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Acknowledgements

We thank Dr. R. Milner from the Wellcome/CRC Institute of Cambridge (U.K.) for critical reading of the manuscript. We are also grateful to Dr. Y. Laperche from the Unité INSERM 99, Créteil (France), Dr. X. T. Do from the Laboratory of Biochemistry of the Faculty of Pharmacy of Angers (France), and Prof. P. Allain from the Laboratory of Toxicology-Pharmacology of the Centre Hospitalier Universitaire of Angers (France). Funds were provided by the Institut National de la Santé et de la Recherche Médicale (INSERM). E.G. was a postdoctoral fellow supported by the Association pour la Recherche sur la Sclérose en Plaques (ARSEP).

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