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Acknowledgements

We want to thank Dr. Y. Kubo (Tokyo Metropolitan Institute for Neuroscience) for discussions on the manuscript, A. Kushi, K. Akiyama, and Y. Yamasaki for helpful advice on mouse breeding, and S. Nakanishi for histology techniques. We also thank M. Kumai, K. Ishii, H. Nakano, M. Yamasaki, and I. Sugamuma for help in generating and caring for the deficient mice used in this study and S. Inoue and M. Saito for their expert technical assistance. We thank Dr. M. Takase for the EEG work and helpful discussions.

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