This research was supported by the Medical Research Council of Canada (MRCC). Serge Rivest is an MRCC Scientist. Ji Zhang is supported by an MRCC Student-ship. The authors thank Dr. Mark Abramovitz (Merck Frosst Canada) for the generous gift of the rat EP4 cDNA, Dr. I. Verma (Salk Institute, La Jolla, CA, U.S.A.) for the rat c-fos cDNA, and Dr. J. Milbrandt (Washington University, St. Louis, MO, U.S.A.) for the rat NGFI-B cDNA. The authors also thank Ms. Nathalie Laflamme for invaluable technical assistance.

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