• 1
    Aksenov M.Y., Aksenova M.V., Payne R.M., Smith C.D., Markesbery W.R., Carney J.M. (1977) The expression of creatine kinase isoenzymes in neocrotex of patients with neurodegenerative disorders : Alzhemer's and Pick's disease.Exp. Neurol. 146,458465.
  • 2
    Beal M.F. (1994) Energy, oxidative damage, and Alzheimer's disease : clues to the underlying puzzle.Neurobiol. Aging 15,S171S174.
  • 3
    Berlett B.S. & Stadtman E.R. (1997) Protein oxidation in aging, disease, and oxidative stress.J. Biol. Chem. 272,2031320316.
  • 4
    Brot N. & Weissbach H. (1983) Biochemistry and physiological role of methionine sulfoxide residues in proteins.Arch. Biochem. Biophys. 223,271281.
  • 5
    Brot N., Werth J., Koster D., Weissbach H. (1982) Reduction of N-acetyl methionine sulfoxide : a simple assay for peptide methionine sulfoxide reductase. Anal. Biochem. 122,291294.
  • 6
    Burbaeva G.S., Aksenova M.V., Makarenko I.G. (1992) Decreased level of creatine kinase BB in the frontal cortex of Alzheimer patients.Dementia 3,9194.
  • 7
    Carp H., Miller F., Hoidal J.R., Janoff A. (1982) Potential mechanism of emphysema : alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.Proc. Natl. Acad. Sci. USA 79,20412045.
  • 8
    Chomczynski P. & Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Anal. Biochem. 162,156159.
  • 9
    Ciorba M.A., Heinemann S.H., Weissbach H., Brot N., Hoshi T. (1997) Modulation of potassium channel function by methionine oxidation and reduction.Proc. Natl. Acad. Sci. USA 94,99329937.
  • 10
    Crapper-McLachlan D.R., Lukiw W.J., Wong L., Bergeron C., Bech-Hansen N.T. (1988) Selective messenger RNA reduction in Alzheimer's disease.Mol. Brain Res. 15,681690.
  • 11
    Gabbita S.P., Lovell M.A., Markesbery W.R. (1998) Increased nuclear DNA oxidation in the brain in Alzheimer's disease.J. Neurochem. 71,20342040.
  • 12
    Good P.F., Werner P., Hsu A., Olanow C.W., Perl D.P. (1996) Evidence of neuronal oxidative damage in Alzheimer's disease.Am. J. Pathol. 149,2128.
  • 13
    Guillemette J.G., Wong L., Crapper-McLachlan D.R., Lewis P.N. (1986) Characterization of messenger RNA from the cerebral cortex of control and Alzheimer-afflicted brain.J. Neurochem. 47,987997.
  • 14
    Hensley K., Hall N.C., Subramaniam R., Cole P., Harris M., Aksenov M.Y., Aksenova M.V., Gabbita S.P., Wu J.F., Carney J.M., Lovell M.A., Markesbery W.R., Butterfield D.A. (1995) Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.J. Neurochem. 65,21462156.
  • 15
    Hensley K., Maidt M.L., Yu Z., Sang H., Markesbery W.R., Floyd R.A. (1998) Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.J. Neurosci. 18,81268132.
  • 16
    Levine R.L., Mosoni L., Berlett B.S., Stadtman E.R. (1996) Methionine residues as endogenous antioxidants in proteins.Proc. Natl. Acad. Sci. USA 93,1503615040.
  • 17
    Lovell M.A., Ehmann W.D., Butler S.M., Markesbery W.R. (1995) Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease.Neurology 45,15941601.
  • 18
    Lovell M.A., Ehmann W.D., Mattson M.P., Markesbery W.R. (1997) Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.Neurobiol. Aging 18,457461.
  • 19
    Lovell M.A., Gabbita S.P., Markesbery W.R. (1999) Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.J. Neurochem. 72,771776.
  • 20
    Lyras L., Cairns N.J., Jenner A., Jenner P., Halliwell B. (1997) An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease.J. Neurochem. 68,20612069.
