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Prostate Apoptosis Response-4 Mediates Trophic Factor Withdrawal-Induced Apoptosis of Hippocampal Neurons

Actions Prior to Mitochondrial Dysfunction and Caspase Activation

  1. Sic L. Chan,
  2. Steven P. Tammariello,
  3. Steve Estus,
  4. Mark P. Mattson

Article first published online: 18 JAN 2002

DOI: 10.1046/j.1471-4159.1999.0730502.x

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Journal of Neurochemistry

Journal of Neurochemistry

Volume 73, Issue 2, pages 502–512, August 1999

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Chan, S. L., Tammariello, S. P., Estus, S. and Mattson, M. P. (1999), Prostate Apoptosis Response-4 Mediates Trophic Factor Withdrawal-Induced Apoptosis of Hippocampal Neurons. Journal of Neurochemistry, 73: 502–512. doi: 10.1046/j.1471-4159.1999.0730502.x

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* Address correspondence and reprint requests to Dr. M. P. Mattson at 211 Sanders-Brown Building, University of Kentucky, Lexington, Kentucky, KY 40536-0230, U.S.A.

  1. Abbreviations used : Aβ, amyloid β-peptide ; DCF, 2,7-dichlorofluorescein ; DEVD-CHO, N-acetyl-Asp-Glu-Val-Asp-aldehyde ; DHR, dihydrorhodamine-123 ; Par-4, prostate apoptosis response-4 ; PBS, phosphate-buffered saline ; ROS, reactive oxygen species ; TBARS, thiobarbituric acid-reactive species ; TFW, trophic factor withdrawal.

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  1. Issue published online: 18 JAN 2002
  2. Article first published online: 18 JAN 2002

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Acknowledgements

We thank V. Rangnekar for providing Par-4 antibody and W. Fu, J. Partin, and L. Yan for technical assistance. This work was supported by grants AG14554, AG05144, and NS35253 from the National Institutes of Health (to M.P.M.).

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