• 1
    Alderson R.F., Alterman A.L., Barde Y., Lindsay R.M. (1990) Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture.Neuron 5 297306.
  • 2
    Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.J. Biol. Chem. 270 2748927494.
  • 3
    Alonso A., Faure M., Beaudet A. (1994) Neurotensin promotes oscillatory bursting behavior and is internalized in basal forebrain cholinergic neurons.J. Neurosci. 14 57785792.
  • 4
    Androutsellis-Theotokis A., McCormack W.J., Bradford H.F., Stern G.M., Pliego-Rivero F.B. (1996) The depolarisation-induced release of [125I]BDNF from brain tissue. Brain Res. 743 4048.
  • 5
    Barker P. & Shooter E. (1994) Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells.Neuron 13 203215.
  • 6
    Batchelor P.E., Armstrong D.M., Blaker S.N., Gage F.H. (1989) Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: response to fimbriafornix transection.J. Comp. Neurol. 84 187204.
  • 7
    Bejanin S., Cervini R., Mallet J., Berrard S. (1994) A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine.J. Biol. Chem. 269 2194421947.
  • 8
    Bendetti M., Levi A., Chao M.V. (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.Proc. Natl. Acad. Sci. USA 90 78597863.
  • 9
    Berg M.M., Sternberg D.W., Parada L., Chao M.V. (1992) K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.J. Biol. Chem. 267 1316.
  • 10
    Berninger B. & Poo M. -M. (1996) Fast actions of neurotrophic factors.Curr. Opin. Neurobiol. 6 324330.
  • 11
    Berninger B., Garcia D.E., Inagaki N., Hahnel C., Lindholm D. (1993) BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones.Neuroreport 4 13031306.
  • 12
    Berse B. & Blusztajn J.K. (1995) Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line.J. Biol. Chem. 270 2210122104.
  • 13
    Blöchl A. & Thoenen H. (1995) Characterization of nerve growth factor (NGF) release from hippocampal neurons: evidence for a constitutive and an unconventional sodium-dependent regulated pathway.Eur. J. Neurosci. 7 12201228.
  • 14
    Blöchl A. & Thoenen H. (1996) Localization of cellular storage compartments and sites of constitutive and activity-dependent release of nerve growth factor (NGF) in primary cultures of hippocampal neurons.Mol. Cell. Neurosci. 7 173190.
  • 15
    Boulanger L. & Poo M. -M. (1999) Gating of BDNF-induced synaptic potentiation by cAMP.Science 284 19821984.
  • 16
    Cheng B. & Mattson M.P. (1994) NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults.Brain Res. 607 275285.
  • 17
    Courtney M.J., Aring;kerman K.E.O., Coffey E.T. (1997) Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism.J. Neruosci. 17 42014211.
  • 18
    D'Arcangelo G., Paradiso K., Shepherd D., Brehm P., Halegoua S., Mandel G. (1993) Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways.J. Cell Biol. 122 915921.
  • 19
    David G., Barrett J.N., Barrett E.F. (1997) Spatiotemporal gradients of intra-axonal [Na+] after transection and resealing in lizard peripheral myelinated axons. J. Physiol. (Lond.) 498 295307.
  • 20
    Davies A.M., Lee K., Jaenisch R. (1993) p75-deficient trigeminal sensory neurons have an altered response to NGF but not other neurotrophins.Neuron 11 565574.
  • 21
    Dawbarn D., Allen S.U., Semenenko F.M. (1988) Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain.Neurosci. Lett. 94 138144.
  • 22
    Dudley D.T., Pang L., Decker S.J., Bridges A.J., Saltiel A.R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade.Proc. Natl. Acad. Sci. USA 92 76867689.
  • 23
    Enslen H., Sun P., Brickey D., Soderling S.H., Klamo E., Soderling T.R. (1994) Characterization of Ca2+/calmodulin-dependent protein kinase IV: role in transcriptional regulation. J. Biol. Chem. 269 1552015527.
  • 24
    Erickson J.D., Varoqui H., Schäfer M.K., Modi W., Diebler M., Weihe E., Rand J., Eiden L.E., Bonner T.I., Usdin T.B. (1994) Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus.J. Biol. Chem. 269 2192921932.
  • 25
    Finkbeiner S. & Greenberg M.E. (1996) Ca2+-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron 16 233236.
  • 26
    Finkbeiner S., Tavazoie S.F., Maloratsky A., Jacobs K.M., Harris K.M., Greenberg M.E. (1997) CREB: a major mediator of neuronal neurotrophin responses.Neuron 19 10311047.
  • 27
    Fonnum R. (1969) Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.Biochem. J. 115 465472.
  • 28
    Friedman W.J., Ibáñez C.F., Hallbook F., Persson H., Cain L.D., Dreyfus C.F., Black I.B. (1993) Differential actions of neurotrophins in the locus coeruleus and basal forebrain.Exp. Neurol. 119 7278.
