Human receptor cDNA clones were kindly provided by Jon Lindstrom. We thank Julia Porter and Jennifer Kruse for technical assistance. We also thank Jeannette Watterson for her contribution to a preliminary characterization of RJR-2403 on rat nicotinic receptor subtypes expressed in Xenopus oocytes (Watterson et al., 1996). R.L.P. was supported in part by NIH R01 NS3288 and a grant from R. J. Reynolds Tobacco Co.

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