• 1
    Arias J., Alberts A.S., Brindle P., Claret F.X., Smeal T., Karin M., Feramisco J., Montminy M. (1994) Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370 226229.
  • 2
    Bito H., Deisseroth K., Tsien R.W. (1996) CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration-dependent switch for hippocampal gene expression. Cell 87 12031214.
  • 3
    Borsook D., Konradi C., Falkowski O., Comb M., Hyman S.E. (1994) Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol. Endocrinol. 8 240248.
  • 4
    Brindle P., Nakajima T., Montminy M. (1995) Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. Proc. Natl. Acad. Sci. USA 92 1052110525.
  • 5
    Brown M.T. & Cooper J.A. (1996) Regulation, substrates and functions of src. Biochim. Biophys. Acta 1287 121149.
  • 6
    Bushman W.A., Wilson L.K., Luttrell D.K., Moyers J.S., Parsons S.J. (1990) Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation. Proc. Natl. Acad. Sci. USA 87 74627466.
  • 7
    Calleja V., Enriquez P.R., Filloux C., Peraldi P., Baron V., Obberghen E.V. (1997) The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor. Endocrinology 138 11111120.
  • 8
    Campbell G.S., Yu C., Jove R., Carter-Su C. (1997) Constitutive activation of JAK1 in src-transformed cells. J. Biol. Chem. 272 25912594.
  • 9
    Chackalaparampil I., Bagrodia S., Shalloway D. (1994) Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor. Oncogene 9 19471955.
  • 10
    Chen Y.H., Pouyssegur J., Courtneidge S.A., Van Obberghen-Schilling E. (1994) Activation of the Src family kinase activity by the G-protein coupled thrombin receptor in growth-responsive fibroblasts. J. Biol. Chem. 269 2737227377.
  • 11
    Chu H., Tan Y., Kobierski L.A., Balsam L.B., Comb M.J. (1994) Activating transcription factor-3 stimulates 3′, 5′-cyclic adenosine monophosphate-dependent gene expression. Mol. Endocrinol. 8 5968.
  • 12
    Cole R.L., Konradi C., Douglass J., Hyman S.E. (1995) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14 813823.
  • 13
    Comb M., Birnberg N.C., Seasholtz A., Herbert E., Goodman H.M. (1986) A cyclic AMP- and phorbol ester-inducible DNA element. Nature 323 353356.
  • 14
    Comb M., Mermod N., Hyman S.E., Pearlberg J., Ross M.E., Goodman H.M. (1988) Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J. 7 37933805.
  • 15
    Cook S.J. & McCormick F. (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262 10691072.
  • 16
    Devary Y., Gottleib R.A., Smeal T., Karin M. (1992) The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71 10811091.
  • 17
    Diverse-Pierluissi M., Remmers A.E., Neubig R.R., Dunlap K. (1997) Novel form of crosstalk between G protein and tyrosine kinase pathways. Proc. Natl. Acad. Sci. USA 94 54175421.
  • 18
    Faure M., Voyno-Yasenetskaya T.A., Bourne H.R. (1994) cAMP and bg subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem. 269 78517854.
  • 19
    Ferrari K., Gill G., Montminy M. (1994) The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. Proc. Natl. Acad. Sci. USA 91 12101213.
  • 20
    Frodin M., Peraldi P., Van Obberghen E. (1994) Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J. Biol. Chem. 269 62076214.
  • 21
    Fukazawa H., Li P., Yamamoto C., Murakami Y., Mizuno S., Uehara Y. (1991) Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin a in vitro. Biochem. Pharmacol. 42 16611671.
  • 22
    Giulian D., Vaca K., Corpuz M. (1993) Brain glia release factors with opposing actions upon neuronal survival. J. Neurosci. 13 2937.
  • 23
    Gonzalez G.A. & Montminy M.R. (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59 675680.
  • 24
    Graves L.M., Bornfield K.E., Raines E.W., Potts B.C., Macdonald S.G., Ross R., Krebs E.G. (1993) Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc. Natl. Acad. Sci. USA 90 1030010304.
  • 25
    Hausdorff W.P., Pitcher J.A., Luttrell D.K., Linder M.E., Kurose H., Parsons S.J., Caron M.G., Lefkowitz R.J. (1992) Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. Proc. Natl. Acad. Sci. USA 89 57205724.
  • 26
    Hyman S.E., Comb M., Pearlberg J., Goodman H.M. (1989) An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Mol. Cell. Biol. 9 321324.
  • 27
    Johnson P.J., Coussens P.M., Danko A.V., Shalloway D. (1985) Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells. Mol. Cell. Biol. 5 10731083.
  • 28
    Kee B.L., Arias J., Montminy M.R. (1996) Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J. Biol. Chem. 271 23732375.
  • 29
    Kobierski L.A., Chu H., Tan Y., Comb M.J. (1991) cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins. Proc. Natl. Acad. Sci. USA 88 1022210226.
  • 30
    Konradi C., Kobierski L.A., Nguyen T.V., Heckers S., Hyman S.E. (1993) The cAMP-response-element-binding protein interacts, but Fos protein does not interact with the proenkephalin enhancer in rat striatum. Proc. Natl. Acad. Sci. USA 90 70057009.