  • 29
    Gibbs R.B. & Pfaff D.W. (1994) In situ hybridization detection of trkA mRNA in brain: distribution, co-localization with p75NGFR and up-regulation by nerve growth factor.J. Comp. Neurol. 341 324339.
  • 30
    Goodman L.J., Valverde J., Lim F., Geschwind M.D., Federoff H.J., Geller A.I., Hefti F. (1996) Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons.Mol. Cell. Neurosci. 7 222238.
  • 31
    Gundersen R. & Barrett J.N. (1979) Neuronal chemotaxis: chick dorsal root axons turn toward elevated concentrations of nerve growth factor.Science 206 10791080.
  • 32
    Gundersen R. & Barrett J.N. (1980) Characterization of the turning response of dorsal root neurites toward nerve growth factor.J. Cell Biol. 87 546554.
  • 33
    Hantzopoulos P.A., Suri C., Glass D.J., Goldfarb M.P., Yancopoulos G.D. (1994) The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins.Neuron 13 187201.
  • 34
    Hempstead B.L., Martin-Zanca D., Kaplan D.R., Parada L.F., Chao M.V. (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.Nature 350 678683.
  • 35
    Holtzman D.M., Li Y., Parada L.F., Kinsman S., Chen C., Valetta J.S., Zhou J., Long J.B., Mobley W.C. (1992) p140trk mRNA marks the NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.Neuron 9 465478.
  • 36
    Huber L.J. & Chao M.V. (1995) A potential interaction of p75 and trkA NGF receptors demonstrated by affinity cross-linking and immunoprecipitation.J. Neurosci. Res. 40 557563.
  • 37
    Kang H.J. & Schuman E.M. (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus.Science 267 16581662.
  • 38
    Kaufman L.M. & Barrett J.N. (1983) Serum factor supporting long-term survival of rat central neurons in culture.Science 220 13941396.
  • 39
    Kawamoto J.C. & Barrett J.N. (1986) Cryopreservation of primary neurons for tissue culture.Brain Res. 384 84-93.
  • 40
    Knipper M., Leung L.S., Zhao D., Rylett R.J. (1994a) Short-term modulation of glutamatergic synapses in adult rat hippocampus by NGF.Neuroreport 5 24332436.
  • 41
    Knipper M., da Penha Berzaghi M., Blöchl A., Breer H., Thoenen H., Lindholm D. (1994b) Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus.Eur. J. Neurosci. 6 668671.
  • 42
    Knüsel B. & Hefti F. (1992) K-252 compounds: modulators of neurotrophin signal transduction.J. Neurochem. 59 19871996.
  • 43
    Knüsel B., Rabin S., Widmer H.R., Hefti F., Kaplan D.R. (1992) Neurotrophin induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons.Neuroreport 3 885888.
  • 44
    Lessmann V., Gottmann K., Heumann R. (1994) BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones.Neuroreport 6 2125.
  • 45
    Levine E., Dreyfus C., Black I., Plummer M. (1995) Differential effects of NGF and BDNF on voltage-gated calcium currents in embryonic basal forebrain neurons.J. Neurosci. 15 30843091.
  • 46
    Li Y., Holtzman D.M., Kromer L.F., Kaplan D.R., Chua-Couzens J., Clary D.O., Knüsel B., Mobley W.C. (1995) Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.J. Neurosci. 15 28882905.
  • 47
    Lohof A.M., Ip N.Y., Poo M. -M. (1993) Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.Nature 363 350353.
  • 48
    Mahadeo D., Kaplan L., Chao M.V., Hempstead B.L. (1994) High affinity nerve growth factor binding displays a faster rate of association than p140trk binding: implications for multi-subunit polypeptide receptors.J. Biol. Chem. 269 68846891.
  • 49
    Marsh H.N. & Palfrey H.C. (1996) Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons.J. Neurochem. 67 952963.
  • 50
    Marsh H.N., Scholz W.K., Lamballe F., Klein R., Nanduri V., Barbacid M., Palfrey H.C. (1993) Signal transduction events mediated by the BDNF receptor gp145trkB in primary hippocampal pyramidal cell culture.J. Neurosci. 13 42814292.
  • 51
    McAllister A.K., Katz L.C., Lo D.C. (1996) Neurotrophin regulation of cortical dendritic growth requires activity.Neuron 17 10571064.
  • 52
    Merlio J.P., Ernfors P., Persson H. (1992) Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for the members of the trk family in the rat central nervous system.Neuroscience 51 513532.
  • 53
    Merritt J.E., Jacob R., Hallam T.J. (1989) Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils.J. Biol. Chem. 264 15221527.
  • 54
    Meyer-Franke A., Wilkinson G.A., Kruttgen A., Hu M., Munro E., Hanson M.G.J, Reichardt L.F., Barres B.A. (1998) Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons.Neuron 21 681693.
