• 1
    Basu S.K., Goldstein J.L., Brown M.S. (1983) Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages.Science 219 871873.
  • 2
    Bellosta S., Nathan B.P., Orth M., Dong L.M., Mahley R.W., Pitas R.E. (1995) Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produce differential effects on neurite outgrowth.J. Biol. Chem. 270 2706327071.
  • 3
    Bernard D.W., Rodriguez A., Rothblat G.H., Glick J.M. (1991) cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.J. Biol. Chem. 266 710716.
  • 4
    Bickeboller H., Campion D., Brice A., Amouyel P., Hannequin D., Didierjean O., Penet C., Martin C., Perez-Tur J., Michon A., Dubois B., Ledoze F., Thomas-Anterion C., Pasquier F., Puel M., Demonet J.F., Moreaud O., Babron M.C., Meulien D., Guez D., Chartier-Harlin M.C., Frebourg T., Agid Y., Martinez M., Clerget-Darpoux F. (1997) Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.Am. J. Hum. Genet. 60 439446.
  • 5
    Bielicki J.K., Johnson W.J., Weinberg R.B., Glick J.M., Rothblat G.H. (1992) Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.J. Lipid Res. 33 16991709.
  • 6
    Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.Science 261 921923.
  • 7
    Cullen P., Cignarella A., Brennhausen B., Mohr S., Assmann G., von Eckardstein A. (1998) Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.J. Clin. Invest. 101 16701677.
  • 8
    Forte T.M., Goth-Goldstein R., Nordhausen R.W., McCall M.R. (1993) Apolipoprotein A-I—cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles. J. Lipid Res. 34 317324.
  • 9
    Hara H. & Yokoyama S. (1991) Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.J. Biol. Chem. 266 30803086.
  • 10
    Hara H. & Yokoyama S. (1992) Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-beta high-density lipoprotein pathway.Biochemistry 31 20402046.
  • 11
    Hara H., Komaba A., Yokoyama S. (1992) Alpha-helical requirements for free apolipoproteins to generate HDL and to induce cellular lipid efflux.Lipids 27 302304.
  • 12
    Holtzman D.M., Pitas R.E., Kilbridge J., Nathan B., Mahley R.W., Bu G., Schwartz A.L. (1995) Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite out-growth in a CNS-derived neuronal cell line.Proc. Natl. Acad. Sci. USA 92 94809484.
  • 13
    Huang Y., von Eckardstein A., Wu S., Maeda N., Assmann G. (1994) A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells.Proc. Natl. Acad. Sci. USA 91 18341838.
  • 14
    Isobe I., Michikawa M., Yanagisawa K. (1999) Enhancement of MTT, a tetrazolium salt, exocytosis by amyloid β-protein and chloroquine. Neurosci. Lett. 266 129132.
  • 15
    Ito J., Zhang L., Asai M., Yokoyama S. (1999) Differential generation of high-density lipoprotein by endogenous and exogenous apolipoproteins in cultured fetal rat astrocytes.J. Neurochem. 72 23622369.
  • 16
    Ji Z.S., Dichek H.L., Miranda R.D., Mahley R.W. (1997) Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins.J. Biol. Chem. 272 3128531292.
  • 17
    Ji Z.S., Pitas R.E., Mahley R.W. (1998) Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than E4.J. Biol. Chem. 273 1345213460.
  • 18
    Johnson W.J., Mahlberg F.H., Rothblat G.H., Phillips M.C. (1991) Cholesterol transport between cells and high-density lipoproteins.Biochim. Biophys. Acta 1085 273298.
  • 19
    Karlin J.B., Johnson W.J., Benedict C.R., Chacko G.K., Phillips M.C., Rothblat G.H. (1987) Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to the cell surface.J. Biol. Chem. 262 1255712564.
  • 20
    Kruth H.S., Skarlatos S.I., Gaynor P.M., Gamble W. (1994) Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.J. Biol. Chem. 269 2451124518.
  • 21
    Kuwano M., Miida T., Fielding C.J., Fielding P.E. (1993) Quantitation of pre-β-HDL and nonspecific components of the total efflux of cellular cholesterol and phospholipid. Biochemistry 32 50255028.
  • 22
    LaDu M.J., Gilligan S.M., Lukens J.R., Cabana V.G., Reardon C.A., Van Eldik L.J., Holtzman D.M. (1998) Nascent astrocyte particles differ from lipoproteins in CSF.J. Neurochem. 70 20702081.
  • 23
    Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature 227 680685.
  • 24
    Li Q. & Yokoyama S. (1995) Independent regulation of cholesterol incorporation into free apolipoprotein-mediated cellular lipid efflux in rat vascular smooth muscle cells.J. Biol. Chem. 270 2621626223.