  • 31
    Konradi C., Cole R.L., Heckers S., Hyman S.E. (1994) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J. Neurosci. 14 56235634.
  • 32
    Konradi C., Cole R.L., Green D., Senatus P., Leveque J., Pollack A.E., Grossbard S.J., Hyman S.E. (1995) Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. J. Neurochem. 65 10071015.
  • 33
    Kwok R.P.S., Lundblad J.R., Chrivia J.C., Richards J.P., Bächinger H.P., Brennan R.G., Roberts S.G.E., Green M.R., Goodman R.H. (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370 223226.
  • 34
    Lee C., Yun Y., Hoeffler J.P., Habener J.F. (1990) Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J. 9 44554465.
  • 35
    Melner M.H., Low K.G., Allen R.G., Nielsen C.P., Young S.L., Saneto R.P. (1990) The regulation of proenkephalin expression in a distinct population of glial cells. EMBO J. 9 791796.
  • 36
    Moarefi I., LaFevre-Bernt M., Sicheri F., Huse M., Lee C., Kuriyan J., Miller W.T. (1997) Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385 650653.
  • 37
    Moyers J.S., Bouton A.H., Parsons S.J. (1993) The sites of phosphorylation of protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src. Mol. Cell. Biol. 13 23912400.
  • 38
    Mukhopadhyay D., Tsiokas L., Zhou X., Foster D., Brugge J.S., Sukhatme V.P. (1995) Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature 375 577581.
  • 39
    Nguyen T.V., Kobierski L.A., Comb M., Hyman S.E. (1990) The effect of depolarization on expression of the human proenkephalin gene is synergistic with cAMP and dependent upon a cAMP-inducible enhancer. J. Neurosci. 10 28252833.
  • 40
    Ralston R. & Bishop J.M. (1985) The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 82 78457849.
  • 41
    Roth C.W., Richert N.D., Pastan I., Gottesman M.M. (1983) Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src kinase activity. J. Biol. Chem. 258 1076810773.
  • 42
    Sevetson B.R., Kong X., Lawrence J.C.J r. (1993) Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 90 1030510309.
  • 43
    Sheng M., McFadden G., Greenberg M. (1990) Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 4 571582.
  • 44
    Sheng M., Thompson M.A., Greenberg M.E. (1991) CREB: a Ca2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252 14271430.
  • 45
    Sicheri F., Moarefi I., Kuriyan J. (1997) Crystal structure of the Src family tyrosine kinase Hck. Nature 385 602609.
  • 46
    Simonson M.S. & Herman W.H. (1993) Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signalling by endothelin-1: cross-talk between G protein-coupled receptors and pp60c-src. J. Biol. Chem. 268 93479357.
  • 47
    Sonnenberg J.L., Rauscher F.J.III, Morgan J.I., Curran T. (1989) Regulation of proenkephalin by Fos and Jun. Science 246 16221625.
  • 48
    Sun P. & Maurer R.A. (1995) An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation. J. Biol. Chem. 270 70417044.
  • 49
    Sun G., Ke S., Budde R.J. (1997) Csk phosphorylation and inactivation in vitro by the cAMP-dependent protein kinase. Arch. Biochem. Biophys. 343 194200.DOI: 10.1006/abbi.1997.0156
  • 50
    Szabo I., Gulbins E., Apfel H., Zhang X., Barth P., Busch A.E., Schlottmann K., Pongs O., Lang F. (1996) Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation. J. Biol. Chem. 271 2046520469.
  • 51
    Tan Y., Rouse J., Zhang A., Cariati S., Cohen P., Comb M.J. (1996) FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 15 46294642.
  • 52
    Thompson M.A., Ginty D.D., Bonni A., Greenberg M.E. (1995) L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. J. Biol. Chem. 270 42244235.
  • 53
    Vallejo M., Ron D., Miller C.P., Habener J.F. (1993) C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc. Natl. Acad. Sci. USA 90 46794683.
  • 54
    Walton K.M., Rehfuss R.P., Chrivia J.C., Lochner J.E., Goodman R.H. (1992) A dominant repressor of cyclic adenosine 3′,5′-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo. Mol. Endocrinol. 6 647655.
  • 55
    Wooten M.W., Seibenhener M.L., Matthews L.H., Zhou G., Coleman E.S. (1996) Modulation of ζ-protein kinase C by cyclic AMP in PC12 cells occurs through phosphorylation by protein kinase A. J. Neurochem. 67 10231031.
  • 56
    Xie W. & Herschman H.R. (1995) v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J. Biol. Chem. 270 2762227628.
  • 57
    Xu W., Harrison S.C., Eck M.J. (1997) Three-dimensional structure of the tyrosine kinase c-Src. Nature 385 595602.
  • 58
    Yaciuk P., Choi J.K., Shalloway D. (1989) Mutation of amino acids in pp60c-src that are phosphorylated by protein kinases C and A. Mol. Cell. Biol. 9 24532463.
  • 59
    Yamamoto K.K., Gonzalez G.A., Biggs W.H.III, Montminy M.R. (1988) Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334 494498.
  • 60
    Yu X., Askalan R., Keil G.J.II, Salter M.W. (1997) NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 275 674678.DOI: 10.1126/science.275.5300.674