  • 55
    Moises H.C., Womble M.D., Washburn M.S., Williams L.R. (1995) Nerve growth factor facilitates cholinergic neurotransmission between nucleus basalis and the amygdala in rat: an electrophysiological analysis.J. Neurosci. 15 81318142.
  • 56
    Muroya K., Hashimoto Y., Hattori S., Nakamura S. (1992) Specific inhibition of NGF receptor tyrosine kinase activity by K-252a.Biochim. Biophys. Acta 1135 353356.
  • 57
    Nonner D., Brass B.J., Barrett E.F., Barrett J.N. (1993) Reversibility of nerve growth factor's enhancement of choline acetyltransferase activity in cultured embryonic rat septum.Exp. Neurol. 122 196208.
  • 58
    Nonner D., Barrett E.F., Barrett J.N. (1996) Neurotrophin effects on survival and expression of cholinergic properties in cultured rat septal neurons under normal and stress conditions.J. Neurosci. 16 66656675.
  • 59
    Nonomura T., Nishio C., Lindsay R.M., Hatanaka H. (1995) Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins.Brain Res. 683 129139.
  • 60
    Nye S.H., Squinto S.P., Glass D.J., Stitt T.N., Hantzopoulos P., Macchi M.J., Lindsay N.S., Ip N.Y., Yancopoulos G.D. (1992) K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.Mol. Biol. Cell 3 677686.
  • 61
    Pang L., Sawada T., Decker S.J., Saltiel A.R. (1995) Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.J. Biol. Chem. 270 1358513588.
  • 62
    Pongrac J.L. & Rylett R.J. (1998) NGF-induction of the expression of ChAT mRNA in PC12 cells and primary cultures of embryonic rat basal forebrain.Brain Res. Mol. Brain Res. 62 2534.
  • 63
    Quirin-Stricker C., Mauvais C., Schmitt M. (1997) Transcriptional activation of human choline acetyltransferase by AP2- and NGF-induced factors.Mol. Brain Res. 49 165174.
  • 64
    Rodríguez-Tébar A., Dechant G., Barde Y. -A. (1990) Binding of brain-derived neurotrophic factor to the nerve growth factor receptor.Neuron 4 487492.
  • 65
    Rodríguez-Tébar A., Dechant G., Götz R., Barde Y. -A. (1992) Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.EMBO J. 11 917922.
  • 66
    Sobreviela T., Clary D.O., Reichardt L.F., Bradabur M.M., Mufson E.J. (1994) TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin.J. Comp. Neurol. 350 587611.
  • 67
    Steininger T.L., Wainer B.H., Klein R., Barbacid M., Palfrey H.C. (1993) High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain.Brain Res. 612 330335.
  • 68
    Stoop R. & Poo M. -M. (1996) Synaptic modulation by neurotrophic factors: differential and synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor.J. Neurosci. 16 32563264.
  • 69
    Szigethy E., Leonard K., Beaudet A. (1990) Ultrastructural localization of [I125]neurotensin binding sites to cholinergic neurons of the rat nucleus basalis magnocellularis. Neuroscience 36 377391.
  • 70
    Tanaka T., Saito H., Matsuki N. (1997) Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus.J. Neurosci. 17 29592966.
  • 71
    Tapley P., Lamballe F., Barbacid M. (1992) K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.Oncogene 7 371381.
  • 72
    Tedeschi B., Barrett J.N., Keane R.W. (1986) Astrocytes produce interferon that enhances the expression of H-2 antigens on a subpopulation of brain cells.J. Cell Biol. 102 22442253.
  • 73
    Thoenen H. (1995) Neurotrophins and neuronal plasticity.Science 270 593598.
  • 74
    Tokumitsu H., Chijiwa T., Hagiwara M., Mizutani A., Terasawa M., Hidaka H. (1990) KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin dependent protein kinase II. J. Biol. Chem. 265 43154320.
  • 75
    Toledo-Aral J.J., Brehm P., Halegoua S., Mandel G. (1995) A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction.Neuron 14 607611.
  • 76
    Toussaint J.L., Geoffrey V., Schmitt M., Werner A., Garnier J.M., Simoni P., Kempf J. (1992) Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.Genomics 12 412416.
  • 77
    Ure D.R. & Campenot R.B. (1997) Retrograde transport and steady-state distribution of 125I-nerve growth factor in rat sympathetic neurons in compartmented cultures. J. Neurosci. 17 12821290.
  • 78
    Verdi J.M., Birren S.J., Ibáñez C.F., Persson H., Kaplan D.R., Benedetti M., Chao M.V., Anderson D.J. (1994) p75NTR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells.Neuron 12 733745.
  • 79
    Whittemore S.R. and Seiger Å. (1987) The expression, localization and functional significance of β-nerve growth factor in the central nervous system. Brain Res. Rev. 12 439464.
  • 80
    Yan J. & Barrett J.N. (1998) Purification from bovine serum of a survival-promoting factor for cultured central neurons and its identification as selenoprotein-P.J. Neurosci. 18 86828691.