  • 25
    Li Q., Komaba A., Yokoyama S. (1993) Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells.Biochemistry 32 45974603.
  • 26
    Li Q., Czarnecka H., Yokoyama S. (1995) Involvement of a cellular surface factor(s) in lipid-free apolipoprotein-mediated cellular cholesterol efflux.Biochim. Biophys. Acta 1259 227234.
  • 27
    Li Q., Tsujita M., Yokoyama S. (1997) Selective down-regulation by protein kinase C inhibitors of apolipoprotein-mediated cellular cholesterol efflux in macrophages.Biochemistry 36 1204512052.
  • 28
    Mahley R.W. (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.Science 240 622630.
  • 29
    Mazzone T. & Reardon C. (1994) Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.J. Lipid Res. 35 13451353.
  • 30
    Mendel C.M., Kunitake S.T., Kane J.P., Kempner E.S. (1988) Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes.J. Biol. Chem. 263 13141319.
  • 31
    Mendez A.J. (1995) Monensin and brefeldin A inhibit high density lipoprotein-mediated cholesterol efflux from cholesterol-enriched cells. Implications for intracellular cholesterol transport.J. Biol. Chem. 270 58915900.
  • 32
    Mendez A.J. (1997) Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion.J. Lipid Res. 38 18071821.
  • 33
    Mendez A.J. & Oram J.F. (1997) Limited proteolysis of high density lipoprotein abolishes its interaction with cell-surface binding sites that promote cholesterol efflux.Biochim. Biophys. Acta 1346 285299.
  • 34
    Mendez A.J., Oram J.F., Bierman E.L. (1991) Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol.J. Biol. Chem. 266 1010410111.
  • 35
    Michikawa M. & Yanagisawa K. (1998) Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis.J. Neurosci. Res. 54 5867.
  • 36
    Michikawa M. & Yanagisawa K. (1999a) Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death.J. Neurochem. 72 22782285.
  • 37
    Michikawa M. & Yanagisawa K. (1999b) Apolipoprotein E4 isoform-specific actions on neuronal cells in culture.Mech. Ageing Dev. 107 233243.
  • 38
    Oram J.F., Johnson C.J., Brown T.A. (1987) Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversible binding at the cell surface without internalization.J. Biol. Chem. 262 24052410.
  • 39
    Pitas R.E., Boyles J.K., Lee S.H., Hui D., Weisgraber K.H. (1987) Lipoproteins and their receptors in the CNS—characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain. J. Biol. Chem. 262 1435214360.
  • 40
    Poirier J., Davignon J., Bouthillier D., Kogan S., Bertrand P., Gauthier S. (1993) Apolipoprotein E polymorphism and Alzheimer's disease.Lancet 342 697699.
  • 41
    Roheim P.S., Carey M., Forte T., Vega G.L. (1979) Apolipoproteins in human cerebrospinal fluid.Proc. Natl. Acad. Sci. USA 76 46464649.
  • 42
    Saunders A.M., Strittmatter W.J., Schmechel D., George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J., Hulette C., Crain B., Goldgaber D., Roses A.D. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.Neurology 43 14671472.
  • 43
    Smith J.D., Miyata M., Ginsberg M., Grigaux C., Shmookler E., Plump A.S. (1996) Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors.J. Biol. Chem. 271 3064730655.
  • 44
    Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D. (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proc. Natl. Acad. Sci. USA 90 19771981.
  • 45
    Theret N., Delbart C., Aguie G., Fruchart J.C., Vasssaux G., Ailhaud G. (1990) Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation.Biochem. Biophys. Res. Commun. 173 13611368.
  • 46
    Tsujita M. & Yokoyama S. (1996) Selective inhibition of free apolipoprotein-mediated cellular lipid efflux by probucol.Biochemistry 35 1301113020.
  • 47
    Urbani L. & Simoni R.D. (1990) Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.J. Biol. Chem. 265 19191923.
  • 48
    Voyno-Yasenetskaya T.A., Dobbs L.G., Erickson S.K., Hamilton R.L. (1993) Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells.Proc. Natl. Acad. Sci. USA 90 42564260.
  • 49
    Weisgraber K.H. (1994) Apolipoprotein E: structure-function relationships.Adv. Protein Chem. 45 249302.
  • 50
    Yokoyama S. (1998) Apolipoprotein-mediated cellular cholesterol efflux.Biochim. Biophys. Acta 1392 115.
  • 51
    Zhang W.Y., Gaynor P.M., Kruth H.S. (1996) Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors.J. Biol. Chem. 271 2864128646.