  • 21
    Maniatis T., Fritsch E.F., Sambrook J. (1982) Molecular Cloning : A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
  • 22
    Markesbery W.R. (1997) Oxidative stress hypothesis in Alzheimer's disease.Free Radic. Biol. Med. 23,134147.
  • 23
    Markesbery W.R. & Carney J.M. (1999) Oxidative alterations in Alzheimer's disease.Brain Pathol. 9,133146.
  • 24
    Markesbery W.R. & Lovell M.A. (1998) Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.Neurobiol. Aging 19,3336.
  • 25
    McKhann G.D., Drachman D.A., Folstein M.F., Katzman R., Price D., Stadlan E.M. (1984) Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease.Neurology 34,939944.
  • 26
    Mecocci P., MacGarvey U., Beal M.F. (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease.Ann. Neurol. 36,747751.
  • 27
    Montine T.J., Markesbery W.R., Morrow J.D., Roberts L.J. (1998) Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Ann. Neurol. 44,410413.
  • 28
    Moskovitz J., Jenkins N.A., Gilbert D.J., Copeland N.G., Jursky F., Weissbach H., Brot N. (1996 a) Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues. Proc. Natl. Acad. Sci. USA 93,32053208.
  • 29
    Moskovitz J., Weissbach H., Brot N. (1996 b) Cloning and expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins. Proc. Natl. Acad. Sci. USA 93,20952099.
  • 30
    Moskovitz J., Flescher E., Berlett B.S., Azare J., Poston J.M., Stadtman E.R. (1998) Overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress.Proc. Natl. Acad. Sci. USA 95,1407114075.
  • 31
    National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of A & 's D isease (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease.Neurobiol. Aging 18,S1S2.
  • 32
    Oliver C.N., Starke-Reed P.E., Stadtman E.R., Liu G.J., Carney J.M., Floyd R.A. (1990) Oxidative damage to brain proteins, loss of glutamine synthetase activity and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.Proc. Natl. Acad. Sci. USA 87,51445147.
  • 33
    Paik W.K. & Kim S. (1975) Protein methylation : chemical, enzymological, and biological significance.Adv. Enzymol. Relat. Areas Mol. Biol. 42,227286.
  • 34
    Prasad M.R., Lovell M.A., Yatin M., Dhillon H., Markesbery W.R. (1998) Regional membrane phospholipid alterations in Alzheimer's disease.Neurochem. Res. 23,8188.
  • 35
    Roberts L.J., Montine T.J., Markesbery W.R., Tapper A.R., Hardy P., Chemotob S., Dettbarn W.D., Morrow J.D. (1998) Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid.J. Biol. Chem. 273,1360513612.
  • 36
    Sajdel-Sulkowska E.M. & Marotta C.A. (1984) Alzheimer's disease brain : alterations in RNA levels and in a ribonuclease-inhibitor complex.Science 225,947949.
  • 37
    Smith C.D., Starke-Reed P., Oliver C.N., Stadtman E.R., Carney J.M., Markesbery W.R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer's disease.Proc. Natl. Acad. Sci. USA 88,1054010543.
  • 38
    Smith M.A., Sayre L.M., Monnier V.M., Perry G. (1995) Radical AGEing in Alzheimer's disease.Trends Neurosci. 18,172176.
  • 39
    Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., Kowall N. (1996) Oxidative damage in Alzheimer's.Nature 382,120121.
  • 40
    Stadtman E.R. (1992) Protein oxidation and aging.Science 257,12201224.
  • 41
    Subbarao K.V., Richardson J.S., Ang L.C. (1990) Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro.J. Neurochem. 55,342345.
  • 42
    Swaim M.W. & Pizzo S.V. (1988) Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors.J. Leukoc. Biol. 43,365379.
  • 43
    Vogt W. (1995) Oxidation of methionyl residues in proteins : tools, targets, and reversal.Free Radic. Biol. Med. 18,93105.