We wish to thank Susan M. Mockus and George J. Yohrling IV (Wake Forest University School of Medicine) for preparing recombinant TPH and TH proteins and providing valuable technical advice. We also thank Dr. D. Kowlessur and Dr. S. Kaufman (National Institutes of Health) for phenylalanine hydroxylase activity determinations. This work was supported by grants GM 38931 (to K.E.V.), DK52139 (to H.T.), T32 DA 07246 (to A.H.S.), and DA 05822 (to J.A.D.) from the National Institutes of Health. Y.X. was a Wake Forest University School of Medicine/RJR-Leon Golberg Postdoctoral Toxicology Fellow.

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