This work was supported by CONICET and the University of Buenos Aires (Argentina) and Pronex (Brazil).

  • 1
    Antkiewicz-Michaluk L., Guidotti A., Krueger K.E. (1988) Molecular characterization and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands.Mol. Pharmacol.34 272278.
  • 2
    Bernabeu R., Bevilaqua L., Ardenghi P., Bromberg E., Schmitz P., Bianchin M., Izquierdo I., Medina J.H. (1997) Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats.Proc. Natl. Acad. Sci. USA 94 70417046.
  • 3
    Bito H., Deisseroth K., Tsien R.W. (1996) CREB phosphorylation and dephosphorylation: a Ca2+ - and stimulus duration-dependent switch for hippocampal gene expression.Cell 87 12031214.
  • 4
    Bourtchuladze R., Frenguelli B., Blendy J., Schutz G., Silva A. (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element binding protein.Cell 79 5968.
  • 5
    Crino P., Khodakhah K., Becker K., Ginsberg S., Hemby S., Eberwine J. (1998) Presence and phosphorylation of transcription factors in developing dendrites.Proc. Natl. Acad. Sci. USA 95 23132318.
  • 6
    Deisseroth K., Bito H., Tsien R.W. (1996) Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity.Neuron 16 89101.
  • 7
    Deisseroth K., Heist E.K., Tsien R.W. (1998) Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons.Nature 392 198202.
  • 8
    De Robertis E., Pellegrino de Iraldi A., Rodriguez de Lores Arnaiz G., Salganicoff L. (1962) Cholinergic and non-cholinergic nerve endings in rat brain: I. Isolation and subcellular distribution of acetylcholinesterase.J. Neurochem.9 2325.
  • 9
    Ghosh A. & Greenberg M.E. (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences.Science 268 239247.
  • 10
    Ginty D.D., Kornhauser J.M., Thompson M.A., Bading H., Mayo K.E., Takahashi J.S., Greenberg M.E. (1993) Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.Science 260 238241.
  • 11
    Guerra F.C. (1974) Rapid isolation technique for mitochondria: technique for rat liver mitochondria.Methods Enzymol.31 299305.
  • 12
    Gusowski J.F. & McGaugh J.L. (1997) Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training.Proc. Natl. Acad. Sci. USA 94 26932698.
  • 13
    Kornhauser J.M., Nelson D.E., Mayo K.E., Takahashi J.S. (1992) Regulation of jun-b messenger RNA and AP-1 activity by light and a circadian clock.Science 255 15811584.
  • 14
    Lai J.C.K. & Clark J.B. (1979) Preparation of synaptic and nonsynaptic mitochondria from mammalian brain.Methods Enzymol.55 5160.
  • 15
    Liu X. & Jones E.G. (1996) Localization of alpha type II calcium calmodulin-dependent protein kinase at glutamatergic but not aminobutyric acid (GABAergic) synapses in thalamus and cerebral cortex.Proc. Natl. Acad. Sci. USA 93 73327336.
  • 16
    Meberg P.J., Kinney W.R., Valcourt E.G., Routtenberg A. (1996) Gene expression of the transcription factor NFκB in hippocampus: regulation by synaptic activity: Mol. Brain Res.38 179190.
  • 17
    Miller R.J. (1998) Mitochondria—the Kraken wakes! Trends Neurosci.21 9597.
  • 18
    Montminy M. (1997) Transcriptional regulation by cyclic AMP.Annu. Rev. Biochem.66 807822.
  • 19
    O'Neill L.A.J. & Kaltschmidt C. (1997) NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci.20 252257.
  • 20
    Suzuki T., Mitake S., Okumura-Noji K., Yang J., Fujii T., Okamoto T. (1997) Presence of NF-κB-like and IκB-like immunoreactivity in postsynaptic densities. Neuroreport 8 29312935.
  • 21
    Tang Y.G. & Zucker R.S. (1997) Mitochondrial involvement in post-tetanic potentiation of synaptic transmission.Neuron 18 483491.
  • 22
    Towbin H., Staehelin T., Gordon J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proc. Natl. Acad. Sci. USA 76 43504354.
  • 23
    Yin J.C.P., Wallach J.S., Del Vecchio M., Wilder E.L., Quinn W.G., Tully T. (1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79 4958.