Microtubules, dendritic spines and spine apparatuses.Cell Tissue Res. 208,171181.
  • 75
    Wyszynski M., Lin J., Rao A., Nigh E., Beggs A.H., Craig A.M. & Sheng M. (1997) Competitive binding of α-actinin and calmodulin to the NMDA receptor. Nature 385,439442.
  • 76
    Yan K., Greene E., Belga F. & Rasenick M.M. (1996) Synaptic membrane G proteins are complexed with tubulin in situ.J. Neurochem. 66,14891495.