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Acknowledgements

The authors wish to thank Dr. M. Del Bigio for helpful comments. Research was supported by grants from the Medical Research Council of Canada. F.E.P. is a Scholar of the Medical Research Council of Canada. C.E.C. is a Terry Fox Cancer Research Scientist of the National Cancer Institute of Canada. J.D.Y. is a Heritage Medical Scientist of the Alberta Heritage Foundation for Medical Research. C.M.A. is a trainee of the Heart and Stroke Foundation of Canada.

  • 1
    Anderson C.M., Sitar D.S., Parkinson F.E. (1996a) Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats.Neurosci. Lett. 219,191194.
  • 2
    Anderson C.M., Xiong W., Young J.D., Cass C.E., Parkinson F.E. (1996b) Demonstration of the existence of mRNAs encoding N1/cif and N2/cit sodium/nucleoside cotransporters in rat brain.Mol. Brain Res. 42,358361.
  • 3
    Bisserbe J.C., Patel J., Marangos P.J. (1985) Autoradiographic localization of adenosine uptake sites in rat brain using [3H]nitrobenzylthioinosine. J. Neurosci. 5,544550.
  • 4
    Cass C.E. (1995) Nucleoside transport, inDrug Transport in Antimicrobial and Anticancer Chemotherapy (Georgopapadakou N. H., ed), pp. 403450. Marcel Dekker, New York.
  • 5
    Crawford C.R., Patel D.H., Naeve C., Belt J.A. (1998) Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line.J. Biol. Chem. 273,52885293.
  • 6
    Dar M.S. (1997) Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination : possible involvement of cAMP.Brain Res. 749,263274.
  • 7
    De Mendonça A. & Ribeiro J.A. (1994) Endogenous adenosine modulates long-term potentiation in the hippocampus.Neuroscience 62,358390.
  • 8
    De Mendonça A. & Ribeiro J.A. (1997) Adenosine and neuronal plasticity.Life Sci. 60,245251.
  • 9
    Fastbom J. & Fredholm B.B. (1990) Regional differences in the effect of guanine nucleotides on agonist and antagonist binding to adenosine A1-receptors in rat brain, as revealed by autoradiography.Neuroscience 34,759769.
  • 10
    Ferré S., Fredholm B.B., Morelli M., Popoli P., Fuxe K. (1997) Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia.Trends Neurosci. 20,482487.
  • 11
    Geiger J.D. & Nagy J.I. (1984) Heterogeneous distribution of adenosine transport sites labelled by [3H]nitrobenzylthioinosine in rat brain : an autoradiographic and membrane binding study. Brain Res. Bull. 13,657666.
  • 12
    Gidday J.M., Kim Y.B., Shah A.R., Gonzales E.R., Park T.S. (1996) Adenosine transport inhibition ameliorates postischemic hypoperfusion in pigs.Brain Res. 734,261268.
  • 13
    Glass M., Faull R.L., Dragunow M. (1996) Localisation of the adenosine uptake site in the human brain : a comparison with the distribution of adenosine A1 receptors.Brain Res. 710,7991.
  • 14
    Griffith D.A. & Jarvis S.M. (1996) Nucleoside and nucleobase transport systems of mammalian cells.Biochim. Biophys. Acta 1286,153181.
  • 15
    Griffiths M., Beaumont N., Yao S.Y.M., Sundaram M., Boumah C.E., Davies A., Kwong F.Y.P., Coe I., Cass C.E., Young J.D., Baldwin S.A. (1997) Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.Nat. Med. 3,8993.
  • 16
    Griffiths M., Yao S.Y.M., Abidi F., Phillips S.E.V., Cass C.E., Young J.D., Baldwin S.A. (1998) Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.Biochem. J. 328,739743.
  • 17
    Gu J.G. & Geiger J.D. (1992) Transport and metabolism of d-[3H]adenosine and l-[3H]adenosine in rat cerebral cortical synaptoneurosomes. J. Neurochem. 58,16991705.
