Lippincott Williams & Wilkins, Inc., Philadelphia
Distinct Secretases, a Cysteine Protease and a Serine Protease, Generate the C Termini of Amyloid β-Proteins Aβ1-40 and Aβ1-42, Respectively
Article first published online: 25 DEC 2001
Journal of Neurochemistry
Volume 72, Issue 4, pages 1417–1422, April 1999
How to Cite
Figueiredo-Pereira, M. E., Efthimiopoulos, S., Tezapsidis, N., Buku, A., Ghiso, J., Mehta, P. and Robakis, N. K. (1999), Distinct Secretases, a Cysteine Protease and a Serine Protease, Generate the C Termini of Amyloid β-Proteins Aβ1-40 and Aβ1-42, Respectively. Journal of Neurochemistry, 72: 1417–1422. doi: 10.1046/j.1471-4159.1999.721417.x
Drs. M. E. Figueiredo-Pereira and S. Efthimiopoulos made equal contributions to this article.
Abbreviations used: Aβ, amyloid β-protein; Ac-LLnL-CHO, acetyl-Leu-Leu-norleucinal; APP, amyloid precursor protein; APPsα, APP secreted product of α-secretase; APPsβ, APP secreted product of β-secretase; CHO, Chinese hamster ovary; CHOsw and CHOvg, CHO cells transfected with APP751 cDNA carrying either the Swedish double mutation or the valine-to-glycine London mutation, respectively; CHOwt, CHO cells transfected with human wild-type APP751 cDNA; E-64d, (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methyl-butane ethyl ester; Z-LL-CHO, N-benzyloxycarbonyl-Leu-leucinal; Z-VF-CHO, N-benzyloxycarbonyl-Val-phenylalaninal; Z-VL-CHO, N-benzyloxycarbonyl-Val-leucinal.
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
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