  • 18
    Gu J.G., Nath A., Geiger J.D. (1996) Characterization of inhibitorsensitive and -resistant adenosine transporters in cultured human fetal astrocytes.J. Neurochem. 67,972977.
  • 19
    Haas H.L. & Greene R.W. (1988) Endogenous adenosine inhibits hippocampal CA1 neurones : further evidence from extra- and intracellular recording.Naunyn Schmiedebergs Arch. Pharmacol. 337,561565.
  • 20
    Hada J., Kaku T., Morimoto K., Hayashi Y., Nagai K. (1996) Adenosine transport inhibitos enhance high K(+)-evoked taurine release from rat hippocampus.Eur. J. Pharmacol. 305,101107.
  • 21
    Hammond J.R. & Clanachan A.S. (1985) Species differences in the binding of [3H]nitrobenzylthioinosine to the nucleoside transport system in mammalian central nervous system membranes : evidence for interconvertible conformations of the binding site/transporter complex. J. Neurochem. 45,527535.
  • 22
    Lee C.W. & Jarvis S.M. (1988) Nucleoside transport in rat cerebralcortical synaptosomes. Evidence for two types of nucleoside transporters.Biochem. J. 249,557564.
  • 23
    Miller L.P. & Hsu C. (1992) Therapeutic potential for adenosine receptor activation in ischemic brain injury.J. Neurotrauma 9 (Suppl. 2) , S563S577.
  • 24
    Ohkubo T., Mitsumoto Y., Mohri T. (1991) Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives.Neurosci. Lett. 133,275278.
  • 25
    Porkka-Heiskanen T., Strecker R.E., Thakkar M., Bjorkum A.A., Greene R.W., McCarley R.W. (1997) Adenosine : a mediator of the sleep-inducing effects of prolonged wakefulness.Science 276,12651268.
  • 26
    Reppert S.M., Weaver D.R., Stehle J.H., Rivkees S.A. (1991) Molecular cloning and characterization of a rat A1 adenosine receptor that is widely expressed in brain and spinal cord.Mol. Endocrinol. 5,10371048.
  • 27
    Rudolphi K.A., Schubert P., Parkinson F.E., Fredholm B.B. (1992) Neuroprotective role of adenosine in cerebral ischaemia.Trends. Pharmacol. Sci. 13,439445.
  • 28
    Sawynok J. (1998) Adenosine receptor activation and nociception.Eur. J. Pharmacol. 347,111.
  • 29
    Sebastião A.M. & Ribeiro J.A. (1996) Adenosine A2 receptor-mediated excitatory actions on the nervous system.Prog. Neurobiol. 48,167189.
  • 30
    Simmons D.M., Arriza J.L., Swanson L.W. (1989) A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes.J. Histotechnol. 12,169181.
  • 31
    Sollevi A. (1997) Adenosine for pain control.Acta Anaesthesiol. Scand. Suppl. 110,135136.
  • 32
    Sweeney M.I. (1996) Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins.J. Neurochem. 67,8188.
  • 33
    Tso J.Y., Sun X.H., Kao T.H., Reece K.S., Wu R. (1985) Isolation and characterization of rat and human glyceraldehyde 3′ phosphate dehydrogenase cDNAs : genomic complexity and molecular evolution of the gene.Nucleic Acids Res. 13,24852502.
  • 34
    Von Lubitz D.K.J.E., Carter M.F., Beenhakker R., Lin C., Jacobson K.A. (1997) Adenosine : a prototherapeutic concept in neurodegeneration.Ann. NY Acad. Sci. 825,163178.
  • 35
    Winn H.R., Rubio R., Berne R.M. (1981) The role of adenosine in the regulation of cerebral blood flow.J. Cereb. Blood Flow Metab. 1,239244.
  • 36
    Yao S.Y.M., Ng A.M.L., Muzyka W.R., Griffiths M., Cass C.E., Baldwin S.A., Young J.D. (1997) Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues.J. Biol. Chem. 272,2842328430.
  • 37
    Zhang G., Franklin P.H., Murray T.F. (1993) Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.J. Pharmacol. Exp. Ther. 264,14151424.